DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk23 and Asic3

DIOPT Version :9

Sequence 1:	NP_001097011.1	Gene:	ppk23 / 32731	FlyBaseID:	FBgn0030844	Length:	591	Species:	Drosophila melanogaster
Sequence 2:	XP_038963092.1	Gene:	Asic3 / 286920	RGDID:	708578	Length:	564	Species:	Rattus norvegicus

Alignment Length:	534	Identity:	112/534 - (20%)
Similarity:	190/534 - (35%)	Gaps:	165/534 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 FFQNSTLHGVRYIAESGRPIGEKFMWFCFTSIGAVTALVIIMSLWEKFQTNPTITGLDTDFHNQN 98
            |..:.|:||:.:|...|.....:.:|        .||:::.::.: .:|....:.... :||::
  Rat    21 FASSCTMHGLGHIFGPGGLTLRRGLW--------ATAVLLSLAAF-LYQVAERVRYYG-EFHHK- 74

  Fly    99 VVFPTTVVCPEAAFDHDKTYEKVYNTLANYDEAQAQMYTPFLRILTSLNF-----------ENVR 152
                ||:   :....|..|:..|  ||.|.:..:....||     ..|::           |:..
  Rat    75 ----TTL---DERESHQLTFPAV--TLCNINPLRRSRLTP-----NDLHWAGTALLGLDPAEHAA 125

  Fly   153 DAKVLSQ-SIPQNLLDAHTI---REWAFEGHIDCKNVFVSCKYRDEDIPC-CDHFEPIYTEHGFC 212
            ..:.|.| ..|...:.:.|.   :.:|..|| ..:::.:.|:||.:  || .::|..|:|..|.|
  Rat   126 YLRALGQPPAPPGFMPSPTFDMAQLYARAGH-SLEDMLLDCRYRGQ--PCGPENFTVIFTRMGQC 187

  Fly   213 YAFNSRFKSTPTEDVKTGAPH--DLYETDKKWALFFIPNSTSRIFIFSNEEYFGSDFNAQIDWSE 275
            |.|||            || |  :|..|.|..|    .|....:.....|||...       |.:
  Rat   188 YTFNS------------GA-HGAELLTTPKGGA----GNGLEIMLDVQQEEYLPI-------WKD 228

  Fly   276 ----PQLVEVRISKKNTYTTDDARQLSIGQRKCIFSDEVKLNYFPDAYTFSSCMKQCRMNKAIKL 336
                |..|.:|:   ..::.|:...:          |::.....|...||.||.:|       :|
  Rat   229 MEETPFEVGIRV---QIHSQDEPPAI----------DQLGFGAAPGHQTFVSCQQQ-------QL 273

  Fly   337 CKCNPPF----------------------------YKPIRELSCVINIFTNLIAY---ILLLYLT 370
            ....||:                            ..|...:.|.:...:..:|.   ..::::
  Rat   274 SFLPPPWGDCNTASLDPDDFDPEPSDPLGSPRPRPSPPYSLIGCRLACESRYVARKCGCRMMHM- 337

  Fly   371 PKANVPMCSIKDF-DC----LDEFKSNITNIKDCLQCELSCSKTVF-------------NIDKLI 417
             ..|.|:||.:.: ||    ||....     ||...|...|:.|.:             :...|.
  Rat   338 -PGNSPVCSPQQYKDCASPALDAMLR-----KDTCVCPNPCATTRYAKELSMVRIPSRASARYLA 396

  Fly   418 KMSDRPES--------LGVLVEFLTWPIIRYKREVLFGWVDLLVSFGGIASLFLGFSLLSGVEII 474
            :..:|.||        |.:..|.|.:..:..|  ..:...:||...||...||:|.|||:.:||:
  Rat   397 RKYNRSESYITENVLVLDIFFEALNYEAVEQK--AAYEVSELLGDIGGQMGLFIGASLLTILEIL 459

  Fly   475 YYFTLRACCMVYKN 488
            .|.     |.|.||
  Rat   460 DYL-----CEVGKN 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk23	NP_001097011.1	ASC	34..476	CDD:279230	107/520 (21%)
Asic3	XP_038963092.1	ASC	17..547	CDD:413546	112/534 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920