Protein Alignment ppk23 and Scnn1a

DIOPT Version :9

• Sequence 1: NP_001097011.1
• Gene: ppk23 / 32731
• FlyBaseID: FBgn0030844
• Length: 591
• Species: Drosophila melanogaster
• Sequence 2: NP_113736.1
• Gene: Scnn1a / 25122
• RGDID: 3639
• Length: 699
• Species: Rattus norvegicus
• Alignment Length: 707
• Identity: 150/707 - (21%)
• Similarity: 222/707 - (31%)
• Gaps: 248/707 - (35%)

  Fly     2 PQEKRHPPESRTQRFLETLVIFRRSLIYQTKEFFQ----NSTLHG-VRYIAESGRPIGEKF---M 58
            |...|.|.|..     |.|:.|.||.    :|.||    |:|:|| :|.:......:...|   :
  Rat    61 PSAPRQPTEEE-----EALIEFHRSY----RELFQFFCNNTTIHGAIRLVCSKHNRMKTAFWAVL 116

  Fly    59 WFC-FTSIGAVTALVIIMSLWEKFQTNPTITGLDTDFHNQNVVFPTTVVC----------PEAAF 112
            |.| |..:....||     |:|::.:.|  ..|:.:.::..:|||...||          .|...
  Rat   117 WLCTFGMMYWQFAL-----LFEEYLSYP--VSLNINLNSDKLVFPAVTVCTLNPYRYTEIKEELE 174

  Fly   113 DHDKTYEKVYNTLANYDEAQAQMYT-------------------PFLRILT-------------- 144
            :.|:..|:....|..|:.:    ||                   |..|:.|
  Rat   175 ELDRITEQTLFDLYKYNSS----YTRQAGARRRSSRDLLGAFPHPLQRLRTPPPPYSGRTARSGS 235

  Fly   145 -SLNFENV----RDAKVLSQSIPQNLLD---------AHTIREWAFEGHID-------------- 181
             |:...|.    :|.|:..|...||..|         ...:|||....:|:
  Rat   236 SSVRDNNPQVDRKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLSDTSPALEE 300

  Fly   182 --CKNVFVSCKYRDEDIPC-----CDHFEPIYTEHGFCYAFNSRFKSTPTEDVKTGAPHDLYETD 239
              ..|...:|::  ...||     .....|:|   |.||.||.:..|........|..:.|..|.
  Rat   301 EALGNFIFTCRF--NQAPCNQANYSKFHHPMY---GNCYTFNDKNNSNLWMSSMPGVNNGLSLTL 360

  Fly   240 KKWALFFIP-NST---SRIFIFSNEE-YFGSD--FNAQIDWSEPQLVEVRISKKNTYTTDDARQL 297
            :.....||| .||   :|:.:...:| .|..|  ||.:..      ||..||.:....  |:...
  Rat   361 RTEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPG------VETSISMRKEAL--DSLGG 417

  Fly   298 SIGQRKCIFSDEVKLNYFPDAYTFSSCMKQCRMNKAIKLCKCNPPFYKPIRELSCVINIFTNLIA 362
            :.|......||....|.:|..||...|:..|.....||.|.|                      |
  Rat   418 NYGDCTENGSDVPVKNLYPSKYTQQVCIHSCFQENMIKKCGC----------------------A 460

  Fly   363 YILLLYLTPKANVPMCSIKDFD----CLDEFKSNITNIKDCLQCELSCSK--TVFNIDKLIKMSD 421
            ||  .|..|| .|..|..:...    |..:.:...:  .|.|.|...|.|  :|.|    .|:|
  Rat   461 YI--FYPKPK-GVEFCDYRKQSSWGYCYYKLQGAFS--LDSLGCFSKCRKPCSVIN----YKLS- 515

  Fly   422 RPESLGVLVEFLTWPIIR------------------------YKREVLF--------------GW 448
                    ..:..||.::                        .|..:.|              ..
  Rat   516 --------AGYSRWPSVKSQDWIFEMLSLQNNYTINNKRNGVAKLNIFFKELNYKTNSESPSVTM 572

  Fly   449 VDLLVSFGGIASLFLGFSLLSGV---EIIYYFTLRACCMVYKNRQELY-----------EIEEKI 499
            |.||.:.|...||:.|.|:||.|   |:|:...:....|:.:..:..|           |:....
  Rat   573 VSLLSNLGSQWSLWFGSSVLSVVEMAELIFDLLVITLLMLLRRFRSRYWSPGRGARGAREVASTP 637

  Fly   500 RQ-----------EPPPKIDLKLSLKSHNPRIGDTPTSAVLKVKPAEESAGPN--PL 543
            ..           .|||.:          |:.|.||..|:....||..:.||:  ||
  Rat   638 ASSFPSRFCPHPTSPPPSL----------PQQGMTPPLALTAPPPAYATLGPSAPPL 684

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk23	NP_001097011.1	ASC	34..476	CDD:279230	123/582 (21%)
Scnn1a	NP_113736.1	ENaC	80..677	CDD:273304	138/674 (20%)
		deg-1	88..600	CDD:273309	119/575 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820