Protein Alignment CG43658 and Arhgef10l

DIOPT Version :10

• Sequence 1: NP_001259643.1
• Gene: CG43658 / 32729
• FlyBaseID: FBgn0263706
• Length: 2263
• Species: Drosophila melanogaster
• Sequence 2: NP_001277732.1
• Gene: Arhgef10l / 72754
• MGIID: 1920004
• Length: 1280
• Species: Mus musculus
• Alignment Length: 1535
• Identity: 392/1535 - (25%)
• Similarity: 608/1535 - (39%)
• Gaps: 414/1535 - (26%)

  Fly   686 QAAVGVGVGSSSSCGSSSERDTKSPCRERDRNLERDRDR--ERDKNDDLGEEEVLTEEEQTSSSV 748
            |.|:|..:..|:. |.|.|             :|.|...  |.|.:|         |||.|||.:
Mouse     9 QPAIGAPLAPSAP-GPSPE-------------VEEDSGEAFEFDDSD---------EEEDTSSGL 50

  Fly   749 SSLSAGNQRNSQLRSTFNKAKQHLSFDKWRTAATGSATGSASGPGSSATDSNNAASNMIMRRASA 813
            .......:|:::        ...:.||    ...||....|:.|                .:..|
Mouse    51 VVPGLAPERDTE--------PSLICFD----TVPGSDLDPAAAP----------------PQTEA 87

  Fly   814 CTMPSSGGGGGAGVG----------SSQREEATT-------------PGESPGGRLSRWFSIRRG 855
            .|:.|:|...||.:.          ||:|.:..|             |.|||.....   ...||
Mouse    88 PTVVSNGDAVGAAISGVRRSSWKRKSSRRIDRFTFPALEEDVIYDDVPCESPDAHQP---GAERG 149

  Fly   856 SSHQYDVGGRDGRHST------ASSFD--TPDSGSGNSPKNGSNAVAGTGGAGSQGVALDAASPQ 912
            ..:: ||........|      :|.|:  :.|||....|:                     |.|.
Mouse   150 LVYE-DVHRAGAPRETEDLGWSSSEFESYSEDSGEETKPE---------------------AEPT 192

  Fly   913 KLANLGASKMMPGVPESEDDEATANRFDV-----------------DLMMT-------PGSRANG 953
            |.......|:.|.:...::......| |:                 |..||       .|:| :|
Mouse   193 KHRGSFQPKLSPDLTRLKERYVRTKR-DILALRVGGRDMQELKLKCDCKMTQLMKAAKSGTR-DG 255

  Fly   954 TART----------AHNRLIV----------------------PMLPPAPAGLSQQQLKRRHIVA 986
            ..:|          .|.:.::                      |.|.|.|.|||.||:.||||:.
Mouse   256 LEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVGVTDIKPPAPELGPMPDGLSPQQVVRRHILG 320

  Fly   987 AIVHSENSYVATLQRLVNDYKKPLEECSPPVLNPVKIATLFHCLPDILHSHKLFRISLAECVRNW 1051
            :||.||.|||.:|:|::.||:.||.|..|..|:..|...:|..:.:|||.|.:|:|:|:..|..|
Mouse   321 SIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEW 385

  Fly  1052 DRDEKIGDCFVSAFGKPQLLEIYSGFINNFSAAMELAKMEEKRKSALADFFKVKQISAHDRLSFF 1116
            |..|||||.||::|.|..:|::||.::|||:.||.:.|.....|.|..:|.|.:|:.:.||::.:
Mouse   386 DSTEKIGDLFVASFSKSMVLDVYSDYVNNFTNAMSIIKKACLTKPAFLEFLKRRQVCSTDRVTLY 450

  Fly  1117 GLMVKPVQRFPQFILFLQDLLKYTPQGHHDRMSLQLALSQLELLAELLNESKREAEQYQAFKEML 1181
            |||||||||||||||.|||:||.||:||.||:||||||::||.|||.|||.||.|:|....:::.
Mouse   451 GLMVKPVQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLT 515

  Fly  1182 GHISGTFNARSLSLSSVSVSDSAGGHRPRYLLREDNVTHMEFNQAGFIVKCKQRRLLLLNDKVIC 1246
            ..:|...:...|..|.           .|.||..:.:|...:...|.::|.|:||:.||||.::|
Mouse   516 KSVSDRSSLNKLLTSG-----------QRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVC 569

  Fly  1247 VSVAPKQSHDFGATE---------KLTFKWMFPVNDVEIVDNSTSATLSRILTAGLNRGGSLKSN 1302
            .::..|.|:..|..|         |...||...:..|::|:
Mouse   570 ANINFKPSNHRGQLEISSLVPLGPKYVVKWNTALPQVQVVE------------------------ 610

  Fly  1303 GSSGANGSPY-ANSTLPGHGGGVSGFSGFGDPHSSPAAQLTN----GADNLCSEMSTLMYDYEVI 1362
              .|.:|..| .::.|..|.|.         ..::.|.|..|    |...|..|:..|..|..|:
Mouse   611 --VGQDGGTYDKDNLLIQHAGA---------KKATAAGQAQNKVYLGPPRLFQELQDLQKDLAVV 664

  Fly  1363 SRIQDLVSSLKGSYKELNANTTRNVLNLIQGSIQRKDEEMAWVDSCCLQLI--GR-HKSGKEETF 1424
            .:|..|:|:|.|:|:.||....::....:|..::.|:||:...:.|.|:|:  |: .|||:..:|
Mouse   665 EQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPGKPDKSGRPISF 729

  Fly  1425 --TFQTQTPAVKKEWITELRLAQLALDPNNSPAWERGGSHPQPAHHHPHHHPLQHPHAGAGDPRQ 1487
              .|.|..|..|..|:..|.||::.|...|.|.|
Mouse   730 MVVFITPNPLSKISWVNRLHLAKIGLREENQPGW------------------------------- 763

  Fly  1488 TQEQLQLQEAVQQKQSRKMPLFVKAMPVYKSQHQTEVRCGCYYSIANDTKQSGNARRRHKQLNYL 1552
                |...|..:.|.....|:....:|.:.|:..:....|..:|..|......:|........||
Mouse   764 ----LCPDEDKKSKAPFWCPILACCVPAFSSRTLSLQLGGLVHSPVNSPLLGFSAVSTSLPQGYL 824

  Fly  1553 WM-CSSDGTSSHITVLA-QHPQQAGNLREAGAFDLFETQVSALEFV-------KGLDQLKSRDEP 1608
            |: ...:|....:.:.: ..|..    |...:|.: ...|..:|::       :|.::.::..:|
Mouse   825 WVGGGQEGAGGQVEIFSLNRPSP----RTVKSFPV-AAPVLCIEYIPDPEEEAEGAEESRAATDP 884

  Fly  1609 ASLLGDLVWLGTDSRKILIYSARNPEQEEQLGSYSVPGAVQRILYHFDAVYV--ALSGATVLIF- 1670
            :..:...|.||.....||:|.:.: ...:.|.:...||....:.......|:  .|...|:..:
Mouse   885 SVTVHPTVCLGLQDGSILLYGSVD-TGTQCLATCKSPGPQPVLCLRHSPFYLLAGLQDGTLAAYP 948

  Fly  1671 RRGNDGVWQLRD-PQTIRLGDTDLVVPSLLPINMCIYASCGNRVYVMNALNGEIQRSFEVQHGAT 1734
            |...|..|.|.. |..|.:|...  :.:||.:....:||||.||.|::|...:.|:|||......
Mouse   949 RTSGDIPWDLESPPMCITVGPGP--IRTLLSLEDAAWASCGPRVTVLDAATLQTQQSFEAHQDEA 1011

  Fly  1735 QQVNLMAHSGIGLWISLKNSTMLCLYHTETFKHLQDINIAS-SVLRHDGKKEQPLNNSSVYVTAL 1798
            ..|..|..:|.|:|::..:.:.:.|:||||.:|||:||||: :.....|:|.       :.||:|
Mouse  1012 VSVTHMVKAGSGVWMAFSSGSSIRLFHTETLEHLQEINIATRTTFLLPGQKH-------LCVTSL 1069

  Fly  1799 MACKGLLWVGTNVGIAVTIPLPRLEGVPIISGGINMSCHAHFGPITFLLPLIPKVYPAYKPPTVG 1863
            :.|:|||||||:.|:.|.:|:|||||:|.|:|...:|.:.|.||:.||              .|.
Mouse  1070 LICQGLLWVGTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFL--------------AVA 1120

  Fly  1864 AAPLVPSMGDDLQLPAIDAD-PKIQELDDGAVVLRRDLAKEEMSSSNPGADSTASSPRSSKLDKQ 1927
            .:.|.|   |.|:....:|: |:.:|          |....:...:.||.||..:...:.|
Mouse  1121 MSILAP---DILRSDQEEAEGPQAEE----------DKPDGQAHETVPGPDSHTARELTRK---- 1168

  Fly  1928 NSLDQSFTAKIRASLANSPAFHRKRFRDDPNRMSKTLPRGLGAAAAGSGAGGASAAGSGTASGNT 1992
                :....:.|.                  |.:..||..|           .|......|.|:.
Mouse  1169 ----KGILLQYRL------------------RSTAHLPGPL-----------LSVREPAPADGSA 1200

  Fly  1993 SQHGEHGICDVYGLYGKLIFVKEDYDAEEGNQGNLMDMMYEGMRRSDPELAAIPGKVCTLDRRLR 2057
            .:|.|                      |:|:       :||  ...||::
Mouse  1201 LEHSE----------------------EDGS-------IYE--MADDPDV--------------- 1219

  Fly  2058 MKASRPRSLDLSNWSVDSKSSSLYTSSGSEESMGIRHFGG 2097
            ...|||.:.|.....:    .|:...||.:   |.|||||
Mouse  1220 WVRSRPCARDAHRKEI----CSVAIISGGQ---GYRHFGG 1252

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43658	NP_001259643.1	RhoGEF	984..1153	CDD:459876	83/168 (49%)
		PH_19	1210..1376	CDD:465965	43/179 (24%)
		WD40_2	1551..>1846	CDD:465964	89/308 (29%)
Arhgef10l	NP_001277732.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..94		28/135 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	161..202		10/61 (16%)
		RhoGEF	315..499	CDD:238091	94/183 (51%)
		PH_19	524..679	CDD:465965	45/200 (23%)
		WD40_2	787..1278	CDD:465964	139/598 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1133..1163		8/39 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1186..1207		6/53 (11%)