| Sequence 1: | NP_001354640.1 | Gene: | HRH2 / 3274 | HGNCID: | 5183 | Length: | 422 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001262373.1 | Gene: | 5-HT2B / 41017 | FlyBaseID: | FBgn0261929 | Length: | 947 | Species: | Drosophila melanogaster |
| Alignment Length: | 200 | Identity: | 75/200 - (37%) |
|---|---|---|---|
| Similarity: | 121/200 - (60%) | Gaps: | 5/200 - (2%) |
- Green bases have known domain annotations that are detailed below.
|
Human 27 VLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFC 91
Human 92 NIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHL 156
Human 157 GWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISS 221
Human 222 WKAAT 226 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| HRH2 | NP_001354640.1 | 7tmA_Histamine_H2R | 19..299 | CDD:320179 | 74/199 (37%) |
| TM helix 1 | 20..46 | CDD:320179 | 11/18 (61%) | ||
| TM helix 2 | 53..80 | CDD:320179 | 13/26 (50%) | ||
| TM helix 3 | 91..121 | CDD:320179 | 15/29 (52%) | ||
| TM helix 4 | 133..153 | CDD:320179 | 7/19 (37%) | ||
| TM helix 5 | 179..209 | CDD:320179 | 12/29 (41%) | ||
| TM helix 6 | 227..257 | CDD:320179 | 74/199 (37%) | ||
| TM helix 7 | 267..292 | CDD:320179 | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 316..340 | ||||
| 5-HT2B | NP_001262373.1 | 7tmA_5-HT2_insect-like | 74..>267 | CDD:320433 | 72/189 (38%) |
| TM helix 1 | 75..101 | CDD:320433 | 11/18 (61%) | ||
| TM helix 2 | 108..134 | CDD:320433 | 13/25 (52%) | ||
| TM helix 3 | 146..176 | CDD:320433 | 15/29 (52%) | ||
| TM helix 4 | 188..211 | CDD:320433 | 8/23 (35%) | ||
| TM helix 5 | 229..258 | CDD:320433 | 12/28 (43%) | ||
| 7tm_GPCRs | <799..893 | CDD:475119 | |||
| TM helix 6 | 818..840 | CDD:410628 | |||
| TM helix 7 | 854..879 | CDD:410628 | |||
| Blue background indicates that the domain is not in the aligned region. | |||||