Protein Alignment HRH2 and mAChR-C

DIOPT Version :10

• Sequence 1: NP_001354640.1
• Gene: HRH2 / 3274
• HGNCID: 5183
• Length: 422
• Species: Homo sapiens
• Sequence 2: NP_572358.1
• Gene: mAChR-C / 31626
• FlyBaseID: FBgn0029909
• Length: 371
• Species: Drosophila melanogaster
• Alignment Length: 327
• Identity: 93/327 - (28%)
• Similarity: 158/327 - (48%)
• Gaps: 36/327 - (11%)

Human    19 ITITVVLAVLILITVAGNVVVCLAVGLNRRLRN-LTNCFIVSLAITDLLLGLLVLPFSAIYQLSC 82
            :.|...|.||||   .||::..:||...|.||: ::|.||:|||::|..:| |.||:..::.:..
  Fly    54 LAINAFLFVLIL---GGNILTIVAVRTCRHLRSVISNLFILSLAVSDFCVG-LALPYHLVFYMGS 114

Human    83 KWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLI-WVIS 146
            .....:..|.:...|.:..|..|:|.|..|::|||.||:..|.|...:|. |||.|:::. |.:.
  Fly   115 DIGAMRGPCLLRFFLLICACCVSMLTLISIAVDRYIAVVYALHYRRYMTR-RVAYSIIIFNWCLG 178

Human   147 ITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVT--FYLPLLIMCITYYRIFKVA 209
            ..::.|.:.  ||...:       ...|:.......|.:.|::|  |.:..:.|.:.|:||.:.|
  Fly   179 ALVALLPVF--WNRWPD-------AQACEFDEVLAPGYIAGVITPGFVIIWICMFLVYWRIMREA 234

Human   210 RDQAKRINH---ISSWKAATIR------EHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAI 265
            ..||.|:..   .::.:|.|:|      :.|:...:..:||.|.:||.|||...:.: |......
  Fly   235 SKQALRLRQSVVYNTDEATTMRNLLLHPDWKSVQIVVFIMGCFTLCWLPYFCVAIAQ-LFSICQS 298

Human   266 NEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANR--------NSHKTSLRSNAS 322
            :.::......|..||||||||:|:..|..||..:.|..|||.|.:        :.|:....|::.
  Fly   299 SSMIYKTTFSLAIANSALNPIIYSWKNSGFRRAFVQTLCCRTARQCEDQLPADSKHRMEATSSSQ 363

Human   323 QL 324
            ::
  Fly   364 EI 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HRH2	NP_001354640.1	7tmA_Histamine_H2R	19..299	CDD:320179	86/292 (29%)
		TM helix 1	20..46	CDD:320179	10/25 (40%)
		TM helix 2	53..80	CDD:320179	11/26 (42%)
		TM helix 3	91..121	CDD:320179	11/29 (38%)
		TM helix 4	133..153	CDD:320179	5/20 (25%)
		TM helix 5	179..209	CDD:320179	8/31 (26%)
		TM helix 6	227..257	CDD:320179	10/35 (29%)
		TM helix 7	267..292	CDD:320179	10/24 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	316..340		1/9 (11%)
mAChR-C	NP_572358.1	7tm_classA_rhodopsin-like	53..325	CDD:410626	83/285 (29%)
		TM helix 1	53..78	CDD:410626	10/26 (38%)
		TM helix 2	86..111	CDD:410626	11/25 (44%)
		TM helix 3	123..153	CDD:410626	11/29 (38%)
		TM helix 4	166..185	CDD:410626	4/18 (22%)
		TM helix 5	204..229	CDD:410626	6/24 (25%)
		TM helix 6	261..291	CDD:410626	9/29 (31%)
		TM helix 7	300..325	CDD:410626	10/24 (42%)