Protein Alignment ppk23 and Scnn1g

DIOPT Version :10

• Sequence 1: NP_001097011.1
• Gene: ppk23 / 32731
• FlyBaseID: FBgn0030844
• Length: 591
• Species: Drosophila melanogaster
• Sequence 2: NP_035456.1
• Gene: Scnn1g / 20278
• MGIID: 104695
• Length: 655
• Species: Mus musculus
• Alignment Length: 655
• Identity: 128/655 - (19%)
• Similarity: 229/655 - (34%)
• Gaps: 214/655 - (32%)

  Fly    37 NSTLHGVRYIAES-GRPIGEKFMWFCFTSIGAVTALVIIMSLWE------KFQTNPTITGLDTDF 94
            |:..||.|.|..| ||.  .:.:|..||    :||:.:|  :|:      .|.|    ..:....
Mouse    35 NTNTHGCRRIVVSRGRL--RRLLWIAFT----LTAVALI--IWQCALLVFSFYT----VSVSIKV 87

  Fly    95 HNQNVVFPTTVVCPEAAFDHDKTYEKVYNTLANYD----EAQAQMY------------------- 136
            |.|.:.||...:|....:    .|..|.:.|.:.|    :|...:|
Mouse    88 HFQKLDFPAVTICNINPY----KYSAVSDLLTDLDSETKQALLSLYGVKDVLDSTPRKRREAGSM 148

  Fly   137 ------TP--FLRILTSLNF-EN----VRD----------AKVLSQSIPQNLLDAH--------- 169
                  ||  ||.::..|.| ||    .||          .|::.::  .|::..|
Mouse   149 RSTWEGTPPRFLNLIPLLVFNENEKGKARDFFTGRKRKISGKIIHKA--SNVMHVHESKKLVGFQ 211

  Fly   170 -------------------TIREWAFEGH-----------------IDCKNVFVSCKYRDEDIPC 198
                               .|:|| ::.|                 ...:.:.|:|.:   |...
Mouse   212 LCSNDTSDCATYTFSSGINAIQEW-YKLHYMNIMAQVPLEKKINMSYSAEELLVTCFF---DGMS 272

  Fly   199 CD------HFEPIYTEHGFCYAFNSRFKSTPTEDVKTGAPHD----LYETDKKWALFFIPNSTSR 253
            ||      ...|:|   |.||.||:|..:|.......|:.:.    ||..:.::..|.:.::.::
Mouse   273 CDARNFTLFHHPMY---GNCYTFNNRENATILSTSMGGSEYGLQVILYINEDEYNPFLVSSTGAK 334

  Fly   254 IFIFSNEEY-FGSDFNAQIDWSEPQLV------EVRISKKNTYTTDDARQLSIGQRKCIFSDEVK 311
            :.:....|| |..|...:|:.:....:      ..::|:..:..|:|.            ||...
Mouse   335 VLVHQQNEYPFIEDVGTEIETAMSTSIGMHLTESFKLSEPYSQCTEDG------------SDVPV 387

  Fly   312 LNYFPDAYTFSSCMKQCRMNKAIKLCKCNPPFYKPIRELSCVINIFTNLIAYILLLYLTPKANVP 376
            .|.:..||:...|:..|...|.::.|.| ..:.:|                      |.|.||
Mouse   388 TNIYNAAYSLQICLYSCFQTKMVEKCGC-AQYSQP----------------------LPPAAN-- 427

  Fly   377 MCSIKDFD----CLDE-FKSNITNIKDCLQ-CELSCSKTVFNIDKLIKMSDRPESLGVLVEFLTW 435
            .|:.:...    |..: :::.:.....|.. |:.|||...:.:...:.......|...|:..|||
Mouse   428 YCNYQQHPNWMYCYYQLYQAFVREELGCQSVCKQSCSFKEWTLTTSLAQWPSEASEKWLLNVLTW 492

  Fly   436 P-----------------IIRYK----REVL---FGWVDLLVS-FGGIASLFLGFSLLSGVEIIY 475
            .                 :|.||    |.::   ...:::|:| |||...|::..|::..:|||.
Mouse   493 DQSQQINKKLNKTDLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIE 557

  Fly   476 YFTLRACCMVYKNRQELYEIEEKIRQEPPPKIDLKLSLKSH-NPRI---GDTPT-SAVLKVKPAE 535
            .|.:....::.: ||.....:...|:..||..:...|.:.. ||.:   .|.|| ::.:::.||.
Mouse   558 VFFIDFFSIIAR-RQWQKAKDWWARRRTPPSTETPSSQQGQDNPALDTDDDLPTFTSAMRLPPAP 621

  Fly   536 ESAGP 540
            |:..|
Mouse   622 EAPVP 626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk23	NP_001097011.1	ASC	34..476	CDD:459966	112/584 (19%)
Scnn1g	NP_035456.1	ENaC	24..636	CDD:273304	128/655 (20%)
		Gating release of inhibition by proteolysis (GRIP), protease-sensitive region that is responsible for the proteolytic activation of the channel. /evidence=ECO:0000305|PubMed:15007080, ECO:0000305|PubMed:18650438	140..227		13/88 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	582..636		12/45 (27%)
		PY motif, recruits WW domain-containing proteins and is thereby required for ubiquitination and inhibition of the channel by NEDD4 and NEDD4L. /evidence=ECO:0000250|UniProtKB:P51170	629..633