Protein Alignment HRH2 and TyrRII

DIOPT Version :10

• Sequence 1: NP_001354640.1
• Gene: HRH2 / 3274
• HGNCID: 5183
• Length: 422
• Species: Homo sapiens
• Sequence 2: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Alignment Length: 528
• Identity: 115/528 - (21%)
• Similarity: 175/528 - (33%)
• Gaps: 223/528 - (42%)

Human     8 SSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVL 72
            :|:.:.....|.....|..|:||:||.||.:|.|||...||||.:||||:::|||||.|:|..|:
  Fly    64 NSYLVSMAWPKSLAVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVM 128

Human    73 PFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAI 137
            |.|.:..::..|.||.:.|:|:.|||::||:.|||:|..||||||.||..||.|.......|:|:
  Fly   129 PPSVVLYITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLAL 193

Human   138 SLVL-IWVISITLSFLSIHLGWNSRNETSKGNHTTS--KCKVQVNEVYGLVDGLVTFYLPLLIMC 199
            .::| :|:.::::: ...:|||     ...|.|...  .|:...|:.|.:...:.:|::||.:|.
  Fly   194 LMILVVWITALSIT-CPPYLGW-----YEVGRHQAEFVDCRYNQNKGYVVFSAMGSFFIPLTVML 252

Human   200 ITYYRIFKVARDQAKRI-----------------------------------NHISSWK------ 223
            ..|.:|..|...:.:||                                   |..|.|:
  Fly   253 YVYVKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHD 317

Human   224 ----------------------------------------------------------------- 223
                                                                             
  Fly   318 PPPSAATNAAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSS 382

Human   224 ----------------------------------------------------------------- 223
                                                                             
  Fly   383 LIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEA 447

Human   224 ----------------------------------------AATIREHKATVTLAAVMGAFIICWF 248
                                                    :.|.|:.|...||..|||..|.||.
  Fly   448 KQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWL 512

Human   249 PYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFC---CRLANR 310
            |:|..::........|:.|.|.....|:|:.|.|:||.:||..|.||||.:.:|.|   |:....
  Fly   513 PFFVYYLLIPFLPRPAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAFWRLTCRPICKQKRP 577

Human   311 NSHKTSLR 318
            .:|....|
  Fly   578 PNHLAMFR 585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HRH2	NP_001354640.1	7tmA_Histamine_H2R	19..299	CDD:320179	108/493 (22%)
		TM helix 1	20..46	CDD:320179	12/25 (48%)
		TM helix 2	53..80	CDD:320179	14/26 (54%)
		TM helix 3	91..121	CDD:320179	18/29 (62%)
		TM helix 4	133..153	CDD:320179	4/20 (20%)
		TM helix 5	179..209	CDD:320179	8/29 (28%)
		TM helix 6	227..257	CDD:320179	12/29 (41%)
		TM helix 7	267..292	CDD:320179	10/24 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	316..340		1/3 (33%)
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	75/197 (38%)
		TM helix 1	78..101	CDD:410628	12/22 (55%)
		TM helix 2	110..132	CDD:410628	12/21 (57%)
		TM helix 3	148..170	CDD:410628	11/21 (52%)
		TM helix 4	194..210	CDD:410628	2/16 (13%)
		TM helix 5	233..256	CDD:410628	5/22 (23%)
		7tm_GPCRs	<491..563	CDD:475119	28/71 (39%)
		TM helix 6	497..519	CDD:320098	10/21 (48%)
		TM helix 7	531..556	CDD:320098	10/24 (42%)