Protein Alignment HRH2 and 5-HT1B

DIOPT Version :10

• Sequence 1: NP_001354640.1
• Gene: HRH2 / 3274
• HGNCID: 5183
• Length: 422
• Species: Homo sapiens
• Sequence 2: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Alignment Length: 568
• Identity: 121/568 - (21%)
• Similarity: 189/568 - (33%)
• Gaps: 252/568 - (44%)

Human     4 NGTASSFCL-----DSTACK-------ITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCF 56
            ||.:::|.|     :..|.:       |.:.|||.::||:|:.|||.|..|:.|.|.|:|:.|..
  Fly    64 NGNSNTFDLVDDEQERAAVEFWLLVKMIAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYL 128

Human    57 IVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVM 121
            :.|||:.||.:..||:|..|:|::|..|..|...|:|:||.||:.||||||:|..|:.|||..|.
  Fly   129 VASLAVADLFVACLVMPLGAVYEISNGWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVT 193

Human   122 DPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVD 186
            : :.|..|.||.||.:.:..:|..::.:| |:...||...:...:...  ..|.|..:..|.:..
  Fly   194 N-IDYNNLRTPRRVFLMIFCVWFAALIVS-LAPQFGWKDPDYMKRIEE--QHCMVSQDVGYQIFA 254

Human   187 GLVTFYLPLLIMCITYYRIFKVARDQAKR------------------------------------ 215
            ...|||:|||::...|::|:.:||.:.:|
  Fly   255 TCCTFYVPLLVILFLYWKIYIIARKRIQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRL 319

Human   216 ----------------------------------------------------------------- 215
                                                                             
  Fly   320 EAGERTPVDGDGTGGQLQRRTRKRMRICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITRE 384

Human   216 --------------------------------------------------------INHIS---- 220
                                                                    :|.|:
  Fly   385 ETEFSTSNYDNKSHAGTELTTVSSDADDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQ 449

Human   221 ---------------SWKA---------------------------------------ATI---- 227
                           |.||                                       |:|
  Fly   450 SIAMGGVGCLTTTTPSEKALSGAGTVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPH 514

Human   228 -------------REHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYA 279
                         ||.||..|||.:.|||:|||.|:|...:...|..:..|:..:.::.|||||.
  Fly   515 QKLAKRRQLLEAKRERKAAQTLAIITGAFVICWLPFFVMALTMSLCKECEIHTAVASLFLWLGYF 579

Human   280 NSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKT----SLRSNASQ 323
            ||.|||::|...|.:||..::::...|.|...:...    .|:.|..|
  Fly   580 NSTLNPVIYTIFNPEFRRAFKRILFGRKAAARARSAKIXFQLKDNEDQ 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HRH2	NP_001354640.1	7tmA_Histamine_H2R	19..299	CDD:320179	111/511 (22%)
		TM helix 1	20..46	CDD:320179	11/25 (44%)
		TM helix 2	53..80	CDD:320179	11/26 (42%)
		TM helix 3	91..121	CDD:320179	17/29 (59%)
		TM helix 4	133..153	CDD:320179	4/19 (21%)
		TM helix 5	179..209	CDD:320179	9/29 (31%)
		TM helix 6	227..257	CDD:320179	16/46 (35%)
		TM helix 7	267..292	CDD:320179	11/24 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	316..340		3/8 (38%)
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	11/25 (44%)
		TM helix 2	125..151	CDD:320454	10/25 (40%)
		TM helix 3	163..193	CDD:320454	17/29 (59%)
		TM helix 4	204..226	CDD:320454	5/22 (23%)
		TM helix 5	247..276	CDD:320454	9/28 (32%)
		7tm_GPCRs	<525..599	CDD:475119	31/73 (42%)
		TM helix 6	533..555	CDD:410628	11/21 (52%)
		TM helix 7	567..592	CDD:410628	11/24 (46%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	73/199 (37%)