Protein Alignment ppk23 and Asic1

DIOPT Version :10

• Sequence 1: NP_001097011.1
• Gene: ppk23 / 32731
• FlyBaseID: FBgn0030844
• Length: 591
• Species: Drosophila melanogaster
• Sequence 2: NP_001276720.1
• Gene: Asic1 / 11419
• MGIID: 1194915
• Length: 559
• Species: Mus musculus
• Alignment Length: 590
• Identity: 119/590 - (20%)
• Similarity: 202/590 - (34%)
• Gaps: 195/590 - (33%)

  Fly    35 FQNS-TLHGVRYIAESGRPIGEKFMWFCFTSIGAVTAL-VIIMSLWEK---FQTNPTITGLDTDF 94
            |.|| ||||..::...|.|...:.:|    ::..|.|| ..:..:.::   :.:.|.:|.|| :.
Mouse    66 FANSCTLHGASHVFVEGGPGPRQALW----AVAFVIALGAFLCQVGDRVAYYLSYPHVTLLD-EV 125

  Fly    95 HNQNVVFPTTVVCPEAAFDHDKTYEKVYNTLANYDEAQAQMYTPFLRILTSLNFENVRDAKV-LS 158
            ....:|||....|               ||  |........|...|.:...|..:...|..| |:
Mouse   126 ATTELVFPAVTFC---------------NT--NAVRLSQLSYPDLLYLAPMLGLDESDDPGVPLA 173

  Fly   159 QSIPQNLLDAHTIREWAFEGHIDCKNVFV--SCKYRDEDI---------PCCDH-FEPIYTEHGF 211
            ...|:           ||.|.....:.|.  || :|.||:         ||..| |..::|.:|.
Mouse   174 PPGPE-----------AFSGEPFNLHRFYNRSC-HRLEDMLLYCSYCGGPCGPHNFSVVFTRYGK 226

  Fly   212 CYAFNSRFKSTP-TEDVKTGAPHDL-----YETDKKWALFFIPNSTSRIFIFSNEEYFGSDFNAQ 270
            ||.|||.....| .:.:|.|..:.|     .:.|:     ::|     ::..::|..|.:....|
Mouse   227 CYTFNSGQDGRPRLKTMKGGTGNGLEIMLDIQQDE-----YLP-----VWGETDETSFEAGIKVQ 281

  Fly   271 I-DWSEPQLVEVRISKKNTYTTDDARQLSIGQ----RKCIFSDEVKLNYFP-------------- 316
            | ...||..::               ||..|.    :..:...|.:|.|.|
Mouse   282 IHSQDEPPFID---------------QLGFGVAPGFQTFVSCQEQRLIYLPSPWGTCNAVTMDSD 331

  Fly   317 --DAYTFSSCMKQCRMNKAIKLCKCNPPFYKPIRELSCVINIFTNLIAYILLLYLTPKANVPMCS 379
              |:|:.::|...|.....::.|.|.                         ::::  ..:.|.|:
Mouse   332 FFDSYSITACRIDCETRYLVENCNCR-------------------------MVHM--PGDAPYCT 369

  Fly   380 IKDF-DCLDEFKSNITNIKD---CLQCELSCSKTVFNID-KLIKMSDRPES-------------- 425
            .:.: :|.|.....:.. ||   |: ||:.|:.|.:..: .::|:..:..:
Mouse   370 PEQYKECADPALDFLVE-KDQEYCV-CEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYI 432

  Fly   426 ------LGVLVEFLTWPIIRYKREVLFGWVDLLVSFGGIASLFLGFSLLSGVEIIYYFTLRACCM 484
                  |.:..|.|.:..|..|:  .:....||...||...||:|.|:|:.:|:..|
Mouse   433 GENILVLDIFFEVLNYETIEQKK--AYEIAGLLGDIGGQMGLFIGASILTVLELFDY-------- 487

  Fly   485 VYKNRQELYEI------------EEKIRQEPPPKIDLKL-SLKSHNP-------RIGDTPTSAVL 529
                   .||:            :|..|......:.|.| .:|.|||       ..|.|..:.:|
Mouse   488 -------AYEVIKHRLCRRGKCQKEAKRNSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANIL 545

  Fly   530 KVKPA 534
            ...||
Mouse   546 PHHPA 550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk23	NP_001097011.1	ASC	34..476	CDD:459966	103/510 (20%)
Asic1	NP_001276720.1	ENaC	63..541	CDD:273304	116/579 (20%)