DRSC/TRiP Functional Genomics Resources

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Protein Alignment HRH2 and 5-HT2A

DIOPT Version :10

Sequence 1:NP_001354640.1 Gene:HRH2 / 3274 HGNCID:5183 Length:422 Species:Homo sapiens
Sequence 2:NP_730859.1 Gene:5-HT2A / 40575 FlyBaseID:FBgn0087012 Length:930 Species:Drosophila melanogaster


Alignment Length:485 Identity:128/485 - (26%)
Similarity:186/485 - (38%) Gaps:137/485 - (28%)


- Green bases have known domain annotations that are detailed below.


Human     3 PNGTASSFCLDSTACKITITVVLAV--------------LILITV-------AGNVVVCLAVGLN 46
            ||.||.:  ..|||....:....||              |.|..|       .||::|||||.|:
  Fly   251 PNLTALN--TTSTASTADMATEFAVTKSFLDYSPHGYDFLFLFVVFFIFAGGLGNILVCLAVALD 313

Human    47 RRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFM 111
            |:|:|:||.|:.||||.|||:.|.|:|..||......|..|..:||||.:.||:.|::|||::..
  Fly   314 RKLQNVTNYFLFSLAIADLLVSLFVMPMGAIPAFLGYWPLGFTWCNIYVTCDVLACSSSILHMCF 378

Human   112 ISLDRYCAVMDPL----RYPVLVTPVRVAISLVLIWVISITLSFLSIHLGW-NSRNETSKGNHTT 171
            |||.||..:.:||    |....:|.:::||    :||:::.:|.....||. |.:|...:.|   
  Fly   379 ISLGRYMGIRNPLGSRHRSTKRLTGIKIAI----VWVMAMMVSSSITVLGLVNEKNIMPEPN--- 436

Human   172 SKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTL 236
             .|.:. |..:.:...||.||:|:|:|..||.....:.|.           ||....||..:...
  Fly   437 -ICVIN-NRAFFVFGSLVAFYIPMLMMVTTYALTIPLLRK-----------KARFAAEHPESELF 488

Human   237 AAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQ 301
            ..:.|.|.              ||...: .:.|:....:.|..|..|:          ...|   
  Fly   489 RRLGGRFT--------------LRPQHS-QQQLQMFSSFSGSNNKFLS----------MGDG--- 525

Human   302 LFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQ---------------VWSGTEVT 351
                   |||.:...........||....||   .|:||..|               |.:||...
  Fly   526 -------NRNFNTEGEMEEGGAPSRRSGVEP---AERPLMQQRTASSRSMGTVSFRNVVNGTSGA 580

Human   352 APQGA--------------------TDRKPALSCTTCSSNLLSCCKSLWGLRFLQRHMGGPS--- 393
            |..|.                    :...||.||.:.|::..|   |.|     ::|.|.|:   
  Fly   581 AGSGRRTTGTAHSSFRFSGAGIFRHSSSSPASSCHSTSTSRSS---SFW-----RKHGGYPNLMD 637

Human   394 -----EELSGEPLSEEPQKRPPQKAVRTLP 418
                 ..||..|.|..|.:|...:...:.|
  Fly   638 RLAIHLRLSLVPPSSHPNRRASVRVTISQP 667

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HRH2NP_001354640.1 7tmA_Histamine_H2R 19..299 CDD:320179 86/305 (28%)
TM helix 1 20..46 CDD:320179 12/46 (26%)
TM helix 2 53..80 CDD:320179 15/26 (58%)
TM helix 3 91..121 CDD:320179 15/29 (52%)
TM helix 4 133..153 CDD:320179 5/19 (26%)
TM helix 5 179..209 CDD:320179 10/29 (34%)
TM helix 6 227..257 CDD:320179 4/29 (14%)
TM helix 7 267..292 CDD:320179 4/24 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 316..340 5/23 (22%)
5-HT2ANP_730859.1 7tm_GPCRs 298..>473 CDD:475119 68/183 (37%)
TM helix 2 321..343 CDD:410628 12/21 (57%)
TM helix 3 359..381 CDD:410628 10/21 (48%)
TM helix 4 404..420 CDD:410628 5/19 (26%)
TM helix 5 443..466 CDD:410628 8/22 (36%)
7tm_GPCRs <779..858 CDD:475119
TM helix 6 792..814 CDD:410628
TM helix 7 826..851 CDD:410628
Blue background indicates that the domain is not in the aligned region.

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