Protein Alignment HRH2 and Octbeta2R

DIOPT Version :10

• Sequence 1: NP_001354640.1
• Gene: HRH2 / 3274
• HGNCID: 5183
• Length: 422
• Species: Homo sapiens
• Sequence 2: NP_001163596.2
• Gene: Octbeta2R / 41549
• FlyBaseID: FBgn0038063
• Length: 630
• Species: Drosophila melanogaster
• Alignment Length: 383
• Identity: 116/383 - (30%)
• Similarity: 191/383 - (49%)
• Gaps: 80/383 - (20%)

Human    24 VLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGK 88
            |:.::|:..:.||::|.::|...|:||.:||.|:||||:.|:::.::.:.|:...|::.:|:|..
  Fly   159 VMLLIIIAAICGNLLVIISVMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNFSVQVTGRWNFSP 223

Human    89 VFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLS 153
            ..|:::.||||...|||||:|..||:|||.|::.||:||:.:|...|.|.|:..|:....||||.
  Fly   224 FLCDLWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRVVGIMLLNTWISPALLSFLP 288

Human   154 IHLGWNSRNETSKGNHTT-----------SKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFK 207
            |.:||          :||           ::|...||:.|.::...::|::|..||..||..||:
  Fly   289 IFIGW----------YTTPQHQQFVIQNPTQCSFVVNKYYAVISSSISFWIPCTIMIFTYLAIFR 343

Human   208 VARDQAKR----------------------INHISSWKAATI-------------------REHK 231
            .|..|.|:                      ::...|.|..|:                   ||||
  Fly   344 EANRQEKQLMMRHGNAMLMHRPSMQPSGEALSGSGSSKTLTLHEVEQEHTPTKDKHLIKMKREHK 408

Human   232 ATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFR 296
            |..||..:||.||:||.|:|..:.......:..:.:::.:|:.|:||.||.|||::||..|||||
  Fly   409 AARTLGIIMGTFILCWLPFFLWYTLSMTCEECQVPDIVVSILFWIGYFNSTLNPLIYAYFNRDFR 473

Human   297 TGYQQLFCCRLAN--RNSH--------KTSLR--------SNASQLSRTQSREPRQQE 336
            ..::....|...|  ::.|        ::|||        .:.|.|:.|.....||.:
  Fly   474 EAFRNTLLCLFCNWWKDRHLPLDIDIRRSSLRYDQRAKSVYSESYLNSTTPSHRRQSQ 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HRH2	NP_001354640.1	7tmA_Histamine_H2R	19..299	CDD:320179	105/326 (32%)
		TM helix 1	20..46	CDD:320179	6/21 (29%)
		TM helix 2	53..80	CDD:320179	9/26 (35%)
		TM helix 3	91..121	CDD:320179	17/29 (59%)
		TM helix 4	133..153	CDD:320179	7/19 (37%)
		TM helix 5	179..209	CDD:320179	10/29 (34%)
		TM helix 6	227..257	CDD:320179	15/48 (31%)
		TM helix 7	267..292	CDD:320179	11/24 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	316..340		8/29 (28%)
Octbeta2R	NP_001163596.2	7tmA_DmOct-betaAR-like	155..476	CDD:320194	105/326 (32%)
		TM helix 1	155..181	CDD:320194	6/21 (29%)
		TM helix 2	188..214	CDD:320194	9/25 (36%)
		TM helix 3	226..256	CDD:320194	17/29 (59%)
		TM helix 4	268..291	CDD:320194	9/22 (41%)
		TM helix 5	315..344	CDD:320194	10/28 (36%)
		TM helix 6	404..434	CDD:320194	15/29 (52%)
		TM helix 7	444..469	CDD:320194	11/24 (46%)