DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG43658 and Arhgef10l

DIOPT Version :9

Sequence 1:NP_001259643.1 Gene:CG43658 / 32729 FlyBaseID:FBgn0263706 Length:2263 Species:Drosophila melanogaster
Sequence 2:NP_001277732.1 Gene:Arhgef10l / 72754 MGIID:1920004 Length:1280 Species:Mus musculus


Alignment Length:1535 Identity:392/1535 - (25%)
Similarity:608/1535 - (39%) Gaps:414/1535 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   686 QAAVGVGVGSSSSCGSSSERDTKSPCRERDRNLERDRDR--ERDKNDDLGEEEVLTEEEQTSSSV 748
            |.|:|..:..|:. |.|.|             :|.|...  |.|.:|         |||.|||.:
Mouse     9 QPAIGAPLAPSAP-GPSPE-------------VEEDSGEAFEFDDSD---------EEEDTSSGL 50

  Fly   749 SSLSAGNQRNSQLRSTFNKAKQHLSFDKWRTAATGSATGSASGPGSSATDSNNAASNMIMRRASA 813
            .......:|:::        ...:.||    ...||....|:.|                .:..|
Mouse    51 VVPGLAPERDTE--------PSLICFD----TVPGSDLDPAAAP----------------PQTEA 87

  Fly   814 CTMPSSGGGGGAGVG----------SSQREEATT-------------PGESPGGRLSRWFSIRRG 855
            .|:.|:|...||.:.          ||:|.:..|             |.|||.....   ...||
Mouse    88 PTVVSNGDAVGAAISGVRRSSWKRKSSRRIDRFTFPALEEDVIYDDVPCESPDAHQP---GAERG 149

  Fly   856 SSHQYDVGGRDGRHST------ASSFD--TPDSGSGNSPKNGSNAVAGTGGAGSQGVALDAASPQ 912
            ..:: ||........|      :|.|:  :.|||....|:                     |.|.
Mouse   150 LVYE-DVHRAGAPRETEDLGWSSSEFESYSEDSGEETKPE---------------------AEPT 192

  Fly   913 KLANLGASKMMPGVPESEDDEATANRFDV-----------------DLMMT-------PGSRANG 953
            |.......|:.|.:...::......| |:                 |..||       .|:| :|
Mouse   193 KHRGSFQPKLSPDLTRLKERYVRTKR-DILALRVGGRDMQELKLKCDCKMTQLMKAAKSGTR-DG 255

  Fly   954 TART----------AHNRLIV----------------------PMLPPAPAGLSQQQLKRRHIVA 986
            ..:|          .|.:.::                      |.|.|.|.|||.||:.||||:.
Mouse   256 LEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVGVTDIKPPAPELGPMPDGLSPQQVVRRHILG 320

  Fly   987 AIVHSENSYVATLQRLVNDYKKPLEECSPPVLNPVKIATLFHCLPDILHSHKLFRISLAECVRNW 1051
            :||.||.|||.:|:|::.||:.||.|..|..|:..|...:|..:.:|||.|.:|:|:|:..|..|
Mouse   321 SIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEW 385

  Fly  1052 DRDEKIGDCFVSAFGKPQLLEIYSGFINNFSAAMELAKMEEKRKSALADFFKVKQISAHDRLSFF 1116
            |..|||||.||::|.|..:|::||.::|||:.||.:.|.....|.|..:|.|.:|:.:.||::.:
Mouse   386 DSTEKIGDLFVASFSKSMVLDVYSDYVNNFTNAMSIIKKACLTKPAFLEFLKRRQVCSTDRVTLY 450

  Fly  1117 GLMVKPVQRFPQFILFLQDLLKYTPQGHHDRMSLQLALSQLELLAELLNESKREAEQYQAFKEML 1181
            |||||||||||||||.|||:||.||:||.||:||||||::||.|||.|||.||.|:|....:::.
Mouse   451 GLMVKPVQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLT 515

  Fly  1182 GHISGTFNARSLSLSSVSVSDSAGGHRPRYLLREDNVTHMEFNQAGFIVKCKQRRLLLLNDKVIC 1246
            ..:|...:...|..|.           .|.||..:.:|...:...|.::|.|:||:.||||.::|
Mouse   516 KSVSDRSSLNKLLTSG-----------QRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVC 569

  Fly  1247 VSVAPKQSHDFGATE---------KLTFKWMFPVNDVEIVDNSTSATLSRILTAGLNRGGSLKSN 1302
            .::..|.|:..|..|         |...||...:..|::|:                        
Mouse   570 ANINFKPSNHRGQLEISSLVPLGPKYVVKWNTALPQVQVVE------------------------ 610

  Fly  1303 GSSGANGSPY-ANSTLPGHGGGVSGFSGFGDPHSSPAAQLTN----GADNLCSEMSTLMYDYEVI 1362
              .|.:|..| .::.|..|.|.         ..::.|.|..|    |...|..|:..|..|..|:
Mouse   611 --VGQDGGTYDKDNLLIQHAGA---------KKATAAGQAQNKVYLGPPRLFQELQDLQKDLAVV 664

  Fly  1363 SRIQDLVSSLKGSYKELNANTTRNVLNLIQGSIQRKDEEMAWVDSCCLQLI--GR-HKSGKEETF 1424
            .:|..|:|:|.|:|:.||....::....:|..::.|:||:...:.|.|:|:  |: .|||:..:|
Mouse   665 EQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPGKPDKSGRPISF 729

  Fly  1425 --TFQTQTPAVKKEWITELRLAQLALDPNNSPAWERGGSHPQPAHHHPHHHPLQHPHAGAGDPRQ 1487
              .|.|..|..|..|:..|.||::.|...|.|.|                               
Mouse   730 MVVFITPNPLSKISWVNRLHLAKIGLREENQPGW------------------------------- 763

  Fly  1488 TQEQLQLQEAVQQKQSRKMPLFVKAMPVYKSQHQTEVRCGCYYSIANDTKQSGNARRRHKQLNYL 1552
                |...|..:.|.....|:....:|.:.|:..:....|..:|..|......:|........||
Mouse   764 ----LCPDEDKKSKAPFWCPILACCVPAFSSRTLSLQLGGLVHSPVNSPLLGFSAVSTSLPQGYL 824

  Fly  1553 WM-CSSDGTSSHITVLA-QHPQQAGNLREAGAFDLFETQVSALEFV-------KGLDQLKSRDEP 1608
            |: ...:|....:.:.: ..|..    |...:|.: ...|..:|::       :|.::.::..:|
Mouse   825 WVGGGQEGAGGQVEIFSLNRPSP----RTVKSFPV-AAPVLCIEYIPDPEEEAEGAEESRAATDP 884

  Fly  1609 ASLLGDLVWLGTDSRKILIYSARNPEQEEQLGSYSVPGAVQRILYHFDAVYV--ALSGATVLIF- 1670
            :..:...|.||.....||:|.:.: ...:.|.:...||....:.......|:  .|...|:..: 
Mouse   885 SVTVHPTVCLGLQDGSILLYGSVD-TGTQCLATCKSPGPQPVLCLRHSPFYLLAGLQDGTLAAYP 948

  Fly  1671 RRGNDGVWQLRD-PQTIRLGDTDLVVPSLLPINMCIYASCGNRVYVMNALNGEIQRSFEVQHGAT 1734
            |...|..|.|.. |..|.:|...  :.:||.:....:||||.||.|::|...:.|:|||......
Mouse   949 RTSGDIPWDLESPPMCITVGPGP--IRTLLSLEDAAWASCGPRVTVLDAATLQTQQSFEAHQDEA 1011

  Fly  1735 QQVNLMAHSGIGLWISLKNSTMLCLYHTETFKHLQDINIAS-SVLRHDGKKEQPLNNSSVYVTAL 1798
            ..|..|..:|.|:|::..:.:.:.|:||||.:|||:||||: :.....|:|.       :.||:|
Mouse  1012 VSVTHMVKAGSGVWMAFSSGSSIRLFHTETLEHLQEINIATRTTFLLPGQKH-------LCVTSL 1069

  Fly  1799 MACKGLLWVGTNVGIAVTIPLPRLEGVPIISGGINMSCHAHFGPITFLLPLIPKVYPAYKPPTVG 1863
            :.|:|||||||:.|:.|.:|:|||||:|.|:|...:|.:.|.||:.||              .|.
Mouse  1070 LICQGLLWVGTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFL--------------AVA 1120

  Fly  1864 AAPLVPSMGDDLQLPAIDAD-PKIQELDDGAVVLRRDLAKEEMSSSNPGADSTASSPRSSKLDKQ 1927
            .:.|.|   |.|:....:|: |:.:|          |....:...:.||.||..:...:.|    
Mouse  1121 MSILAP---DILRSDQEEAEGPQAEE----------DKPDGQAHETVPGPDSHTARELTRK---- 1168

  Fly  1928 NSLDQSFTAKIRASLANSPAFHRKRFRDDPNRMSKTLPRGLGAAAAGSGAGGASAAGSGTASGNT 1992
                :....:.|.                  |.:..||..|           .|......|.|:.
Mouse  1169 ----KGILLQYRL------------------RSTAHLPGPL-----------LSVREPAPADGSA 1200

  Fly  1993 SQHGEHGICDVYGLYGKLIFVKEDYDAEEGNQGNLMDMMYEGMRRSDPELAAIPGKVCTLDRRLR 2057
            .:|.|                      |:|:       :||  ...||::               
Mouse  1201 LEHSE----------------------EDGS-------IYE--MADDPDV--------------- 1219

  Fly  2058 MKASRPRSLDLSNWSVDSKSSSLYTSSGSEESMGIRHFGG 2097
            ...|||.:.|.....:    .|:...||.:   |.|||||
Mouse  1220 WVRSRPCARDAHRKEI----CSVAIISGGQ---GYRHFGG 1252

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG43658NP_001259643.1 RhoGEF 984..1153 CDD:279015 83/168 (49%)
Arhgef10lNP_001277732.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..94 28/135 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 161..202 10/61 (16%)
RhoGEF 315..499 CDD:238091 94/183 (51%)
PH_19 524..679 CDD:408827 45/200 (23%)
WD40_2 787..1278 CDD:408826 139/598 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1133..1163 8/39 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1186..1207 6/53 (11%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167837983
Domainoid 1 1.000 239 1.000 Domainoid score I2266
eggNOG 1 0.900 - - E1_KOG3522
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002580
OrthoInspector 1 1.000 - - otm43407
orthoMCL 1 0.900 - - OOG6_106477
Panther 1 1.100 - - LDO PTHR12877
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5001
SonicParanoid 1 1.000 - - X2754
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
109.770

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