Protein Alignment HRH2 and Octbeta1R

DIOPT Version :10

• Sequence 1: NP_001354640.1
• Gene: HRH2 / 3274
• HGNCID: 5183
• Length: 422
• Species: Homo sapiens
• Sequence 2: NP_651057.1
• Gene: Octbeta1R / 42652
• FlyBaseID: FBgn0038980
• Length: 508
• Species: Drosophila melanogaster
• Alignment Length: 356
• Identity: 125/356 - (35%)
• Similarity: 194/356 - (54%)
• Gaps: 52/356 - (14%)

Human    24 VLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGK 88
            ::..:||..:.||::|.::|..:|:||.:||.|:||||:.|:|:.|..:.|:|...:|.||.||.
  Fly   113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGS 177

Human    89 VFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLS 153
            |.|:::.|.||...||||::|..||:|||.|::.||.||:::|..||.|.|:::|:....||||.
  Fly   178 VMCDMWNSFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLP 242

Human   154 IHLGWNSRNETSK----GNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAK 214
            |..||.:..|..|    ..|.   |:.:||:.|.:|...::|::|.::|...||||::.| |:.:
  Fly   243 ICSGWYTTTENYKYLKSNPHI---CEFKVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQEA-DRQE 303

Human   215 RINHISSWKA-----------------------ATI----REHKATVTLAAVMGAFIICWFPYFT 252
            |:.:.|...|                       :||    ||.||..||..:|.||:|||.|:|.
  Fly   304 RLVYRSKVAALLLEKHLQISQIPKPRPSIQVEQSTISTMRRERKAARTLGIIMSAFLICWLPFFL 368

Human   253 AFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQ----------LFCCRL 307
            .::...|........:|..|:.|:||.|||||||:||..|||||..:::          .||.|.
  Fly   369 WYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAFKKTLKSLFPYAFYFCRRG 433

Human   308 ANRNSHK------TSLR-SNASQLSRTQSRE 331
            ..|:..:      .|.| :|.:|.:.:.|.|
  Fly   434 RGRDDDRDLEFGGPSRRGTNGAQRTGSGSAE 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HRH2	NP_001354640.1	7tmA_Histamine_H2R	19..299	CDD:320179	115/305 (38%)
		TM helix 1	20..46	CDD:320179	6/21 (29%)
		TM helix 2	53..80	CDD:320179	12/26 (46%)
		TM helix 3	91..121	CDD:320179	15/29 (52%)
		TM helix 4	133..153	CDD:320179	8/19 (42%)
		TM helix 5	179..209	CDD:320179	10/29 (34%)
		TM helix 6	227..257	CDD:320179	15/33 (45%)
		TM helix 7	267..292	CDD:320179	14/24 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	316..340		6/17 (35%)
Octbeta1R	NP_651057.1	7tmA_DmOct-betaAR-like	109..415	CDD:320194	115/305 (38%)
		TM helix 1	109..135	CDD:320194	6/21 (29%)
		TM helix 2	142..168	CDD:320194	12/25 (48%)
		TM helix 3	180..210	CDD:320194	15/29 (52%)
		TM helix 4	222..245	CDD:320194	10/22 (45%)
		TM helix 5	269..298	CDD:320194	10/28 (36%)
		TM helix 6	343..373	CDD:320194	14/29 (48%)
		TM helix 7	383..408	CDD:320194	14/24 (58%)