DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ankle2 and Ankle2

DIOPT Version :9

Sequence 1:	NP_573221.2	Gene:	Ankle2 / 32732	FlyBaseID:	FBgn0028343	Length:	1174	Species:	Drosophila melanogaster
Sequence 2:	NP_001240743.1	Gene:	Ankle2 / 71782	MGIID:	1261856	Length:	964	Species:	Mus musculus

Alignment Length:	1075	Identity:	234/1075 - (21%)
Similarity:	367/1075 - (34%)	Gaps:	414/1075 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 NPASGSASVASGSPSGSAASVQTGNADDGSAATK-----------YEDPDYPPDSPLWLIFTEKS 90
            ||....|..:|..|...:||.:..|...|..|.|           |||.  |.......::.:|.
Mouse   168 NPPEEEAVASSVHPVPFSASTRNDNHKAGVTAPKEPLVYYGVCPVYEDG--PVRHERIHVYEDKK 230

  Fly    91 KALDILRHYKEARLREFPNLEQAESYVQFGFESIEALKRFCKAKPE-SKPIPIISGSGYKSSPTS 154
            :||...:..|.:|.:.|...|.||.:.          :..|...|. :|..|::       ||..
Mouse   231 EALQAAKLIKGSRFKAFRTREDAEKFA----------RGICDYLPSPNKTTPLL-------SPVK 278

  Fly   155 TDNSCSSSPTGNGSGFIIPLGSNSSM--SNLLLSDSPTSSPSSSSNVIANGRQQQMQQQQQQQPQ 217
            .                :|||.:..:  ..|.|::|.|.:...:::
Mouse   279 A----------------VPLGGSDGLKADGLCLAESETVNKERANS------------------- 308

  Fly   218 QPDVSGEGPPFRAPTKQEL-VEFRKQIEGGHIDRVKRIIWENPRFLISSGDTPTSLKEGCRYNAM 281
                      ::.|..|:| .:.||.:|.|.......:||.|||:||.|||.||.::||||||.|
Mouse   309 ----------YKNPRTQDLTAKLRKAVENGEEHTFSDLIWSNPRYLIGSGDNPTIVQEGCRYNVM 363

  Fly   282 HICAQVNKARIAQLLLKTISDREFTQLYVGKKGSGKMCAALNISLLDYYLNMPDKGRGETPLHFA 346
            |:.|:.|:|.:.||.|:|:.:.||.:|.........:...: :.::|.|||.|||...:||||||
Mouse   364 HVAAKENQASMCQLTLETLENPEFMRLMYPDDNMDMLQKRI-LYVVDLYLNTPDKVGFDTPLHFA 427

  Fly   347 AKNGHVAMVEVLVSYP-ECKSLRNHEGKEPKEIICLRNANATHVTIKKLELLLYDPHFVPVLRSQ 410
            .|.|:|.:|.||.|:| ..|:.:|..||.|:|:||.|:.|.:....:::...|...::||:||::
Mouse   428 CKFGNVDVVNVLSSHPLIVKNRKNKYGKTPEEVICERSQNKSPALKERIREYLMGHYYVPLLRAE 492

  Fly   411 SNTLPPKVGQPF----------------SPKDPPNLQHKADDYEGLSVDLAISALAGPMSREKAM 459
            ..:  |.:|:.:                ||:||.               :.:.|..||:|..||.
Mouse   493 DTS--PVIGELWSSDQKAEASNTAHCRSSPRDPV---------------MTLRAFVGPLSPSKAE 540

  Fly   460 NFYRRWKTPPRVSNNVMSPLAGSPFSSPVKVTPSKSIFDRSAGNSSPVHSGRRVLFSPLAEATSS 524
            :|.:.||||||                            :.||.   .||
Mouse   541 DFRKLWKTPPR----------------------------KKAGF---FHS--------------- 559

  Fly   525 PKPTKNVPNGTNECEHNNNNVKPVYPLEFPATPIRKMKPDLFMAYRNNNSFDSPSLADDSQILDM 589

Mouse   560 ----------------------------------------------------------------- 559

  Fly   590 SLSRSLNASLNDSFRERHIKNTDIEKGLEVVGRQLARQEQLEWREYWDFLDSFLDIGTTEGLARL 654
                              |:.:|.|:|:|.|||:||.:....|.|||:||..|:|:.:.|||.||
Mouse   560 ------------------IRKSDPERGIERVGRELAHELGYPWVEYWEFLGCFVDLSSQEGLQRL 606

  Fly   655 EAYFLEKTEQQADKSETVWNFAHLHQYFDSMAGEQQQQLRKDKNEAAGATSPSAGVMTPYTCVEK 719
            |.|.::|                      .::.:.||::|:::.                 |::.
Mouse   607 EEYLIQK----------------------ELSKKAQQEIRENEG-----------------CLQD 632

  Fly   720 SLQVFAKRITKTLINKIGNMVSI-------NDTLLCELKRLKSLIVSFKDDARFISVDFSKVHSR 777
            ....|...      .|..|.:|:       :|:.|.|:|..::.:.|
Mouse   633 RTSDFGSG------KKYSNSISVGAFLDGDDDSSLEEIKNQQNTVPS------------------ 673

  Fly   778 IAHLVASYVTHSQEVSVAMRLQLLQML-------------------RSLRQLLADERGREQHLGC 823
                .:...|...:.|.:..|.|.|.:                   ..|....||.||.|...|
Mouse   674 ----QSQPTTDKFQTSKSGSLPLGQKVDPGETSVGTYPDKGRNGFCHPLNHRTADGRGLEATNG- 733

  Fly   824 VCASLLLMLEQAPTSAVHLPDTLKTEELCCAAWETEQCCACLWDANLSRKTSRRKRTKSLRAAAV 888
                         ..|:..|.::.|:||                             ..|...::
Mouse   734 -------------EEALPPPVSVLTQEL-----------------------------NKLNLQSL 756

  Fly   889 VQSQGQLQDTSGSTGSSALHASLGVGSTSLGAS-RVVASASKDAWRRQQSDDEDYDSDEQVIFFD 952
            ..|..:..|.:|......|.:..|...:.|.|| ..:||..|...|
Mouse   757 GDSLHETPDKNGKLEDEVLPSRKGAADSDLLASPPAIASLGKKQVR------------------- 802

  Fly   953 CTNVTLPYGSSSEDEENFRTPPQSLSPGISMDLEP---------RYELFIFGNEPTKRDLDVLNA 1008
             ||..:     ||........|:|...|:...|||         ...||:.|.||:|.|.|||.|
Mouse   803 -TNTEV-----SEAMAEMSLGPKSPQLGVQAGLEPILSSATVDSTKRLFLSGEEPSKLDRDVLAA 861

  Fly  1009 LSNVDIDKETLPHVYAWKTAMESYSCAEMNLFPSP 1043
            |...:||....|.::.||:.:..||.::...:|||
Mouse   862 LECANIDPGLYPAIHRWKSTVMCYSPSDRQSWPSP 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ankle2	NP_573221.2	ANK repeat	280..335	CDD:293786	16/54 (30%)
		Ank_2	281..361	CDD:403870	31/79 (39%)
		ANK repeat	337..369	CDD:293786	15/32 (47%)
Ankle2	NP_001240743.1	LEM_ANKL2	73..115	CDD:240591
		Cauli_VI	<225..256	CDD:279957	6/30 (20%)
		ANK	342..457	CDD:238125	37/115 (32%)
		ANK repeat	356..384	CDD:293786	7/28 (25%)
		ANK repeat	418..451	CDD:293786	9/32 (28%)
		ANK	419..448		9/28 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	666..726		0/59 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	920..949		9/47 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839822
Domainoid	1	1.000	167	1.000	Domainoid score	I3847
eggNOG	1	0.900	-	-		E1_2CMEJ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	270	1.000	Inparanoid score	I3002
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007072
OrthoInspector	1	1.000	-	-		oto94849
orthoMCL	1	0.900	-	-		OOG6_107599
Panther	1	1.100	-	-	LDO	PTHR12349
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2398
SonicParanoid	1	1.000	-	-		X5160
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.780