Protein Alignment ppk23 and Asic2

DIOPT Version :10

• Sequence 1: NP_001097011.1
• Gene: ppk23 / 32731
• FlyBaseID: FBgn0030844
• Length: 591
• Species: Drosophila melanogaster
• Sequence 2: XP_006532059.1
• Gene: Asic2 / 11418
• MGIID: 1100867
• Length: 596
• Species: Mus musculus
• Alignment Length: 628
• Identity: 134/628 - (21%)
• Similarity: 226/628 - (35%)
• Gaps: 194/628 - (30%)

  Fly     6 RHPPESRT-QRFLETLVIFRRSLIYQTKEFFQNSTLHGVRYIAESGRPIGEKF----MW---FCF 62
            |.|...|: .|.|:...:.||.     :.....:.|||:|::.......|..|    :|   ||
Mouse    36 RQPGGDRSGDRELQGPGVARRG-----RPSLSRTKLHGLRHMCAGRTAAGGSFQRRALWVLAFC- 94

  Fly    63 TSIGAVTALVIIMS-----LWEKFQTNPTITGLDTDFHNQNVVFPTTVVC-------PEAA---- 111
            ||:|    |::..|     .|..|   |:.|.:..::..| :.||...||       |..:
Mouse    95 TSLG----LLLSWSSNRLLYWLSF---PSHTRVHREWSRQ-LPFPAVTVCNNNPLRFPRLSKGDL 151

  Fly   112 --FDH-------DKTYEKVYNTLANYDEAQAQMY---TPFLRILTSLNFENVRDAKVLSQSIPQN 164
              ..|       ::|...:.:.|...||.:.|.:   ..|...|...:||.:      |.:....
Mouse   152 YYAGHWLGLLLPNRTARPLVSELLRGDEPRRQWFRKLADFRLFLPPRHFEGI------SAAFMDR 210

  Fly   165 LLDAHTIREWAFEGHIDCKNVFVSCKYRDE--------DIPC----------------------- 198
            |            || ..:::.:|||||.|        .:.|
Mouse   211 L------------GH-QLEDMLLSCKYRGELCGPHNFSSVSCPPREPALSDPALPRSPEALRWAP 262

  Fly   199 -CDHFEPIYTEHGFCYAFNSRFKSTP-TEDVKTGAPHDL-----YETDKKWALFFIPNSTSRIFI 256
             ..|..|::|::|.||.|||.....| ...||.|..:.|     .:.|:     ::|     |:.
Mouse   263 GTGHQAPVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDE-----YLP-----IWG 317

  Fly   257 FSNEEYFGSDFNAQI-DWSEPQLVE-----VRISKKNTYTTDDARQLSI----GQRKCIFSDEVK 311
            .:.|..|.:....|| ..|||..::     |....:....|.:.|...:    |:.:   |.|:.
Mouse   318 ETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECR---SSEMG 379

  Fly   312 LNYFPDAYTFSSCMKQCRMNKAIKLCKC-------NPPFYKPIRELSCVINIFTNLIAYILLLYL 369
            |::|| .|:.::|...|.....::.|.|       :.||..|.:...|.
Mouse   380 LDFFP-VYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECA---------------- 427

  Fly   370 TPKANVPMCSIKDFD-CLDEFKSNITNI-KDCLQCELSCSKTVFNIDKLIKMSDRPESLGVLV-- 430
              :..:.:.:.||.: ||.....|:|.. |:....::....:...::|....|::..|..:||
Mouse   428 --EPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLD 490

  Fly   431 ---EFLTWPIIRYKR--EVLFGWVDLLVSFGGIASLFLGFSLLSGVEIIYYFTLRACCMVYKNRQ 490
               |.|.:..|..|:  ||    ..||...||...||:|.|:|:.:|:..|
Mouse   491 IFFEALNYETIEQKKAYEV----AALLGDIGGQMGLFIGASILTILELFDY-------------- 537

  Fly   491 ELYE-IEEKI-----RQEPPPKIDLKLS----LKSHNPRIGDT 523
             :|| |:||:     ::|.....|..:|    :.:|:..|..|
Mouse   538 -IYELIKEKLLDLLGKEEEEGSHDENMSTCDTMPNHSETISHT 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk23	NP_001097011.1	ASC	34..476	CDD:459966	115/540 (21%)
Asic2	XP_006532059.1	ENaC	64..590	CDD:273304	127/595 (21%)