DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk23 and ppk28

DIOPT Version :9

Sequence 1:	NP_001097011.1	Gene:	ppk23 / 32731	FlyBaseID:	FBgn0030844	Length:	591	Species:	Drosophila melanogaster
Sequence 2:	NP_573169.2	Gene:	ppk28 / 32671	FlyBaseID:	FBgn0030795	Length:	606	Species:	Drosophila melanogaster

Alignment Length:	639	Identity:	151/639 - (23%)
Similarity:	236/639 - (36%)	Gaps:	204/639 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RRSLIYQTKEFFQNSTLHGVRYIAESGRPIGEKFMWFCFTSIGAVTALVIIMS------LWEKFQ 82
            :||::|    :.:||||||::||||....|.|:..:      |....||:|:|      ::.|:.
  Fly    37 KRSVVY----YLKNSTLHGLKYIAEESITIPERIFF------GLAFVLVVILSVFFISNVYVKWS 91

  Fly    83 TNPTITGLDTDFHNQ---NVVFPTTVVCPEAAFDHDKTYEKVYNTLANYDEAQAQMYTPFLRILT 144
            .:|.|  :.|....:   |:.||...:|                   |.::|.........|  |
  Fly    92 ASPII--ISTSAKQKLTSNMPFPAITIC-------------------NLNQALLSKVDRIGR--T 133

  Fly   145 SLNFENVRDAKVLSQSIPQNLLD------AHTIREWAFEGHI------DCKNVFVSCKY--RDED 195
            |.||           |:...|.|      ...|..|.:...|      .|:.:.:.|.:  |:||
  Fly   134 STNF-----------SLLMGLCDQGGDTTISYIGTWKYFKAILVDVAQPCEKMLLYCSFGSREED 187

  Fly   196 IPCCDHFEPIYTEHGFCYAFNSRFKS----TPTEDVK--TGAPHDLYE-----TDKKWAL----F 245
              |...|..|.|:.|.|..||:...|    ..::||:  |..|:..||     .:|.:|.    |
  Fly   188 --CSWLFTSILTDDGLCCNFNALHPSYLIRNYSDDVRLETAHPNTRYELIDWTPEKGYARNLPEF 250

  Fly   246 FIPNST---------SRIFIFSNEEYF---------------------GSDFNAQIDWSEPQLVE 280
            :.|.::         :.:...|..||:                     .|::...:....    |
  Fly   251 YFPRTSGGTGIRMGLTVVLNASIAEYYCTKSMSVGFKVLVHNPAELPKVSNYGFVVTAGR----E 311

  Fly   281 VRISKKNTYTTDDA----RQLSIGQRKCIFSDEVKLNYFPDAYTFSSCMKQCRMNKAIKLCKCNP 341
            .||..:..|  :||    |.:....|:|:||||..|.|:   .|:|  .|.|.:....||.
  Fly   312 ARIPIEPVY--EDALPTIRSIKKSVRRCLFSDENDLAYY---RTYS--RKNCELECEAKLL---- 365

  Fly   342 PFYKPIRELSCVINIFTNLIAYILLLYLTPKAN--VPMCSIKDFDCLD----EFKSNITNIKDCL 400
                 :||.|||             ||..|:.:  ..:|...|..|.|    |.:|::||: .|.
  Fly   366 -----LRECSCV-------------LYYLPRIDPLARVCGPNDNQCTDRVQTEIESSLTNL-SCE 411

  Fly   401 QCELSCSKTVF--NIDKLIKMSD--------RPE-----------SLGVLVEFLTWPIIR-YKRE 443
            .|...|.:..:  .:.....:||        .||           .:.:|..:....|.| ..:.
  Fly   412 NCWPGCFELTYRATLSTASIVSDPRFQAGENLPEYIFHGPYSNASEISILHFYYMTNIFRSTTKS 476

  Fly   444 VLFGWVDLLVSFGGIASLFLGFSLLSGVEIIYYFTLRACC------MVYKNRQE----LYEIEEK 498
            .:||:.:.|.:.||:..||:|||:.|.:||.:|.|:|..|      ..:|.|.|    |..|...
  Fly   477 EMFGFTEFLSNTGGLLGLFMGFSIFSVIEIFFYITVRPYCASRTLRQRHKRRLEQLSWLTPIRMP 541

  Fly   499 IR-----------QEPPPKI--DL-KLSLKSHNPRIGDTPTSAVLKVKPAEESA 538
            :|           :.|||..  || |...|...|..........|:|:|..:.|
  Fly   542 VRRALRRNRGGLLRNPPPPAYSDLQKFRGKLDKPETCKRKLWRTLQVRPVVDRA 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk23	NP_001097011.1	ASC	34..476	CDD:279230	126/541 (23%)
ppk28	NP_573169.2	ASC	43..509	CDD:279230	126/541 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920