Protein Alignment ppk23 and ASIC5

DIOPT Version :9

• Sequence 1: NP_001097011.1
• Gene: ppk23 / 32731
• FlyBaseID: FBgn0030844
• Length: 591
• Species: Drosophila melanogaster
• Sequence 2: NP_059115.1
• Gene: ASIC5 / 51802
• HGNCID: 17537
• Length: 505
• Species: Homo sapiens
• Alignment Length: 537
• Identity: 116/537 - (21%)
• Similarity: 191/537 - (35%)
• Gaps: 146/537 - (27%)

  Fly    33 EFFQNSTLHGVRYIAESGRPIGEKFMWFCFT--SIGAVTALVIIMSLWEKFQTNPTITGLDTDFH 95
            :|..:::.||:..|.::...| .:.:|....  |:..||..:.|..|  .:.|.||.|.::..:
Human    40 DFAISTSFHGIHNIVQNRSKI-RRVLWLVVVLGSVSLVTWQIYIRLL--NYFTWPTTTSIEVQY- 100

  Fly    96 NQNVVFPTTVVCPEAAFDHDKTYE--------KVYNTLANYDEAQAQMYTPFLRILTSLNFENVR 152
            .:.:.||....|....|..|...:        .:.:.:.:..|..|             |....|
Human   101 VEKMEFPAVTFCNLNRFQTDAVAKFGVIFFLWHIVSKVLHLQEITA-------------NSTGSR 152

  Fly   153 DAKVLSQSIPQNLLDAHTIREWAF----EGHIDCKNVFVSCKYRDEDIPCCDHFEPIYTEHGFCY 213
            :|...:.| .||......||...|    ...:||:.....|..:|        |..::||:|.|:
Human   153 EATDFAAS-HQNFSIVEFIRNKGFYLNNSTLLDCEFFGKPCSPKD--------FAHVFTEYGNCF 208

  Fly   214 AFNSRFKSTPTEDVKTGAPH-DLYETDKKWALFFIPNSTSRIFIFS-NEEYFGSDFNAQIDWSEP 276
            .||                | :..:..:|.::    :......:|: |:|.|..  |..:.:.:.
Human   209 TFN----------------HGETLQAKRKVSV----SGRGLSLLFNVNQEAFTD--NPALGFVDA 251

  Fly   277 QLVEVRISKKNTYTTDDARQLS---------IGQRKCIFSD--------EVKLNYFPDAYTFSSC 324
            .::.|..|.|.....|....||         |.|.|.:..:        .:||..| .:|:.|.|
Human   252 GIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNPNIKLQNF-SSYSTSGC 315

  Fly   325 MKQCRMNKAIKLCKCNPPFYKPIRELSCVINIFTNLIAYILLLYLTPKANVPMCSIKDFDCLD-- 387
            :|:|:.....|.|.| .||..|...:.|.:.                         |.|.|:.
Human   316 LKECKAQHIKKQCGC-VPFLLPGYGIECDLQ-------------------------KYFSCVSPV 354

  Fly   388 ----EFKSNITNIKDCLQCELSC---------SKTVFNIDKLIKMSDRP---------ESLGVLV 430
                |||...|.......|.:||         |.:.|...|.:|...:.         |:| |.:
Human   355 LDHIEFKDLCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKYIRENL-VKI 418

  Fly   431 EF----LTWPIIRYKREVLFGWVDLLVSFGGIASLFLGFSLLSGVEII-YYFT-LRACCMVYKNR 489
            |.    |.:.|.:.::.|...  :||...||...||.|.||::.:||| |.|| ....|:.:
Human   419 EINYSDLNYKITQQQKAVSVS--ELLADLGGQLGLFCGASLITIIEIIEYLFTNFYWICIFF--- 478

  Fly   490 QELYEIEEKIRQEPPPK 506
              |.:|.|..:..|||:
Human   479 --LLKISEMTQWTPPPQ 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk23	NP_001097011.1	ASC	34..476	CDD:279230	106/503 (21%)
ASIC5	NP_059115.1	ASC	41..466	CDD:279230	106/502 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820