Protein Alignment ppk23 and asic1a

DIOPT Version :10

• Sequence 1: NP_001097011.1
• Gene: ppk23 / 32731
• FlyBaseID: FBgn0030844
• Length: 591
• Species: Drosophila melanogaster
• Sequence 2: NP_999955.1
• Gene: asic1a / 791696
• ZFINID: ZDB-GENE-040513-2
• Length: 501
• Species: Danio rerio
• Alignment Length: 567
• Identity: 121/567 - (21%)
• Similarity: 197/567 - (34%)
• Gaps: 171/567 - (30%)

  Fly    34 FFQNSTLHGVRYIAESGRPIGEKFMWFCFTSIGAVTALVIIMSLWEKFQTNPTITGLDTDFHNQN 98
            |...|||||:.:|....:...:..:|..|........:.:.:...:.:...|.:|.|| :.....
Zfish    26 FAHTSTLHGISHIFSYEKITAKCCLWVVFFLSSLTFLMYVCIDRIQFYLEYPHVTKLD-EITTPV 89

  Fly    99 VVFPTTVVCPEAAFDHDK-TYEKVYNTLANYDEAQAQMYTPFLRILTSLNFENVRDAKVLSQSIP 162
            :|||...:|...:....: |...:|:.            ...|.:|.|.:  .||:|.::.:|:.
Zfish    90 MVFPAVTICNLNSIRFSRITRNDLYHA------------GELLALLNSRH--EVREAHLVEESVM 140

  Fly   163 QNLLDAHTIRE--------WAF---EGHIDCKNVFVSCKYRDEDIPC-CDHFEPIYTEHGFCYAF 215
            :.|......|.        |.|   .|| |.|::.:||::|..  || .:.|..::|.:|.||.|
Zfish   141 EVLKSKTDFRSFKPRHFNMWEFYNRTGH-DIKDMLLSCQFRGS--PCRPEDFSVVFTRYGKCYTF 202

  Fly   216 NSRFKSTPTEDVKTGAPHDL-----YETDKKWALFFIPNSTSRIFIFSNEEYFGSDFNAQI-DWS 274
            ||.....|...||.|..:.|     .:.|:     ::|     ::..|:|..|.:....|| ...
Zfish   203 NSGETGPPRVSVKGGMGNGLEIMLDIQQDE-----YLP-----VWGESDESSFEAGIKVQIHSQD 257

  Fly   275 EPQLVEVRISKKNTYTTDDARQLSIGQ----RKCIFSDEVKLNYFP----------------DAY 319
            ||..::               ||..|.    :..:...|.:|.|.|                .||
Zfish   258 EPPFID---------------QLGFGVAPGFQTFVSCQEQRLVYLPAPWGSCKSTPPSSDYFRAY 307

  Fly   320 TFSSCMKQCRMNKAIKLCKC-------NPPFYKPIRELSCVINIFTNLIAYILLLYLTPKANVPM 377
            :.|:|...|.....::.|.|       :.|:..|:                   ||       ..
Zfish   308 SISACRTDCETRYLVENCNCRMVHMPGDAPYCTPV-------------------LY-------KE 346

  Fly   378 CSIKDFDCLDEFKSNITNIKDCLQCELSCSKTVF-------------NIDKLIKMSDRPES---- 425
            |:....|.|.|..|      |...||..|:.|.:             ::..|.|...:.|.
Zfish   347 CAHPALDFLVETDS------DYCSCETPCNITRYSKELSFVKIPSKASVKYLAKKYSKSEKYITE 405

  Fly   426 ----LGVLVEFLTWPIIRYKR--EVLFGWVDLLVSFGGIASLFLGFSLLSGVEIIYYFTLRACCM 484
                |.|..|.|.:..|..::  ||    ..||...||...||:|.|:|:.:|:..|
Zfish   406 NVMVLDVFFEALNYETIEQRKAYEV----AGLLGDIGGQMGLFIGASILTILELFDY-------- 458

  Fly   485 VYKNRQELYEIEEKIRQEPPPKIDLKLSLKSHNPRIGDTPTSAVLKV 531
                   |||: .|.|.       .:.|.|.|:....:|..:||..:
Zfish   459 -------LYEV-MKYRL-------CRCSNKKHHNNNNNTDHNAVFSL 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk23	NP_001097011.1	ASC	34..476	CDD:459966	109/510 (21%)
asic1a	NP_999955.1	ENaC	23..469	CDD:273304	115/544 (21%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:Q1XA76	446..448		1/1 (100%)