Protein Alignment Ankle2 and lem-4

DIOPT Version :9

• Sequence 1: NP_573221.2
• Gene: Ankle2 / 32732
• FlyBaseID: FBgn0028343
• Length: 1174
• Species: Drosophila melanogaster
• Sequence 2: NP_001023514.1
• Gene: lem-4 / 176911
• WormBaseID: WBGene00021945
• Length: 603
• Species: Caenorhabditis elegans
• Alignment Length: 511
• Identity: 121/511 - (23%)
• Similarity: 181/511 - (35%)
• Gaps: 200/511 - (39%)

  Fly   179 SMSNLLLSDSPTSSPSSSSNVIANGRQQQMQQQQQQQPQQPDVSGEGPPFRAPTKQELVEFRKQI 243
            :|..|...|:|| :|.:...|               .|.:|:     .||....:.::.||:|.:
 Worm    84 AMDFLAYGDAPT-TPKTVPPV---------------APTEPN-----SPFSGVNRIQMNEFKKYV 127

  Fly   244 EGGHIDRVKRIIWENPRFLISS-GDTPTSLKEGCRYNAMHICAQVNKARIAQLLLKTISDREF-T 306
            |.|.::...|::..|||||::: ||..:.:.||.||||:||.|:..:..|...:|:.|.:.:| .
 Worm   128 EKGDMENFLRLVDSNPRFLVNTGGDVASIVMEGFRYNALHIAAKAGQTEIIAKILELIQNIDFLI 192

  Fly   307 QLYVGKKGSGKMCAAL-NISLLDYYLNMPDKGRGETPLHFAAKNGHVAMVEVLVSYPEC-KSLRN 369
            :||    |:|.....| .|::||.|||.||||..:||||||:|.|.:.:|.||...... ::|.|
 Worm   193 RLY----GTGADDVTLRKINILDSYLNTPDKGNSDTPLHFASKFGKIGVVRVLTENSATDRTLLN 253

  Fly   370 HEGK------------EPKEIICLRNANATHVTIKKLELLLYDPHFVPVLRSQSNTLPPKVGQPF 422
            ..||            |.|:::    ....|:.|:...:.|   |..|...|...|:..|....:
 Worm   254 KSGKSALDCAGERYTGEDKDMV----QRDIHLAIEGFYVFL---HRNPTTGSTQLTVSQKPPATY 311

  Fly   423 SPKDPPNLQHKADDYEGLSVDLAISALAGPMSREK-AMNFYRRWKTPPRVSNNVMSPLAGSPFSS 486
            |...             .:..:.:||.|||...|: |.:|.:.|:|
 Worm   312 STSP-------------TTATVTVSAQAGPFFTEREARDFAKSWQT------------------- 344

  Fly   487 PVKVTPSKSIFDRSAGNSSPVHSGRRVLFSPLAEATSSPKPTKNVPNGTNECEHNNNNVKPVYPL 551
                          ||
 Worm   345 --------------AG------------------------------------------------- 346

  Fly   552 EFPATPIRKMKPDLFMAYRNNNSFDSPSLADDSQILDMSLSRSLNASLNDSFRERHIKNTDIEKG 616
                                                                  :.:|.||.:||
 Worm   347 ------------------------------------------------------KELKRTDFDKG 357

  Fly   617 LEVVGRQLARQEQLEWREYWDFLDS--FLDIGTTEGLARLEAYFLEKTEQQADKSE 670
            .|.|||.||.|.:..|||.|.||.|  .||:|:.:||..|||:..||.......||
 Worm   358 WERVGRVLAEQSEAMWRETWHFLGSMELLDLGSEQGLGVLEAFLREKRRGNLRNSE 413

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ankle2	NP_573221.2	ANK repeat	280..335	CDD:293786	19/56 (34%)
		Ank_2	281..361	CDD:403870	33/81 (41%)
		ANK repeat	337..369	CDD:293786	13/32 (41%)
lem-4	NP_001023514.1	ANK	144..263	CDD:238125	48/122 (39%)
		Ank_4	162..241	CDD:290365	35/82 (43%)
		ANK repeat	165..218	CDD:293786	19/56 (34%)
		ANK repeat	220..253	CDD:293786	13/32 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161172
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D259185at33208
OrthoFinder	1	1.000	-	-		FOG0007072
OrthoInspector	1	1.000	-	-		oto17280
orthoMCL	1	0.900	-	-		OOG6_107599
Panther	1	1.100	-	-	LDO	PTHR12349
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2398
SonicParanoid	1	1.000	-	-		X5160
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.880