Protein Alignment ppk23 and Asic5

DIOPT Version :10

• Sequence 1: NP_001097011.1
• Gene: ppk23 / 32731
• FlyBaseID: FBgn0030844
• Length: 591
• Species: Drosophila melanogaster
• Sequence 2: NP_071563.1
• Gene: Asic5 / 63866
• RGDID: 69295
• Length: 495
• Species: Rattus norvegicus
• Alignment Length: 554
• Identity: 108/554 - (19%)
• Similarity: 198/554 - (35%)
• Gaps: 180/554 - (32%)

  Fly    33 EFFQNSTLHGVRYIAESGRPIGEKFMWFCFTSIGAVTALVIIMSLWEKFQ--TN----PTITGLD 91
            :|..:::.||:..||::...: .|.:|.... :|:|:.||     |:.:.  .|    ||.|.::
  Rat    40 DFAISTSFHGIHNIAQNQNKV-RKVIWLSVV-LGSVSLLV-----WQIYSRLVNYFMWPTTTSIE 97

  Fly    92 TDFHNQNVVFPTTVVCPEAAFDHDKTYEKVYNTLANYDEAQAQMYTPF-------------LRIL 143
            ..: .:.:.||....|                   |.:..|.:..:.|             || |
  Rat    98 VQY-VEKIEFPAVTFC-------------------NLNRFQTEAVSRFGIIFFLWDIVSKVLR-L 141

  Fly   144 TSLNFENVRDAKVLSQSIPQNLLDAH---TIREWA-----FEGHIDCKNVFVSCKYRDEDIPCCD 200
            ..::..|....:.|      :.:.:|   :|.|:.     :..|    :..|.|::..:   .||
  Rat   142 QEISGNNTGSPEAL------DFVASHRNFSITEFVKNNGFYLNH----DTLVHCEFFGK---TCD 193

  Fly   201 --HFEPIYTEHGFCYAFNSRFKSTPTEDVKTGAPHDLYETDKKWALFFIPNSTS------RIFIF 257
              .|:.::||:|.|:.||.      .|:|::                  .|..|      ::.:.
  Rat   194 PKDFKHVFTEYGNCFTFNY------GENVQS------------------KNKVSVSGRGLKLLLD 234

  Fly   258 SNEEYF-----------GSDFNAQIDWSEPQLVEVRISKK-NTYTTDDARQL-SIGQR----KCI 305
            .::|.|           |..|.......|||...:.:|.. ..:.....||| :|.|.    :|
  Rat   235 VHQEEFTDNPVPGFADAGVIFVIHSPKKEPQFDGLGLSSPVGMHARVTIRQLKTIHQEYPWGEC- 298

  Fly   306 FSDEVKLNYFPDAYTFSSCMKQCRMNKAIKLCKCNPPFYKPIRELSCVINIFTNLIAYILLLYLT 370
             :.::||..| ..|:...|:|:|:.....:||.|.|                          :|.
  Rat   299 -NPDIKLRNF-TTYSTYGCLKECKAKHIQRLCGCLP--------------------------FLL 335

  Fly   371 PKANVPMCSIKDFDCLDEFKSNITNIKDCL------QCELSCSKTVFN----------------I 413
            |...|....:|.::|:.....:|.....|.      .|.:.|.:|.:.                :
  Rat   336 PGNGVECDLLKYYNCVSPILDHIERKGLCTMGTHNSSCPVPCEETEYPATIAYSTFPSQRATKFL 400

  Fly   414 DKLIKMSD---RPESLGVLVEF--LTWPIIRYKREVLFGWVDLLVSFGGIASLFLGFSLLSGVEI 473
            .|.:..|.   |...:.:.:.:  |.:.|.:.::.|  ...:||...||...||.|.||::.:||
  Rat   401 AKKLNQSQEYIRENLVNIEINYSDLNYKITQQQKAV--SVPELLADVGGQLGLFCGASLITIIEI 463

  Fly   474 I-YYFTLRACCMVYKNRQELYEIEEKIRQEPPPK 506
            | |.||......::    .|.:|.|.|::..||:
  Rat   464 IEYLFTSFYWVFIF----FLLKILEMIQRTSPPQ 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk23	NP_001097011.1	ASC	34..476	CDD:459966	99/521 (19%)
Asic5	NP_071563.1	Binds the plasma membrane and stabilizes the channel in the closed state. /evidence=ECO:0000269|PubMed:27679529	1..30
		ASC	41..466	CDD:459966	99/520 (19%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	454..456		1/1 (100%)