Protein Alignment ppk23 and asic2

DIOPT Version :10

• Sequence 1: NP_001097011.1
• Gene: ppk23 / 32731
• FlyBaseID: FBgn0030844
• Length: 591
• Species: Drosophila melanogaster
• Sequence 2: XP_004918663.1
• Gene: asic2 / 100492214
• XenbaseID: XB-GENE-6033380
• Length: 541
• Species: Xenopus tropicalis
• Alignment Length: 575
• Identity: 122/575 - (21%)
• Similarity: 211/575 - (36%)
• Gaps: 179/575 - (31%)

  Fly    36 QNSTLHGVRYIAESGRPIGEKFMWFC--FTSIGAVTALVIIMS-------LWEKFQTNPTITGLD 91
            |:..|||::||.........:..||.  |||:|      ..:|       .|..|   |:.|.:.
 Frog    46 QHIKLHGLKYICSPKLAFRHRTFWFLAFFTSLG------FFLSWSSNRLLYWLSF---PSHTRVQ 101

  Fly    92 TDFHNQNVVFPTTVVCPEAAFDHDKTYEKVYNTLANYDEAQAQMYTPFLRILTSLNFENVRDAKV 156
            .:: ::.:.||....|..             |.:..:..:::.:|  |......|.|.|.....:
 Frog   102 LEW-SKELAFPAVTFCNN-------------NPVRFHRLSKSDLY--FAGYWLGLLFANRTARPM 150

  Fly   157 LSQSIPQNLLDAHTIREWAFE-------------------------GHIDCKNVFVSCKYRDEDI 196
            |::.:|::.      |:| |:                         || ..:::.:|||||.|
 Frog   151 LAELLPEDR------RKW-FQKLADFRLFLPPRNFDGISVGFMDRLGH-QLEDMLLSCKYRGE-- 205

  Fly   197 PCCDH-FEPIYTEHGFCYAFNSRFKSTPT-EDVKTGAPHDL-----YETDKKWALFFIPNSTSRI 254
            .|..| |..::|.:|.||.|||.....|. ..||.||.:.|     .:.|:     ::|     |
 Frog   206 ACGPHNFSTVFTRYGKCYMFNSGQDGRPVLTTVKGGAGNGLEIMLDIQQDE-----YLP-----I 260

  Fly   255 FIFSNEEYFGSDFNAQI-DWSEPQLVE-----VRISKKNTYTTDDAR--QLSIGQRKCIFSDEVK 311
            :..:.|..|.:....|| ..|||..::     |....:....|.:.|  .|......|.|| |:.
 Frog   261 WGDTEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPSPWGACRFS-ELG 324

  Fly   312 LNYFPDAYTFSSCMKQCRMNKAIKLCKCNPPFYKPIRELSCVINIFTNLIAYILLLYLTPKANVP 376
            .::|| .|:.|:|...|.....::.|.|.                         ::::  ..:.|
 Frog   325 SDFFP-VYSISACRIDCETRYIVENCGCK-------------------------MVHM--PGDAP 361

  Fly   377 MCSIKDFDCLDEFKSNITNIKD---CLQCELSCSKTVFNID-KLIKMSDRPES------------ 425
            .|:.:.:....|...::...||   |: |.:.|:.|.:|.: .::|:..:..:
 Frog   362 FCTPEQYKECAEPALDLLAEKDGGNCV-CTIPCNVTRYNKELSMVKIPSKTSAKYLEKKFNKSEK 425

  Fly   426 --------LGVLVEFLTWPIIRYKR--EVLFGWVDLLVSFGGIASLFLGFSLLSGVEIIYYFTLR 480
                    |.|..|.|.:..|..::  ||    ..||...||...||:|.|:|:.:|:..|
 Frog   426 YILDNILVLDVFFEALNYETIEQRKAYEV----AGLLGDIGGQMGLFIGASILTILELFDY---- 482

  Fly   481 ACCMVYKNRQELYE-IEEKI-------RQEPPPKIDLKL--SLKSHNPRIGDTPT 525
                       :|| |:||:       .:|.....||..  ::.:|:..|..|.|
 Frog   483 -----------IYELIKEKLLDLLGRENEEGGRTEDLSTCDTMPNHSDSISHTVT 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk23	NP_001097011.1	ASC	34..476	CDD:459966	109/514 (21%)
asic2	XP_004918663.1	ENaC	49..497	CDD:273304	114/541 (21%)