Protein Alignment ppk23 and ASIC5

DIOPT Version :10

• Sequence 1: NP_001097011.1
• Gene: ppk23 / 32731
• FlyBaseID: FBgn0030844
• Length: 591
• Species: Drosophila melanogaster
• Sequence 2: NP_059115.1
• Gene: ASIC5 / 51802
• HGNCID: 17537
• Length: 505
• Species: Homo sapiens
• Alignment Length: 537
• Identity: 116/537 - (21%)
• Similarity: 191/537 - (35%)
• Gaps: 146/537 - (27%)

  Fly    33 EFFQNSTLHGVRYIAESGRPIGEKFMWFCFT--SIGAVTALVIIMSLWEKFQTNPTITGLDTDFH 95
            :|..:::.||:..|.::...| .:.:|....  |:..||..:.|..|  .:.|.||.|.::..:
Human    40 DFAISTSFHGIHNIVQNRSKI-RRVLWLVVVLGSVSLVTWQIYIRLL--NYFTWPTTTSIEVQY- 100

  Fly    96 NQNVVFPTTVVCPEAAFDHDKTYE--------KVYNTLANYDEAQAQMYTPFLRILTSLNFENVR 152
            .:.:.||....|....|..|...:        .:.:.:.:..|..|             |....|
Human   101 VEKMEFPAVTFCNLNRFQTDAVAKFGVIFFLWHIVSKVLHLQEITA-------------NSTGSR 152

  Fly   153 DAKVLSQSIPQNLLDAHTIREWAF----EGHIDCKNVFVSCKYRDEDIPCCDHFEPIYTEHGFCY 213
            :|...:.| .||......||...|    ...:||:.....|..:|        |..::||:|.|:
Human   153 EATDFAAS-HQNFSIVEFIRNKGFYLNNSTLLDCEFFGKPCSPKD--------FAHVFTEYGNCF 208

  Fly   214 AFNSRFKSTPTEDVKTGAPH-DLYETDKKWALFFIPNSTSRIFIFS-NEEYFGSDFNAQIDWSEP 276
            .||                | :..:..:|.::    :......:|: |:|.|..  |..:.:.:.
Human   209 TFN----------------HGETLQAKRKVSV----SGRGLSLLFNVNQEAFTD--NPALGFVDA 251

  Fly   277 QLVEVRISKKNTYTTDDARQLS---------IGQRKCIFSD--------EVKLNYFPDAYTFSSC 324
            .::.|..|.|.....|....||         |.|.|.:..:        .:||..| .:|:.|.|
Human   252 GIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNPNIKLQNF-SSYSTSGC 315

  Fly   325 MKQCRMNKAIKLCKCNPPFYKPIRELSCVINIFTNLIAYILLLYLTPKANVPMCSIKDFDCLD-- 387
            :|:|:.....|.|.| .||..|...:.|.:.                         |.|.|:.
Human   316 LKECKAQHIKKQCGC-VPFLLPGYGIECDLQ-------------------------KYFSCVSPV 354

  Fly   388 ----EFKSNITNIKDCLQCELSC---------SKTVFNIDKLIKMSDRP---------ESLGVLV 430
                |||...|.......|.:||         |.:.|...|.:|...:.         |:| |.:
Human   355 LDHIEFKDLCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKYIRENL-VKI 418

  Fly   431 EF----LTWPIIRYKREVLFGWVDLLVSFGGIASLFLGFSLLSGVEII-YYFT-LRACCMVYKNR 489
            |.    |.:.|.:.::.|...  :||...||...||.|.||::.:||| |.|| ....|:.:
Human   419 EINYSDLNYKITQQQKAVSVS--ELLADLGGQLGLFCGASLITIIEIIEYLFTNFYWICIFF--- 478

  Fly   490 QELYEIEEKIRQEPPPK 506
              |.:|.|..:..|||:
Human   479 --LLKISEMTQWTPPPQ 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk23	NP_001097011.1	ASC	34..476	CDD:459966	106/503 (21%)
ASIC5	NP_059115.1	Binds the plasma membrane and stabilizes the channel in the closed state. /evidence=ECO:0000250|UniProtKB:Q9R0W5	1..30
		ASC	41..466	CDD:459966	106/502 (21%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	454..456		1/1 (100%)