DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk23 and Asic5

DIOPT Version :9

Sequence 1:	NP_001097011.1	Gene:	ppk23 / 32731	FlyBaseID:	FBgn0030844	Length:	591	Species:	Drosophila melanogaster
Sequence 2:	NP_071563.1	Gene:	Asic5 / 63866	RGDID:	69295	Length:	495	Species:	Rattus norvegicus

Alignment Length:	554	Identity:	108/554 - (19%)
Similarity:	198/554 - (35%)	Gaps:	180/554 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 EFFQNSTLHGVRYIAESGRPIGEKFMWFCFTSIGAVTALVIIMSLWEKFQ--TN----PTITGLD 91
            :|..:::.||:..||::...: .|.:|.... :|:|:.||     |:.:.  .|    ||.|.::
  Rat    40 DFAISTSFHGIHNIAQNQNKV-RKVIWLSVV-LGSVSLLV-----WQIYSRLVNYFMWPTTTSIE 97

  Fly    92 TDFHNQNVVFPTTVVCPEAAFDHDKTYEKVYNTLANYDEAQAQMYTPF-------------LRIL 143
            ..: .:.:.||....|                   |.:..|.:..:.|             || |
  Rat    98 VQY-VEKIEFPAVTFC-------------------NLNRFQTEAVSRFGIIFFLWDIVSKVLR-L 141

  Fly   144 TSLNFENVRDAKVLSQSIPQNLLDAH---TIREWA-----FEGHIDCKNVFVSCKYRDEDIPCCD 200
            ..::..|....:.|      :.:.:|   :|.|:.     :..|    :..|.|::..:   .||
  Rat   142 QEISGNNTGSPEAL------DFVASHRNFSITEFVKNNGFYLNH----DTLVHCEFFGK---TCD 193

  Fly   201 --HFEPIYTEHGFCYAFNSRFKSTPTEDVKTGAPHDLYETDKKWALFFIPNSTS------RIFIF 257
              .|:.::||:|.|:.||.      .|:|::                  .|..|      ::.:.
  Rat   194 PKDFKHVFTEYGNCFTFNY------GENVQS------------------KNKVSVSGRGLKLLLD 234

  Fly   258 SNEEYF-----------GSDFNAQIDWSEPQLVEVRISKK-NTYTTDDARQL-SIGQR----KCI 305
            .::|.|           |..|.......|||...:.:|.. ..:.....||| :|.|.    :|
  Rat   235 VHQEEFTDNPVPGFADAGVIFVIHSPKKEPQFDGLGLSSPVGMHARVTIRQLKTIHQEYPWGEC- 298

  Fly   306 FSDEVKLNYFPDAYTFSSCMKQCRMNKAIKLCKCNPPFYKPIRELSCVINIFTNLIAYILLLYLT 370
             :.::||..| ..|:...|:|:|:.....:||.|.|                          :|.
  Rat   299 -NPDIKLRNF-TTYSTYGCLKECKAKHIQRLCGCLP--------------------------FLL 335

  Fly   371 PKANVPMCSIKDFDCLDEFKSNITNIKDCL------QCELSCSKTVFN----------------I 413
            |...|....:|.::|:.....:|.....|.      .|.:.|.:|.:.                :
  Rat   336 PGNGVECDLLKYYNCVSPILDHIERKGLCTMGTHNSSCPVPCEETEYPATIAYSTFPSQRATKFL 400

  Fly   414 DKLIKMSD---RPESLGVLVEF--LTWPIIRYKREVLFGWVDLLVSFGGIASLFLGFSLLSGVEI 473
            .|.:..|.   |...:.:.:.:  |.:.|.:.::.|  ...:||...||...||.|.||::.:||
  Rat   401 AKKLNQSQEYIRENLVNIEINYSDLNYKITQQQKAV--SVPELLADVGGQLGLFCGASLITIIEI 463

  Fly   474 I-YYFTLRACCMVYKNRQELYEIEEKIRQEPPPK 506
            | |.||......::    .|.:|.|.|::..||:
  Rat   464 IEYLFTSFYWVFIF----FLLKILEMIQRTSPPQ 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk23	NP_001097011.1	ASC	34..476	CDD:279230	99/521 (19%)
Asic5	NP_071563.1	deg-1	40..465	CDD:273309	98/520 (19%)
Asic5	NP_071563.1	ASC	41..466	CDD:279230	99/520 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820