DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk23 and asic4b

DIOPT Version :9

Sequence 1:	NP_001097011.1	Gene:	ppk23 / 32731	FlyBaseID:	FBgn0030844	Length:	591	Species:	Drosophila melanogaster
Sequence 2:	NP_999951.1	Gene:	asic4b / 407667	ZFINID:	ZDB-GENE-040513-6	Length:	558	Species:	Danio rerio

Alignment Length:	590	Identity:	120/590 - (20%)
Similarity:	212/590 - (35%)	Gaps:	184/590 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 FFQNSTLHGV-RYIAESGRPIGEKFMW--FCFTSIGAVTALVIIMSLWE--KFQTNPTITGLDTD 93
            |..:|:|||: |.:..|.|....:.:|  ....|:|    |.:..:.|.  .:...|.:..|..:
Zfish    47 FASSSSLHGLARALGTSERLGFRQTLWGLALLVSLG----LFLYQATWSAATYLERPHLAALREE 107

  Fly    94 FHNQNVVFPTTVVCPEAAFDHDK-TYEKVYNTLANYDEAQAQMYTPFLRILTSL---NFENVRDA 154
            ...: :.||...:|....|.... |...:|: |||               ||.|   :.:..|.:
Zfish   108 TRRE-LTFPAITLCNVNRFRFSALTDADIYH-LAN---------------LTGLPPKSRKGHRPS 155

  Fly   155 KVLSQSIPQNLLDAHTIREWAFE--GHIDCKNVFVSCKYRDEDIPCCDHFEPIYTEHGFCYAFNS 217
            ::  |..|.|:||       .|:  || ..:::..||.:..::....| |..:||.:|.||.||.
Zfish   156 EL--QYPPPNMLD-------IFQRTGH-QLEDMLKSCNFSGQNCSSED-FSVVYTRYGKCYTFNG 209

  Fly   218 RFKSTPTEDVKTGAPHDL-----YETDKKWALFFIPNSTSRIFIFSNEEYFGSDFNAQI-DWSEP 276
            . |::|....:.|..:.|     .:.|:     ::|     |:..:||....:....|| ..:||
Zfish   210 N-KTSPKRVRQGGTGNGLEMMLDIQQDE-----YLP-----IWRETNETTLEAGIRVQIHSQNEP 263

  Fly   277 QLVEVRISKKNTYTTDDARQL----SIGQRKCIFSDEVKLNYFP-----------------DAYT 320
            ..:               .||    |.|.:..:...|.:|.|.|                 |.|:
Zfish   264 PYI---------------HQLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCRASSEPVIPGYDTYS 313

  Fly   321 FSSCMKQCRMNKAIKLCKCNPPFYKPIRELSCVINIFTNLIAYILLLYLTPKANVPMCSIKDFDC 385
            .|:|...|...:..:.|.|.                         ::::...|::  |:.....|
Zfish   314 VSACRLHCESTQVQRECNCR-------------------------MVHMPGDADI--CAPSKIKC 351

  Fly   386 LDEFKSNI-TNIKDCLQCELSCSKTVFNID-KLIKMSDRPES--------------------LGV 428
            :|:..::: .:..|...||..|:.|.:..: .::|:..|..:                    |.:
Zfish   352 VDKALASLQKSTGDSCPCETPCNLTRYGKELSMVKIPSRGSARYLSRKYQKSEEYIRDNFLILDI 416

  Fly   429 LVEFLTWPIIRYKREVLFGWVDLLVSFGGIASLFLGFSLLSGVEIIYYFTLRACCMVYKNRQELY 493
            ..|.|.:..|..|:  .:....||...||...||:|.|:|:.:||:.|               :|
Zfish   417 FFEALNYETIEQKK--AYDIAGLLGDIGGQMGLFIGASILTILEILDY---------------IY 464

  Fly   494 EI-EEKIRQEPPPK---------------IDLKLSLKSHNPRIGDTPTSAV------LKVKPAEE 536
            |: :.||:|...||               |....:|:..|.:...|..:..      :|||.|.:
Zfish   465 EVAKNKIKQLLKPKKSQKQTNQRNLIQEQIQRTKNLREQNLKAQLTAGAIATVRFEEVKVKAAND 529

  Fly   537 SAGPN 541
            .|.|:
Zfish   530 VAQPH 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk23	NP_001097011.1	ASC	34..476	CDD:279230	102/501 (20%)
asic4b	NP_999951.1	ASC	54..497	CDD:295594	108/544 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920