DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG43658 and ARHGEF17

DIOPT Version :10

Sequence 1:NP_001259643.1 Gene:CG43658 / 32729 FlyBaseID:FBgn0263706 Length:2263 Species:Drosophila melanogaster
Sequence 2:NP_055601.2 Gene:ARHGEF17 / 9828 HGNCID:21726 Length:2063 Species:Homo sapiens


Alignment Length:2264 Identity:458/2264 - (20%)
Similarity:741/2264 - (32%) Gaps:733/2264 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    91 GGV----AKQCLQFPPPPDYPP-----PITGGGGSPVNTTPGRRQQLPRYPDPDPDAIE-ICNES 145
            |||    |::..:.|....:|.     .:.||.||   ..|....:.|..|.||..|.| ...||
Human   104 GGVLPAAAEEAAEGPARGAWPSVTEMRKLFGGPGS---RRPSADSESPGTPSPDGAAWEPPARES 165

  Fly   146 ATLETSP----YHLKQLAARH----SKTLGRNLGHQPHHHHT------VHLHHDYSYAYYEPGAA 196
            ....|.|    :.|..|.:..    .:|.||....|......      :|..|.:|    :|.|.
Human   166 RQPPTPPPRTCFPLAGLRSARPLTGPETEGRLRRPQQQQERAQRPADGLHSWHIFS----QPQAG 226

  Fly   197 MRHSNVPGAVSSGGGGGGGGAGRVSSVVDTSSSSSPTAEPPPNSIRALLSKGKKNKQLVSPATLQ 261
            .|.|                          .||||..|..|.:..||..|..::.:   .|..|.
Human   227 ARAS--------------------------CSSSSIAASYPVSRSRAASSSEEEEE---GPPQLP 262

  Fly   262 SYQT-RYHKLTTKSGMGQSENFYEEINAAALQTSSGHHLRSTVGSHSAGSLNQTLVEEELRRVQN 325
            ..|: .||.       |.|....::.:.     ..||......|.....|    |::::.|...:
Human   263 GAQSPAYHG-------GHSSGSDDDRDG-----EGGHRWGGRPGLRPGSS----LLDQDCRPDSD 311

  Fly   326 RHHKILGELNLS------VEAMLMPESPPKSIDQQPLGSGSGGSGGAEATP-PQ----------- 372
                   .||||      |.....|.:.|::..::  |....|||.....| ||           
Human   312 -------GLNLSSMNSAGVSGSPEPPTSPRAPREE--GLREWGSGSPPCVPGPQEGLRPMSDSVG 367

  Fly   373 ----------PSVSVTAASGQPPTILARLTSASADNICDSGGEAGKRTKTAPGCPGGGVEQLLTT 427
                      ||...:.|..:..:..:...:...|::..|.|..|.....:|....|  |.||.:
Human   368 GAFRVAKVSFPSYLASPAGSRGSSRYSSTETLKDDDLWSSRGSGGWGVYRSPSFGAG--EGLLRS 430

  Fly   428 TCGDLDSGFSGSSGASYIGSLRLSKTQHIKCARQTPTVGTQSCR--SFQRA----ATVYDEAGMS 486
            .......|..|:|.|...|.....|::..| :...|.:.:::..  ||.|:    ..|....|.|
Human   431 QARTRAKGPGGTSRALRDGGFEPEKSRQRK-SLSNPDIASETLTLLSFLRSDLSELRVRKPGGSS 494

  Fly   487 GGGGQSGSSFLTRASCGRRI--LSCARIRAAEDPGPNHRIAGGNGIQTVQTTATESKARSF-WSR 548
            |..|.:........|.|..:  |....|.|...||....:.        ..|||..:|:|| .|.
Human   495 GDRGSNPLDGRDSPSAGGPVGQLEPIPIPAPASPGTRPTLK--------DLTATLRRAKSFTCSE 551

  Fly   549 KGW-RKLPGFSTSTSSINDTGLSDEHKLNSGSWEDTLDEPHHHHAHHSHHQQHLHQHHSHLSQRH 612
            |.. |:||..|...||.::..|:     ..|:.||.|.               |.....::.:..
Human   552 KPMARRLPRTSALKSSSSELLLT-----GPGAEEDPLP---------------LIVQDQYVQEAR 596

  Fly   613 Q-----QQQQQQQQLQQTSFIGSPPSSASITTAQLHSAFSRRIAEQRERDQRDQRDQREAVG--- 669
            |     |:...||.....:..|||..:..:|..|       |..|:....:....|  |.:|   
Human   597 QVFEKIQRMGAQQDDGSDAPPGSPDWAGDVTRGQ-------RSQEELSGPESSLTD--EGIGADP 652

  Fly   670 -------CTAAT------IAGGSFSAN----------GGQAAV--------------------GV 691
                   |...|      ::..|...|          ||.|.|                    |.
Human   653 EPPVAAFCGLGTTGMWRPLSSSSAQTNHHGPGTEDSLGGWALVSPETPPTPGALRRRRKVPPSGS 717

  Fly   692 GVGSSSSCGSSSE--RDTKSPCRERDRNLERDRDRERDKNDDL--------GEEEVLTEEEQTSS 746
            | ||..|.|.:.|  |....|..:|.|....:.......:.:|        |.......:|..:|
Human   718 G-GSELSNGEAGEAYRSLSDPIPQRHRAATSEEPTGFSVDSNLLGSLSPKTGLPATSAMDEGLTS 781

  Fly   747 SVSSLSAGNQRNSQLRSTFNKAKQ------HLSFD-------KWRTAATGSATGSASGPGSSATD 798
            ..|..|.|::.:...:.......|      .:..|       |.::.:..|..|..:|||.....
Human   782 GHSDWSVGSEESKGYQEVIQSIVQGPGTLGRVVDDRIAGKAPKKKSLSDPSRRGELAGPGFEGPG 846

  Fly   799 SNNAASNMIMRRASACTMPSSG-----------GGGGAGVGSSQREEATTPGESPGGRLSRWFS- 851
            ...      :|.......|||.           ...||....:|.|.|......|.....|.|. 
Human   847 GEP------IREVEPMLPPSSSEPILVEQRAEPEEPGATRSRAQSERALPEALPPPATAHRNFHL 905

  Fly   852 ------------IRRG-------SSHQ---YDVGGRD-----------GRH-------STASSFD 876
                        ||||       ||||   .|.|.:|           .||       :|.....
Human   906 DPKLADILSPRLIRRGSKKRPARSSHQELRRDEGSQDQTGSLSRARPSSRHVRHASVPATFMPIV 970

  Fly   877 TPDSGSGNSPKNGSNAVAGTGGAG--------SQGVALDAASPQKLANLGASKMMPGVPESEDDE 933
            .|:..:...|     .||.....|        .|..:|:..:.|.:.||.:.::...||      
Human   971 VPEPPTSVGP-----PVAVPEPIGFPTRAHPTLQAPSLEDVTKQYMLNLHSGEVPAPVP------ 1024

  Fly   934 ATANRFDVDLMMTPGSRANGTARTAHNRLIVPMLPPAPAG--LSQQQL-KRRHIVAAIVHSENSY 995
                   ||:...| ..|..:|.........|...|.||.  .|:.|: .|:|:...::.:|.||
Human  1025 -------VDMPCLP-LAAPPSAEAKPPEAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSY 1081

  Fly   996 VATLQRLVNDYKKPLEECSPPVL-NPVKIATLFHCLPDILHSHKLFRISLAECVRNWDRDEKIGD 1059
            |.:|:.|:..|.:||::....|| :|..:..:|..:|::|..|:.|...:..|::.|...:|:|.
Human  1082 VESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGA 1146

  Fly  1060 CFVSAFGKPQLLEIYSGFINNFSAAMELAKMEEKRKSALADFFKVKQISAHDRLSFFGLMVKPVQ 1124
            ..|.:|.|..|:.|||.:|:||..|.:..::.::.:.|...|.:.......::.:...||:||||
Human  1147 LLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSDLMIKPVQ 1211

  Fly  1125 RFPQFILFLQDLLKYTPQGHHDRMSLQLALSQLELLAELLNESKREAEQYQ----AFKEMLGHIS 1185
            |.|::.|.::||||:||:.|.|...|..|...::.:||.:|:..|.||:.:    ..:|:..||.
Human  1212 RIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIE 1276

  Fly  1186 GTFNARSLSLSSVSVSDSAGGHRP-RYLLREDNVTHMEFNQAGFIVKCKQRRLLLLNDKVICVSV 1249
            |..:.::                | |..||::.|..::     .|...|.|.|.|..|.::|.::
Human  1277 GMEDLQA----------------PLRRFLRQEMVIEVK-----AIGGKKDRSLFLFTDLIVCTTL 1320

  Fly  1250 APKQ-------------SHDFGATEKLTFKWMFPVNDVEIVDNSTSATLSRILTAGLNRGGSLKS 1301
            ..|.             :.......|....|..|:.|.:|:..::.||         ||      
Human  1321 KRKSGSLRRSSMSLYTAASVIDTASKYKMLWKLPLEDADIIKGASQAT---------NR------ 1370

  Fly  1302 NGSSGANGSPYANSTLPGHGGGVSGFSGFGDPHSSPAAQLTNGADNLCSEMSTLMYDYEVISRIQ 1366
                                                        :|:...:|.|..|...:.::.
Human  1371 --------------------------------------------ENIQKAISRLDEDLTTLGQMS 1391

  Fly  1367 DLVSSLKGSYKELNANTTRNVLNLIQGSIQRKDEEMAWVDSCCLQLIGRHKSGKEETFTFQTQTP 1431
            .|..||...::.|:     :.|..:..::.|...|                   ::...:....|
Human  1392 KLSESLGFPHQSLD-----DALRDLSAAMHRDLSE-------------------KQALCYALSFP 1432

  Fly  1432 AVKKEWITELRLAQLALDPNNSPAWERGGSHPQPAHHHPHHHPLQHPHAGAGDPRQTQEQLQLQE 1496
            ..|.|..                     .:.|:....:....|  ||     |.|...|| ...|
Human  1433 PTKLELC---------------------ATRPEGTDSYIFEFP--HP-----DARLGFEQ-AFDE 1468

  Fly  1497 AVQQKQSRKM---PLFVKAMPVYKSQHQTEVRCGCYYSIANDTKQSGNARRRHKQLN-------Y 1551
            |.::..|.|.   |.|:||:|:.|:      |.|..:|.|..|            ||       .
Human  1469 AKRKLASSKSCLDPEFLKAIPIMKT------RSGMQFSCAAPT------------LNSCPEPSPE 1515

  Fly  1552 LWMCSSDGTSSHITVL----------------------------------------------AQH 1570
            :|:|:|||....:.:|                                              |..
Human  1516 VWVCNSDGYVGQVCLLSLRAEPDVEACIAVCSARILCIGAVPGLQPRCHREPPPSLRSPPETAPE 1580

  Fly  1571 P------------QQAGNLREAGAFDLFETQV--SALEFVKGLDQ-------------------- 1601
            |            ::|..|.|.|........:  |.||...||.:                    
Human  1581 PAGPELDVEAAADEEAATLAEPGPQPCLHISIAGSGLEMTPGLGEGDPRPELVPFDSDSDDESSP 1645

  Fly  1602 -----LKSR-------------------------------DEPASL------------------- 1611
                 |:|:                               .||..|                   
Human  1646 SPSGTLQSQASRSTISSSFGNEETPSSKEATAETTSSEEEQEPGFLPLSGSFGPGGPCGTSPMDG 1710

  Fly  1612 ---------------LGDL-----------VWLGTDSRKILIYSA-------RNPEQEEQLGSYS 1643
                           |.||           |||||:...:.:|.:       ||..:.:...|  
Human  1711 RALRRSSHGSFTRGSLEDLLSVDPEAYQSSVWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAAS-- 1773

  Fly  1644 VPGAVQRILYHFDAVYVALSGATVLIFRRGNDGVWQLRDPQTIRLGDTDLVVPSLLPINMCIYAS 1708
                |..|||..:.|:|:|:...:::::|.....|..::.:::.||.....:..::.:...::..
Human  1774 ----VTCILYLNNQVFVSLANGELVVYQREAGHFWDPQNFKSVTLGTQGSPITKMVSVGGRLWCG 1834

  Fly  1709 CGNRVYVMNALNGEIQRSFEVQHGATQQVNLMAHSGIGLWISLKNSTMLCLYHTETFKHLQDINI 1773
            |.|||.|::....:::..|.|...:::.|..|..|.:|:|::||.|..:||||.:||:.|.::::
Human  1835 CQNRVLVLSPDTLQLEHMFYVGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDV 1899

  Fly  1774 ASSVLRHDGKKEQPLNN---SSVYVTALMACKGLLWVGTNVGIAVTIP-------LPRLEGVPII 1828
            ...|.|.....:..:..   :.:.:|||:.|:.||||||:.|:.:|:|       .||   .|:.
Human  1900 TPPVHRMLAGSDAIIRQHKAACLRITALLVCEELLWVGTSAGVVLTMPTSPGTVSCPR---APLS 1961

  Fly  1829 SGGINMSCHAHFGPITFLLPL-IPKVY----PAYKPPTVGAAPLVPSMGDDLQLPAID------- 1881
            ..|:.   ..|.|.:.||..: :|..:    |...||        |..|.: :||:::       
Human  1962 PTGLG---QGHTGHVRFLAAVQLPDGFNLLCPTPPPP--------PDTGPE-KLPSLEHRDSPWH 2014

  Fly  1882 -----ADPKIQELDDGAVVLRRDLAKEEMSSSNPGADSTASSPRSSKLDKQNSL 1930
                 |.||:..:..|.       ..|:...|:.|..|:.:..|.   |..|.|
Human  2015 RGPAPARPKMLVISGGD-------GYEDFRLSSGGGSSSETVGRD---DSTNHL 2058

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG43658NP_001259643.1 RhoGEF 984..1153 CDD:459876 52/169 (31%)
PH_19 1210..1376 CDD:465965 28/178 (16%)
WD40_2 1551..>1846 CDD:465964 88/472 (19%)
ARHGEF17NP_055601.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 22..365 70/321 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 380..466 17/88 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 485..581 28/108 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 602..958 72/371 (19%)
PHA03247 <829..1054 CDD:223021 50/249 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1034..1060 6/25 (24%)
RhoGEF 1067..1252 CDD:238091 57/184 (31%)
PH_19 1281..1402 CDD:465965 29/200 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1564..1584 2/19 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1616..1719 9/102 (9%)
WD40_2 1724..>1978 CDD:465964 68/265 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1991..2020 6/37 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2036..2055 5/21 (24%)

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