Protein Alignment Ankle2 and ANKLE2

DIOPT Version :9

• Sequence 1: NP_573221.2
• Gene: Ankle2 / 32732
• FlyBaseID: FBgn0028343
• Length: 1174
• Species: Drosophila melanogaster
• Sequence 2: NP_055929.1
• Gene: ANKLE2 / 23141
• HGNCID: 29101
• Length: 938
• Species: Homo sapiens
• Alignment Length: 1146
• Identity: 267/1146 - (23%)
• Similarity: 397/1146 - (34%)
• Gaps: 398/1146 - (34%)

  Fly    10 PTSKAGCFEGSVSQCIGSIAAVNIKPSNPASGSASVASGSPSGSAASVQTGNADDGSAATKYEDP 74
            ||.:||..|   .:..|  .:|.:.|....:.::...|..||      .|.....|:.|:| |.|
Human   145 PTDQAGFSE---DRDFG--YSVGLNPPEEEAVTSKTCSVPPS------DTDTYRAGATASK-EPP 197

  Fly    75 ----------DYPPDSPLWLIFTEKSKALDILRHYKEARLREFPNLEQAESYVQFGFESIEALKR 129
                      |.|..:....::..|.:||..::..|.:|.:.|...|.||.:.          :.
Human   198 LYYGVCPVYEDVPARNERIYVYENKKEALQAVKMIKGSRFKAFSTREDAEKFA----------RG 252

  Fly   130 FCKAKPESKPIPIISGSGYKSSPTSTDNSCSSSPTGNGSGFIIPLGSNSSMSN-LLLSDSPTSSP 193
            .|               .|..||:.|....|...|.       ||.||..:.: |.||:|.|.:.
Human   253 IC---------------DYFPSPSKTSLPLSPVKTA-------PLFSNDRLKDGLCLSESETVNK 295

  Fly   194 SSSSNVIANGRQQQMQQQQQQQPQQPDVSGEGPPFRAPTKQEL-VEFRKQIEGGHIDRVKRIIWE 257
            ..:::                             ::.|..|:| .:.||.:|.|..|....:||.
Human   296 ERANS-----------------------------YKNPRTQDLTAKLRKAVEKGEEDTFSDLIWS 331

  Fly   258 NPRFLISSGDTPTSLKEGCRYNAMHICAQVNKARIAQLLLKTISDREFTQLYVGKKGSGKMCAAL 322
            |||:||.|||.||.::||||||.||:.|:.|:|.|.||.|..:.:.:|.:|.........:...:
Human   332 NPRYLIGSGDNPTIVQEGCRYNVMHVAAKENQASICQLTLDVLENPDFMRLMYPDDDEAMLQKRI 396

  Fly   323 NISLLDYYLNMPDKGRGETPLHFAAKNGHVAMVEVLVSYP-ECKSLRNHEGKEPKEIICLRNANA 386
            .. ::|.|||.|||...:||||||.|.|:..:|.||.|:. ..|:.||...|.|:::||.|:.|.
Human   397 RY-VVDLYLNTPDKMGYDTPLHFACKFGNADVVNVLSSHHLIVKNSRNKYDKTPEDVICERSKNK 460

  Fly   387 THVTIKKLELLLYDPHFVPVLRSQSNTLPPKVGQPFSPKDPPNLQHKADDYEGLSVD--LAISAL 449
            :....:::...|...::||:||:: .|..|.:|:.:||.......| ...|.|...|  |.:.|.
Human   461 SVELKERIREYLKGHYYVPLLRAE-ETSSPVIGELWSPDQTAEASH-VSRYGGSPRDPVLTLRAF 523

  Fly   450 AGPMSREKAMNFYRRWKTPPRVSNNVMSPLAGSPFSSPVKVTPSKSIFDRSAGNSSPVHSGRRVL 514
            |||:|..||.:|.:.||||||                            ..||
Human   524 AGPLSPAKAEDFRKLWKTPPR----------------------------EKAG------------ 548

  Fly   515 FSPLAEATSSPKPTKNVPNGTNECEHNNNNVKPVYPLEFPATPIRKMKPDLFMAYRNNNSFDSPS 579
                                                               |:
Human   549 ---------------------------------------------------FL------------ 550

  Fly   580 LADDSQILDMSLSRSLNASLNDSFRERHIKNTDIEKGLEVVGRQLARQEQLEWREYWDFLDSFLD 644
                                      .|:|.:|.|:|.|.|||:||.:....|.|||:||..|:|
Human   551 --------------------------HHVKKSDPERGFERVGRELAHELGYPWVEYWEFLGCFVD 589

  Fly   645 IGTTEGLARLEAYFLEKTEQQADKSETVWNFAHLHQYFDSMAGEQQQQLRKDKNEAAGATSPSAG 709
            :.:.|||.|||.|..::...:..:.||               ||::...| ||...:|:.|.|
Human   590 LSSQEGLQRLEEYLTQQEIGKKAQQET---------------GEREASCR-DKATTSGSNSIS-- 636

  Fly   710 VMTPYTCVEKSLQVFAKRITKTLINKIGNMVSINDTLLCELKRLKSLIVSFKDDARFISVDFSKV 774
                                      :...:..:|..|.|:|..::.       ||..|   ...
Human   637 --------------------------VRAFLDEDDMSLEEIKNRQNA-------ARNNS---PPT 665

  Fly   775 HSRIAHLVASYVTHSQEVSV----------AMRLQLLQMLRSLRQLLADE----RGREQHLGCVC 825
            .....|...|.....||..:          :.|..|...|...|.|....    ||.|.||
Human   666 VGAFGHTRCSAFPLEQEADLIEAAEPGGPHSSRNGLCHPLNHSRTLAGKRPKAPRGEEAHL---- 726

  Fly   826 ASLLLMLEQAPTSAVHLPDTLKTEELCCAAWETEQCCACLWDANLSRKTSRRKRTKSLRAAAVVQ 890
                     .|.|.:    |::.::|                 ||..               :.:
Human   727 ---------PPVSDL----TVEFDKL-----------------NLQN---------------IGR 746

  Fly   891 SQGQLQDTSGSTGSSALHASLGVGSTSLGASRVVASASKDAWRRQQSDDEDYDSDEQVIFFDCTN 955
            |..:..|.|..|....|            .||:.| ..:|......:|.
Human   747 SVSKTPDESTKTKDQIL------------TSRINA-VERDLLEPSPADQ---------------- 782

  Fly   956 VTLPYG-SSSEDEENFRTPPQSLSPG-------ISMDLEPRYELFIFGNEPTKRDLDVLNALSNV 1012
              |..| ..:|.|.:.|....||||.       :.:..||...||:||.||:|.|.|||.||...
Human   783 --LGNGHRRTESEMSARIAKMSLSPSSPRHEDQLEVTREPARRLFLFGEEPSKLDQDVLAALECA 845

  Fly  1013 DIDKETLPHVYAWKTAMESYSCAEMNLFPSPRNVK---------VQKPEPWYSGTSSSHNSQPLL 1068
            |:|....|.|:.||:|:..||.::...:|||. ||         :..|..:..|.:|...|.|
Human   846 DVDPHQFPAVHRWKSAVLCYSPSDRQSWPSPA-VKGRFKSQLPDLSGPHSYSPGRNSVAGSNP-- 907

  Fly  1069 HPKRLLATPKLNAVVSGRRGSGPLTAPVTPRLARTPSAASI 1109
                  |.|.|.:  .||  ..|:......|:||....|::
Human   908 ------AKPGLGS--PGR--YSPVHGSQLRRMARLAELAAL 938

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ankle2	NP_573221.2	ANK repeat	280..335	CDD:293786	15/54 (28%)
		Ank_2	281..361	CDD:403870	29/79 (37%)
		ANK repeat	337..369	CDD:293786	13/32 (41%)
ANKLE2	NP_055929.1	LEM_ANKL2	71..113	CDD:240591
		Cauli_VI	<218..249	CDD:279957	9/30 (30%)
		ANK	334..464	CDD:238125	53/130 (41%)
		ANK repeat	355..386	CDD:293786	11/30 (37%)
		Ank_2	356..435	CDD:289560	29/79 (37%)
		ANK repeat	410..443	CDD:293786	13/32 (41%)
		ANK	411..440		12/28 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	609..636		9/42 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	870..924		16/66 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149767
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2CMEJ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	223	1.000	Inparanoid score	I3536
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D259185at33208
OrthoFinder	1	1.000	-	-		FOG0007072
OrthoInspector	1	1.000	-	-		oto91267
orthoMCL	1	0.900	-	-		OOG6_107599
Panther	1	1.100	-	-	LDO	PTHR12349
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5160
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.760