DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ankle2 and ankle2

DIOPT Version :9

Sequence 1:NP_573221.2 Gene:Ankle2 / 32732 FlyBaseID:FBgn0028343 Length:1174 Species:Drosophila melanogaster
Sequence 2:NP_001119867.1 Gene:ankle2 / 559297 ZFINID:ZDB-GENE-030131-6090 Length:961 Species:Danio rerio


Alignment Length:1244 Identity:283/1244 - (22%)
Similarity:443/1244 - (35%) Gaps:455/1244 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 NIKPSNPASGSASVASGSP-----------------SGSAASVQTGNADDGSAATKYEDPDYPPD 79
            ::.||:.||.:....:|..                 ||:..:....|....| .|....|.:...
Zfish    68 SVVPSSAASATPDAITGEDGDFGYGMGLNPPEEEALSGTVCACNVENTQTPS-KTAQVSPTFYGV 131

  Fly    80 SPLW----------LIFTEKSKALDILRHYKEARLREFPNLEQAESYVQFGFESIEALKRFCKAK 134
            .|||          .::|:|.:||..::..|.||.:.|.|.|.||.:.          |..|...
Zfish   132 CPLWEDVLARNERAHVYTDKKEALQAVKMMKGARFKAFSNREDAEKFA----------KGICDYY 186

  Fly   135 PE-SKPIPIISGSGYKSSPTSTDNSCSSSPTGNGSGFIIPLGSNSSMSNLLLSDSPTSSPSSSSN 198
            |. ||..|.:                  ||...|..|      :....:::.:|:.....::|  
Zfish   187 PSPSKSTPCV------------------SPVKPGLVF------SKDHPSMIEADTINREKANS-- 225

  Fly   199 VIANGRQQQMQQQQQQQPQQPDVSGEGPPFRAPTKQEL-VEFRKQIEGGHIDRVKRIIWENPRFL 262
                                         |::|..|:| .:.||.:|.|.......::|.|||:|
Zfish   226 -----------------------------FKSPRTQDLTAKLRKAVEKGDELGFTELVWSNPRYL 261

  Fly   263 ISSGDTPTSLKEGCRYNAMHICAQVNKARIAQLLLKTISDREFTQLYVGKKGSGKMCAALNISLL 327
            |.|||.||.::||||||.||:.|:.|:..|.|:||.|:.:.||.:|.........:...:.. ::
Zfish   262 IGSGDNPTVVQEGCRYNVMHVAAKENQPGIVQILLDTLENPEFMRLMYPDDLESMLQKRIRY-IV 325

  Fly   328 DYYLNMPDKGRGETPLHFAAKNGHVAMVEVLVSYPEC-KSLRNHEGKEPKEIIC--LRNANATHV 389
            |.|||.|||...|||||||.|.|...:|.:|.|:|:. |:.:|...::|.|:||  ::.......
Zfish   326 DLYLNTPDKAGFETPLHFACKFGCPEVVNILCSHPDIDKNCKNKYNQKPCEVICERMKEKGKVQE 390

  Fly   390 TIKKLELLLYDPHFVPVLRSQSNTLPPKVGQPF--------------SPKDPPNLQHKADDYEGL 440
            ..:|:...|.:..::|:||:..|:....:|.|:              |||||.            
Zfish   391 VKQKINEYLEERLYIPLLRATDNSSQAVIGAPWSPEPMESLSPWLPRSPKDPV------------ 443

  Fly   441 SVDLAISALAGPMSREKAMNFYRRWKTPPRVSNNVMSPLAGSPFSSPVKVTPSKSIFDRSAGNSS 505
               :|:.|.|||:|..||..|.|.||||||                                   
Zfish   444 ---MAVRAFAGPLSPSKADEFRRAWKTPPR----------------------------------- 470

  Fly   506 PVHSGRRVLFSPLAEATSSPKPTKNVPNGTNECEHNNNNVKPVYPLEFPATPIRKMKPDLFMAYR 570
                                          ...:|.:|.:|                        
Zfish   471 ------------------------------ERADHFHNILK------------------------ 481

  Fly   571 NNNSFDSPSLADDSQILDMSLSRSLNASLNDSFRERHIKNTDIEKGLEVVGRQLARQEQLEWREY 635
                                                    :|.::|.|.|||.||.:....|.||
Zfish   482 ----------------------------------------SDPDRGAERVGRDLAHELGHPWAEY 506

  Fly   636 WDFLDSFLDIGTTEGLARLEAY-----FLEKTEQQADKSETVWNFAHLHQYFDSMAGEQQQQLRK 695
            |||||||:|:.:||||..||.|     |.|:..::|.::||...|                    
Zfish   507 WDFLDSFVDLQSTEGLKMLEEYLSKKDFRERAHEEAGENETSNRF-------------------- 551

  Fly   696 DKNEAAGATSPSAGVMTPYTCVEKSLQVFAKRITKTLINKIGNMVSINDTLLCELKRLKSLIVSF 760
                    .:||.|          .|:.|...|:      :|..:...|.:  .|:.:|:     
Zfish   552 --------KTPSPG----------KLKKFCNSIS------VGAFLDEGDDI--SLEEIKN----- 585

  Fly   761 KDDARFISVDFSKVHSRIA----------HLVASYVTHSQEVSVAMRLQLLQMLRSLRQLLADER 815
            :.:|...|:  |.|.|:..          |::.  |:||.::..|...|  .:|.|.:.:::..:
Zfish   586 RQNAALTSI--SSVCSKDGLQGAVGGLEFHILP--VSHSADLIEAAAEQ--DLLLSEKSMISSSK 644

  Fly   816 GR--EQHLG-----------CVCAS----LL-----LMLEQAPTSAVHLPD-TLKTEELCCAAWE 857
            ..  ||..|           .:|.|    :|     ||.|....|.:..|| |.:.........:
Zfish   645 NGLCEQGSGDRTPNGDKVSPRICGSSNSCMLSPISNLMAEFERMSLLDEPDRTNRERRRSGGKRQ 709

  Fly   858 TEQCCACLWDANLSRKTS---RRKRTKSLRAAAVVQSQGQLQDTSGSTGSSALHASLGVGSTSL- 918
            |.:..:.|...:||.:..   .:.||.:||||   ::.|..:.......|||......:.|..| 
Zfish   710 TTELTSGLGRLSLSSEDDSVFEKDRTSALRAA---ENDGTERRNEVDVRSSASSDEYFLASERLE 771

  Fly   919 ----------GASRVVASASKDAWRRQQSDDEDYDSDEQVIFFDCTNVTLPYGSSS-----EDEE 968
                      |..|::.:.|| :|   .....|..|.               ||||     :..:
Zfish   772 PINQQTIDTSGCERMICARSK-SW---DHGGRDLSSS---------------GSSSSYRSLDSSQ 817

  Fly   969 NF--RTPPQSLSPGISMDLEPRYELFIFGNEPTKRDLDVLNALSNVDIDKETLPHVYAWKTAMES 1031
            :|  ||||: ::.|          |||.|:.|||.|.:||:||...|.|....|.::.||:.:::
Zfish   818 DFILRTPPR-VTKG----------LFIEGDSPTKLDREVLSALGVSDFDPLKFPSIHKWKSTIQT 871

  Fly  1032 YSCAEMNLFPSPRNVKVQKPEPWYSGTSSSHNSQPLLHPKRLLATPKLNAVVSGRRGSGPLTAPV 1096
            ||.:||              :.|.  |.:.|.|    |.:.|.|||  .:.|||      |.:||
Zfish   872 YSQSEM--------------QSWL--TPAVHKS----HLRALSATP--GSPVSG------LMSPV 908

  Fly  1097 TPRLARTPSAASIQVASETNGESVGTAVTPASPILSFAALTAATQSFQTPLNKVRGLFSQYRDQR 1161
            : |.:......|....|........:..:||.|..|             |::.::.:       |
Zfish   909 S-RFSPARHMGSPDNCSPGRYSPAHSTYSPAHPNYS-------------PVSYIQRI-------R 952

  Fly  1162 SYNEGDTPL 1170
            ..:.||||:
Zfish   953 LKHFGDTPI 961

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ankle2NP_573221.2 ANK repeat 280..335 CDD:293786 16/54 (30%)
Ank_2 281..361 CDD:403870 30/79 (38%)
ANK repeat 337..369 CDD:293786 14/32 (44%)
ankle2NP_001119867.1 LEM_ANKL2 7..49 CDD:240591
Cauli_VI <147..178 CDD:279957 12/30 (40%)
ANK 238..374 CDD:238125 55/136 (40%)
Ank_2 238..368 CDD:289560 54/130 (42%)
ANK repeat 280..333 CDD:293786 16/53 (30%)
ANK repeat 335..368 CDD:293786 14/32 (44%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170583910
Domainoid 1 1.000 113 1.000 Domainoid score I6110
eggNOG 1 0.900 - - E1_2CMEJ
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 222 1.000 Inparanoid score I3514
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D259185at33208
OrthoFinder 1 1.000 - - FOG0007072
OrthoInspector 1 1.000 - - oto39166
orthoMCL 1 0.900 - - OOG6_107599
Panther 1 1.100 - - LDO PTHR12349
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2398
SonicParanoid 1 1.000 - - X5160
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
1413.790

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