Protein Alignment CG43658 and arhgef10la

DIOPT Version :10

• Sequence 1: NP_001259643.1
• Gene: CG43658 / 32729
• FlyBaseID: FBgn0263706
• Length: 2263
• Species: Drosophila melanogaster
• Sequence 2: XP_009304376.2
• Gene: arhgef10la / 799435
• ZFINID: ZDB-GENE-120814-1
• Length: 1342
• Species: Danio rerio
• Alignment Length: 1532
• Identity: 405/1532 - (26%)
• Similarity: 642/1532 - (41%)
• Gaps: 342/1532 - (22%)

  Fly   608 LSQRHQQQQQQQQQLQQTSFIGSPP------SSASITTAQLHSAFSRRIAEQRERDQRDQRDQ-- 664
            ||...:..|::|..|.|.:...||.      |...::||..|.....::.::.:|::...:|:
Zfish    50 LSSALEATQKKQSDLFQDASTSSPAGCTNTHSEKPMSTASSHQQLGEKVEDKEQREKSRCKDEIS 114

  Fly   665 -----REAVGCTAATIAGGSFSANGGQAAVGVGVGSSSSCGSSSERDTKSPCRERDRNLERDRDR 724
                 .|...||..|.:....|....||..           ||....|..|......|...|..|
Zfish   115 KTDAGDETSTCTVWTCSSDLESTPDKQADY-----------SSQATMTSYPVECSTINNATDSKR 168

  Fly   725 ERDKNDDLGEEEVLTEEEQTSSSVSSLSAGNQRNSQLRSTFNKAKQHLSFDKWRTAATGSATGSA 789
            ::...|....|::..||:.|.:.|..     ||::      ...|.:...:.:|.:.:.:|.|:.
Zfish   169 DQASTDSTAPEDLNEEEDHTCTVVKI-----QRDT------CTIKTNAGTEDFRHSPSQNAEGNV 222

  Fly   790 SGPGSSAT-------------DSNNAASNMI---MRRASACTMPSSGGGGGAGVGSSQREEATTP 838
            |......|             |.::..:::|   :::......|::|..........::.::..|
Zfish   223 STESEHQTAGPEVIYDDVPSEDLSSGEADLIYEDVQKEEGLQGPNNGWSSSEFESYDEQSDSERP 287

  Fly   839 GE----SPG--------GRLSRWFSIRRGSSHQYDVGGRDGRHSTASSFDTPDSGSGNSPKNGSN 891
            ..    ||.        .|..:..::|.|..||.....|..|..|.
Zfish   288 PTRSKLSPDVRRLRDRYTRTKQELAMRLGGKHQVHQLMRAARSGTK------------------- 333

  Fly   892 AVAGTGGAGSQGVALDAASPQKLANLGASKMMPGVPESEDDEATANRFDVDLMMTPGSRANGTAR 956
                           |.....|:|.:.....:.....|:|.|......||  |::.......
Zfish   334 ---------------DGLEKTKIAVMRRVSFLHKKDHSDDTEDDTGYLDV--MVSEAKHPPA--- 378

  Fly   957 TAHNRLIVPMLPPAPAGLSQQQLKRRHIVAAIVHSENSYVATLQRLVNDYKKPLEECSPPVLNPV 1021
                     .|.|.|.|||.||:.||||:::||.||.||:.:|:|::.:|::||.|..|.:|:..
Zfish   379 ---------QLGPMPDGLSSQQIVRRHILSSIVQSERSYLDSLKRILQEYQRPLMEAEPRILSVR 434

  Fly  1022 KIATLFHCLPDILHSHKLFRISLAECVRNWDRDEKIGDCFVSAFGKPQLLEIYSGFINNFSAAME 1086
            ||..:|..|.:|...|.:|:|:||..|..||..|||||.||::|.|..:|::||.::|||:.||.
Zfish   435 KIRPIFFRLREITQCHSMFQIALASRVAEWDSCEKIGDLFVASFSKSMVLDVYSDYVNNFTNAMA 499

  Fly  1087 LAKMEEKRKSALADFFKVKQISAHDRLSFFGLMVKPVQRFPQFILFLQDLLKYTPQGHHDRMSLQ 1151
            |.|.....|.|..:|.|.||.|:.||::.:||||||:||||||||.|||:||.||.||.||:.||
Zfish   500 LIKKACLSKPAFLEFLKRKQASSVDRITLYGLMVKPIQRFPQFILLLQDMLKNTPTGHVDRLPLQ 564

  Fly  1152 LALSQLELLAELLNESKREAEQYQAFKEMLGHISGTFNARSLS--LSSVSVSDSAGGHRPRYLLR 1214
            |||::||.|||.|||.||.|:|....:::...:|.    ||||  |:|...|          |:.
Zfish   565 LALTELETLAEKLNEQKRVADQITETQQLARCVSD----RSLSKLLNSEQSS----------LIL 615

  Fly  1215 EDNVTHMEFNQAGFIVKCKQRRLLLLNDKVICVSVAPKQSHDFGAT----EKLTFKWMFPVNDVE 1275
            .:.:....:.:.|.::|.|:|::.|..|.:||.::..|...|..:.    .|.|.||..|:..|:
Zfish   616 CETLIETVYGERGQVLKSKERKVFLFGDVLICANINVKGPPDISSLVPVGPKYTLKWSAPLQQVQ 680

  Fly  1276 IVDNSTSATLSRILTAGLNRGGSLKSNGSSGANGSPYANSTLPGHGGGVSGFSGFGDPHSSPAAQ 1340
            :|:....|:.|:   ..|.:.||:|..|||...||
Zfish   681 VVEVGQEASQSK---DTLYQLGSVKRPGSSFGQGS------------------------------ 712

  Fly  1341 LTNGADNLCSEMSTLMYDYEVISRIQDLVSSLKGSYKELNANTTRNVLNLIQGSIQRKDEEMAWV 1405
            :..|...|..|:..|.:|..|:.::..||.:|:|:|:.||....::....:|..|:.|::::...
Zfish   713 IILGPPRLYHELQELQHDLSVVEQVTLLVGTLQGTYQNLNTTVAQDWCLALQRLIRIKEDQIQNA 777

  Fly  1406 DSC--CLQLIGR-HKSGKEETFT--FQTQTPAVKKEWITELRLAQLALDPNNSPAW---ERGGSH 1462
            :.|  .||:.|| .|||:..:||  |.|.:|..|..|.....||::||...|:|.|   |..|..
Zfish   778 NKCRLRLQVPGRPDKSGRPVSFTVVFNTPSPVSKISWANRFHLAKIALRDENTPGWFFAEDDGKT 842

  Fly  1463 PQPAHHHPHHHPLQHPHAGAGDPRQTQEQLQLQEAVQQKQSRKMPLFVKAMPVYKSQH--QTEVR 1525
            ..     |...||                          .:.:||:|....|.:|.:.  ...|:
Zfish   843 KA-----PFWCPL--------------------------LACRMPVFTSKAPEWKLEAALHNPVQ 876

  Fly  1526 CGCY-YSIANDTKQSGNARRRHKQLNYLWMCS-SDGTSSHITVLAQH---PQQAGNLREAGAFDL 1585
            |... :|.|:.:...|          |||:.| :|.|...:.:.:.:   |:...:| :.||
Zfish   877 CALLGFSAASTSLPQG----------YLWVASGADSTQGQVDIFSLNRPTPRPVKSL-QMGA--- 927

  Fly  1586 FETQVSALEFVKGLDQLKSRDEPASL-----LGDLVWLGTDSRKILIYSARNPEQEEQLGSYSVP 1645
               ||..||:|.  :...|.|...||     :|:.:.:|.|...||:|.:.:...:..:..::..
Zfish   928 ---QVRCLEYVP--EPSPSEDAETSLHSSAEVGNTICVGLDDGSILVYGSMDSAAQCLVTLHNPE 987

  Fly  1646 GAVQRILYHFDAV-YVALSGATVLIFRRGN-DGVWQLRDPQTIRLGDTDLVVPSLLPINMCIYAS 1708
            |.....|.|.:.| :..|....::::.|.: .|:|.....:.:.:|...  :.:||.:...::||
Zfish   988 GCPVLCLKHCNNVLFAGLRDGKLMVYERHHRGGLWNQDTSRKVTIGSHP--IRTLLALENSVWAS 1050

  Fly  1709 CGNRVYVMNALNGEIQRSFEVQHGATQQVNLMAHSGIGLWISLKNSTMLCLYHTETFKHLQDINI 1773
            |.|.|.|:|..:...|| |||.......|..|..:|.|:|::....:.:.|:||||.:|||:|||
Zfish  1051 CANTVTVVNGSSLSTQR-FEVHQDPMVSVAHMVRAGGGVWMAFSEGSSIRLFHTETLEHLQEINI 1114

  Fly  1774 AS-SVLRHDGKKEQPLNNSSVYVTALMACKGLLWVGTNVGIAVTIPLPRLEGVPIISGGINMSCH 1837
            :: |...:..:|       |:.||:|:.|:|||||||..||.:|:|:|:|||:|.|:|...||.:
Zfish  1115 STPSSFYNPSQK-------SMRVTSLLICQGLLWVGTAQGIIITLPVPKLEGIPKITGKGMMSFN 1172

  Fly  1838 AHFGPITFLLPLIPKVYPAYKPPTVGAAPLVPSMGDDLQLPAIDADPKIQELDDGAVVLRRDLAK 1902
            ||.||:.||:.|...:.|                  ||                    |:||...
Zfish  1173 AHCGPVDFLVALSSTLSP------------------DL--------------------LKRDSVI 1199

  Fly  1903 EEMSSSNPGADSTASSPRSSKLDKQNSLDQ-SFTAKIRASLANSPAFHRKRFRDDPNRMSKTLPR 1966
            |       |.||.......|....|.||.| |.:.::...........:.|.|
Zfish  1200 E-------GHDSGCGVEDRSDSSSQESLQQHSVSTQVDGKGKGRGVLLQYRLR------------ 1245

  Fly  1967 GLGAAAAGSGAGGASAAGSG-TASGNTSQHGEHGICDVYGLYGKLIFVKEDYDAEEGNQGNLMDM 2030
                  :.||..|......| .||.::.:..||.:.|     |.:..:.:|.|
Zfish  1246 ------STSGLPGRPLTARGDEASDSSLESLEHSMED-----GSIYELSDDPD------------ 1287

  Fly  2031 MY--------EGMRRSDPELAAI--PGKVCTLDRRLR 2057
            |:        ||:||......|:  .||..   ||||
Zfish  1288 MWVRGRPCEREGVRRDRVTSVAVISGGKGF---RRLR 1321

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43658	NP_001259643.1	RhoGEF	984..1153	CDD:459876	83/168 (49%)
		PH_19	1210..1376	CDD:465965	39/169 (23%)
		WD40_2	1551..>1846	CDD:465964	95/306 (31%)
arhgef10la	XP_009304376.2	None