Protein Alignment ppk23 and ASIC2

DIOPT Version :9

• Sequence 1: NP_001097011.1
• Gene: ppk23 / 32731
• FlyBaseID: FBgn0030844
• Length: 591
• Species: Drosophila melanogaster
• Sequence 2: NP_899233.1
• Gene: ASIC2 / 40
• HGNCID: 99
• Length: 563
• Species: Homo sapiens
• Alignment Length: 588
• Identity: 131/588 - (22%)
• Similarity: 221/588 - (37%)
• Gaps: 164/588 - (27%)

  Fly    14 QRFLETLVIFRRSLIYQTKEFFQNSTLHGVRYIAESGRPIGEKF----MW---FCFTSIGAVTAL 71
            :|.|:...:.||.     :.....:.|||:|::.......|..|    :|   || ||.|    |
Human    45 ERALQGPGVARRG-----RPSLSRAKLHGLRHMCAGRTAAGGSFQRRALWVLAFC-TSFG----L 99

  Fly    72 VIIMS-----LWEKFQTNPTITGLDTDFHNQNVVFPTTVVC-------PEAA------FDH---- 114
            ::..|     .|..|   |:.|.:..::..| :.||...||       |..:      ..|
Human   100 LLSWSSNRLLYWLSF---PSHTRVHREWSRQ-LPFPAVTVCNNNPLRFPRLSKGDLYYAGHWLGL 160

  Fly   115 ---DKTYEKVYNTLANYDEAQAQMY---TPFLRILTSLNFENVRDAKVLSQSIPQNLLDAHTIRE 173
               ::|...:.:.|...||.:.|.:   ..|...|...:||.:      |.:....|
Human   161 LLPNRTARPLVSELLRGDEPRRQWFRKLADFRLFLPPRHFEGI------SAAFMDRL-------- 211

  Fly   174 WAFEGHIDCKNVFVSCKYRDEDIPCCDH-FEPIYTEHGFCYAFNSRFKSTP-TEDVKTGAPHDL- 235
                || ..:::.:|||||.|  .|..| |..::|::|.||.|||.....| ...||.|..:.|
Human   212 ----GH-QLEDMLLSCKYRGE--LCGPHNFSSVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLE 269

  Fly   236 ----YETDKKWALFFIPNSTSRIFIFSNEEYFGSDFNAQI-DWSEPQLVE-----VRISKKNTYT 290
                .:.|:     ::|     |:..:.|..|.:....|| ..|||..::     |....:....
Human   270 IMLDIQQDE-----YLP-----IWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVA 324

  Fly   291 TDDARQLSI----GQRKCIFSDEVKLNYFPDAYTFSSCMKQCRMNKAIKLCKC-------NPPFY 344
            |.:.|...:    |:.:   |.|:.|::|| .|:.::|...|.....::.|.|       :.||.
Human   325 TQEQRLTYLPPPWGECR---SSEMGLDFFP-VYSITACRIDCETRYIVENCNCRMVHMPGDAPFC 385

  Fly   345 KPIRELSCVINIFTNLIAYILLLYLTPKANVPMCSIKDFD-CLDEFKSNITNI-KDCLQCELSCS 407
            .|.:...|.                  :..:.:.:.||.: ||.....|:|.. |:....::...
Human   386 TPEQHKECA------------------EPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSK 432

  Fly   408 KTVFNIDKLIKMSDRPESLGVLV-----EFLTWPIIRYKR--EVLFGWVDLLVSFGGIASLFLGF 465
            .:...::|....|::..|..:||     |.|.:..|..|:  ||    ..||...||...||:|.
Human   433 TSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEV----AALLGDIGGQMGLFIGA 493

  Fly   466 SLLSGVEIIYYFTLRACCMVYKNRQELYE-IEEKI-----RQEPPPKIDLKLS----LKSHNPRI 520
            |:|:.:|:..|               :|| |:||:     ::|.....|..:|    :.:|:..|
Human   494 SILTILELFDY---------------IYELIKEKLLDLLGKEEDEGSHDENVSTCDTMPNHSETI 543

  Fly   521 GDT 523
            ..|
Human   544 SHT 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk23	NP_001097011.1	ASC	34..476	CDD:279230	115/509 (23%)
ASIC2	NP_899233.1	ENaC	64..547	CDD:273304	127/564 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920