DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ankle2 and Ankle2

DIOPT Version :9

Sequence 1:	NP_573221.2	Gene:	Ankle2 / 32732	FlyBaseID:	FBgn0028343	Length:	1174	Species:	Drosophila melanogaster
Sequence 2:	XP_008767565.3	Gene:	Ankle2 / 360829	RGDID:	1310191	Length:	1097	Species:	Rattus norvegicus

Alignment Length:	1072	Identity:	235/1072 - (21%)
Similarity:	375/1072 - (34%)	Gaps:	410/1072 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 NPASGSASVASGSPSGSAASVQTGNADDGSAATK-----------YEDPDYPPDSPLWL------ 84
            ||....|..:|..|...:||.:..|...|....|           |||         .|
  Rat   303 NPPEEEAVTSSVHPIPFSASTRNDNHKAGVTTAKEPLLYYGVCPVYED---------GLVRHERI 358

  Fly    85 -IFTEKSKALDILRHYKEARLREFPNLEQAESYVQFGFESIEALKRFCKAKPE-SKPIPIISGSG 147
             ::.:|.:||..::..|.:|.:.||..|.||.:.          :..|...|. ||.:.::
  Rat   359 HVYEDKKEALQAVKLIKGSRFKAFPTREDAEKFA----------RGICDYLPSPSKNMSLL---- 409

  Fly   148 YKSSPTSTDNSCSSSPTGNGSGFIIPLGSNSSMSNLLLSDSPTSSPSSSSNVIANGRQQQMQQQQ 212
               ||......||:....:|               |.|::|.|.:...:::
  Rat   410 ---SPVKAMPLCSNDGPKDG---------------LCLAESETVNKERANS-------------- 442

  Fly   213 QQQPQQPDVSGEGPPFRAPTKQEL-VEFRKQIEGGHIDRVKRIIWENPRFLISSGDTPTSLKEGC 276
                           ::.|..|:| .:.||.:|.|.......:||.|||:||.|||.||.::|||
  Rat   443 ---------------YKNPRTQDLTAKLRKAVERGEEHTFSDLIWSNPRYLIGSGDNPTIVQEGC 492

  Fly   277 RYNAMHICAQVNKARIAQLLLKTISDREFTQLYVGKKGSGKMCAALNISLLDYYLNMPDKGRGET 341
            |||.||:.|:.|:|.:.||.|:|:.:.||.:|.........:...: :.::|.|||.|||...:|
  Rat   493 RYNVMHVAAKENQASVCQLTLETLENPEFMRLMYPDDNMDMLQKRI-LYIVDLYLNTPDKVGFDT 556

  Fly   342 PLHFAAKNGHVAMVEVLVSYP-ECKSLRNHEGKEPKEIICLRNANATHVTIKKLELLLYDPHFVP 405
            |||||.|.|:|.:|.||.|:| ..|:.||..||.|:::||.|:.|.:....:::...|...::||
  Rat   557 PLHFACKFGNVDVVNVLSSHPLIVKNPRNKYGKTPEDVICERSKNKSVELRERIREYLMGHYYVP 621

  Fly   406 VLRSQSNTLPPKVGQPF----------------SPKDPPNLQHKADDYEGLSVDLAISALAGPMS 454
            :||::..:  |.:|:.:                ||:||.               :.:.|..||:|
  Rat   622 LLRAEDTS--PVIGELWSSDQKAEASSADHCRSSPRDPV---------------MTLRAFVGPLS 669

  Fly   455 REKAMNFYRRWKTPPRVSNNVMSPLAGSPFSSPVKVTPSKSIFDRSAGNSSPVHSGRRVLFSPLA 519
            ..||.:|.:.||||||                            :.||           ||
  Rat   670 PSKAEDFRKLWKTPPR----------------------------KKAG-----------LF---- 691

  Fly   520 EATSSPKPTKNVPNGTNECEHNNNNVKPVYPLEFPATPIRKMKPDLFMAYRNNNSFDSPSLADDS 584
                                |:
  Rat   692 --------------------HS------------------------------------------- 693

  Fly   585 QILDMSLSRSLNASLNDSFRERHIKNTDIEKGLEVVGRQLARQEQLEWREYWDFLDSFLDIGTTE 649
                                   |:.:|.|:|:|.|||:||.:....|.|||:||..|:|:.:.|
  Rat   694 -----------------------IRKSDPERGIERVGRELAHELGYPWVEYWEFLGCFVDLSSQE 735

  Fly   650 GLARLEAYFLEKT----------EQQADKSETVWNFAHLHQYFDSMA-------GE--QQQQLRK 695
            ||.|||.|.::|.          |::....:...:|....:|.:|::       |:  ..::::.
  Rat   736 GLQRLEEYLIQKELNQKAQHEIGEEEGCLQDRTSDFGSGKKYSNSISVGAFLDGGDDISLEEVKN 800

  Fly   696 DKNEAAGATSPSAGVMTPYTCVEKSLQVFAKRITKTLINKIGNMVSINDTLLCELKRLKSLIVSF 760
            .:|.....:.||                         ::|..|..|.:.:|..:....::.:..:
  Rat   801 QQNTVPSQSQPS-------------------------VDKFQNSKSGSPSLGQKADPGEAAVGFY 840

  Fly   761 KDDAR--FISVDFSKVHSRIAHLVASYVTHSQE-----VSVAMRLQLLQMLRSLR-QLLADERGR 817
            .|::|  |.    ..::||.|....:..|:.:|     ||:     |.|....|. |.|.|.
  Rat   841 PDNSRNGFC----YPLNSRTADGRETEATNGEEALPPPVSI-----LTQEFDKLNLQSLGDN--- 893

  Fly   818 EQHLGCVCASLLLMLEQAPTSAVHLPDTLKTEELCCAAWETEQCCACLWDANLSRKTSRRKRTKS 882
                          |.:.|.....|.|.:    |..:....|...|.  .|.::|..:::.||.|
  Rat   894 --------------LFETPNKNRELEDKI----LASSKGVVESGLAS--PAAIARLENKQVRTNS 938

  Fly   883 LRAAAVVQSQGQLQDTSGSTGSSALHASLGVGSTSLGASRVVASASKDAWRRQQSDDEDYDSDEQ 947
            ..:.|:.:                  .|||..|..||..
  Rat   939 EVSEAMAE------------------MSLGPNSPQLGVQ-------------------------- 959

  Fly   948 VIFFDCTNVTLPYGSSSEDEENFRTPPQSLSPGI-SMDLEPRYELFIFGNEPTKRDLDVLNALSN 1011
                                       ..|.||. |...:|...||:.|.||:|.|.|||.||..
  Rat   960 ---------------------------AGLEPGFSSATADPTKRLFLSGEEPSKLDRDVLAALEC 997

  Fly  1012 VDIDKETLPHVYAWKTAMESYSCAEMNLFPSP 1043
            ..||....|.|:.||:.:..||.::...:|||
  Rat   998 AIIDPGLYPAVHRWKSTVMGYSPSDRQSWPSP 1029

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ankle2	NP_573221.2	ANK repeat	280..335	CDD:293786	16/54 (30%)
		Ank_2	281..361	CDD:403870	31/79 (39%)
		ANK repeat	337..369	CDD:293786	15/32 (47%)
Ankle2	XP_008767565.3	COG5236	<171..318	CDD:227561	5/14 (36%)
		LEM_ANKL2	208..250	CDD:240591
		Cauli_VI	<360..391	CDD:396314	7/30 (23%)
		Ank_2	<517..>591	CDD:423045	30/73 (41%)
		ANK repeat	552..585	CDD:293786	9/32 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343662
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	211	1.000	Inparanoid score	I3573
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D259185at33208
OrthoFinder	1	1.000	-	-		FOG0007072
OrthoInspector	1	1.000	-	-		oto98351
orthoMCL	1	0.900	-	-		OOG6_107599
Panther	1	1.100	-	-	LDO	PTHR12349
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5160
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.900