Protein Alignment CG43658 and Arhgef10l

DIOPT Version :10

• Sequence 1: NP_001259643.1
• Gene: CG43658 / 32729
• FlyBaseID: FBgn0263706
• Length: 2263
• Species: Drosophila melanogaster
• Sequence 2: XP_038967250.1
• Gene: Arhgef10l / 684811
• RGDID: 1585585
• Length: 1275
• Species: Rattus norvegicus
• Alignment Length: 1503
• Identity: 379/1503 - (25%)
• Similarity: 600/1503 - (39%)
• Gaps: 423/1503 - (28%)

  Fly   725 ERDKNDDLGEEEVLTEEEQTSSSVSSLSAGNQRNSQLRSTFNKAKQHLSFDKWRTAATGSATGSA 789
            |.|.:||         ||.|::.:.......:|:::        ...:.||   |..:.....:|
  Rat    36 EFDDSDD---------EEDTNTGLVVPGLAPERDTE--------PSLICFD---TVPSSDLDPAA 80

  Fly   790 SGPGSSATDSNNAASNMIMRRASACTMPSSGGGGGAGVG----------SSQREEATT------- 837
            :.|                 :..|.|:.|:|...||.:.          ||:|.:..|
  Rat    81 APP-----------------QTEAPTVVSNGDAVGAALSGVRHSSWKRKSSRRIDRFTFPALEED 128

  Fly   838 ------PGES-----PGGRLSRWFS--IRRGSSHQ-YDVGGRDGRHSTASSFD--TPDSGSGNSP 886
                  |.||     ||...|..:.  .|.|:..: .|:|.      ::|.|:  :.|||....|
  Rat   129 VIYDDVPCESPDAHQPGAERSLLYEDVHRAGAPREAEDLGW------SSSEFESYSEDSGEETKP 187

  Fly   887 KNGSNAVAGTGGAGSQGVALDAASPQKLANLGASKMMPGVPESEDDEATANRFDV---------- 941
            :                     |.|.|.......|:.|.:...::......| |:
  Rat   188 E---------------------AEPTKHRGSFQPKLSPDLTRLKERYVRTKR-DILALRVGGRDM 230

  Fly   942 -------DLMMTPGSRA--NGT------ARTAHNRLI---------------------------- 963
                   |..||...:|  :||      .|.|..|.:
  Rat   231 QELKLKCDCKMTQLMKAAKSGTRDGLEKTRMAVMRKVSFLHRKDTLGDSEEEDMGLLEVGVTDIK 295

  Fly   964 --VPMLPPAPAGLSQQQLKRRHIVAAIVHSENSYVATLQRLVNDYKKPLEECSPPVLNPVKIATL 1026
              .|.|.|.|.|||.||:.||||:.:||.||.|||.:|:|::.||:.||.|..|..|:..|...:
  Rat   296 PPAPELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQMV 360

  Fly  1027 FHCLPDILHSHKLFRISLAECVRNWDRDEKIGDCFVSAFGKPQLLEIYSGFINNFSAAMELAKME 1091
            |..:.:|||.|.:|:|:|:..|..||..|||||.||::|.|..:|::||.::|||:.||.:.|..
  Rat   361 FFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTNAMTIIKKA 425

  Fly  1092 EKRKSALADFFKVKQISAHDRLSFFGLMVKPVQRFPQFILFLQDLLKYTPQGHHDRMSLQLALSQ 1156
            ...|.|..:|.|.:|:.:.||::.:|||||||||||||||.|||:||.||:||.||:||||||::
  Rat   426 CLTKPAFLEFLKRRQVCSTDRVTLYGLMVKPVQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTE 490

  Fly  1157 LELLAELLNESKREAEQYQAFKEMLGHISGTFNARSLSLSSVSVSDSAGGHRPRYLLREDNVTHM 1221
            ||.|||.|||.||.|:|....:::...:|...:...|..|.           .|.||..:.:|..
  Rat   491 LETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSG-----------QRQLLLCETLTET 544

  Fly  1222 EFNQAGFIVKCKQRRLLLLNDKVICVSVAPKQSHDFGAT----EKLTFKWMFPVNDVEIVDNSTS 1282
            .:...|.::|.|:||:.||||.::|.::..|...:..:.    .|...||...:..|::|:
  Rat   545 VYGDRGQLIKSKERRVFLLNDMLVCANINFKGQLEISSLVPLGPKYVVKWNTALPQVQVVE---- 605

  Fly  1283 ATLSRILTAGLNRGGSLKSNGSSGANGSPY-ANSTLPGHGGGVSGFSGFGDPHSSPAAQLTN--- 1343
                                  .|.:|..| .::.|..|.|.         ..::.|.|..|
  Rat   606 ----------------------VGQDGGAYDKDNLLIQHAGA---------KKATAAGQAQNKVY 639

  Fly  1344 -GADNLCSEMSTLMYDYEVISRIQDLVSSLKGSYKELNANTTRNVLNLIQGSIQRKDEEMAWVDS 1407
             |...|..|:..|..|..|:.:|..|:|:|.|:|:.||....::....:|..::.|:||:...:.
  Rat   640 LGPPRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANK 704

  Fly  1408 CCLQLI--GR-HKSGKEETF--TFQTQTPAVKKEWITELRLAQLALDPNNSPAWERGGSHPQPAH 1467
            |.|:|:  |: .|||:..:|  .|.|..|..|..|:..|.||::.|...|.|.|
  Rat   705 CRLRLLLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGW----------- 758

  Fly  1468 HHPHHHPLQHPHAGAGDPRQTQEQLQLQEAVQQKQSRKMPLFVKAMPVYKSQHQTEVRCGCYYSI 1532
                                    |...|..:.|.....|:....:|.:.|:..:....|..:|.
  Rat   759 ------------------------LCPDEDKKSKAPFWCPILACCVPAFSSRALSLQLGGLVHSP 799

  Fly  1533 ANDTKQSGNARRRHKQLNYLWM-CSSDGTSSHITVLA-QHPQQAGNLREAGAFDLFETQVSALEF 1595
            .|......:|........|||: ...:|....:.:.: ..|..    |...:|.| ...|..:|:
  Rat   800 VNSPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVEIFSLNRPSP----RTVKSFPL-SAPVLCIEY 859

  Fly  1596 V-------KGLDQLKSRDEPASLLGDLVWLGTDSRKILIYSARNPEQEEQLGSYSVPGAVQRILY 1653
            :       :|.::.::..:|:..:...|.||.....||:|.:.: ...:.|.:...||....:..
  Rat   860 IPDPEEEAEGAEESRATTDPSVTVHPTVCLGLQDGSILLYGSVD-TGTQCLATCKSPGPQPVLCL 923

  Fly  1654 HFDAVYV--ALSGATVLIFRRGNDGV-WQLRDPQ---TIRLGDTDLVVPSLLPINMCIYASCGNR 1712
            .....|:  .|...|:..:.|.:..: |.|..|.   |:..|.    :.:||.:....:||||.|
  Rat   924 RHGPFYLLAGLQDGTLAAYPRTSGEIPWDLESPPVCLTVGPGP----IRTLLSLEDAAWASCGAR 984

  Fly  1713 VYVMNALNGEIQRSFEVQHGATQQVNLMAHSGIGLWISLKNSTMLCLYHTETFKHLQDINIAS-S 1776
            |.|::|...:.|:|||........|..|..:|.|:|::..:.:.:.|:||||.:|||:||||: :
  Rat   985 VTVLDAATLQTQQSFEAHQDEAVSVTHMVKAGSGVWMAFSSGSSIRLFHTETLEHLQEINIATRT 1049

  Fly  1777 VLRHDGKKEQPLNNSSVYVTALMACKGLLWVGTNVGIAVTIPLPRLEGVPIISGGINMSCHAHFG 1841
            .....|:|.       :.||:|:.|:|||||||:.|:.|.:|:|||||:|.|:|...:|.:.|.|
  Rat  1050 TFLLPGQKH-------LCVTSLLICQGLLWVGTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCG 1107

  Fly  1842 PITFLLPLIPKVYPAYKPPTVGAAPLVPSMGDDLQLPAIDADPKIQELDDGAVVLRRDLAKEEMS 1906
            |:.||              .|..:.|.|.                        :||.|  :||
  Rat  1108 PVAFL--------------AVAMSILAPD------------------------ILRSD--QEE-- 1130

  Fly  1907 SSNPGADSTASSPRSSKLDKQNSLDQSFTAKIRASLANSPAFHRKRFRDDPN-RMSKTLPRGLGA 1970
                     |..|::.:                               |.|: :..:|:|
  Rat  1131 ---------AEGPQAEE-------------------------------DKPDGQAHETVP----- 1150

  Fly  1971 AAAGSGAGGASAAGSGTASGNTSQHG---EHGICDVYGLYGKLIFVKE---------DYDAEEGN 2023
                       |..|.||...|.:.|   ::.:.....|.|.|:.|:|         ::..|:|:
  Rat  1151 -----------APDSHTARELTRKKGILLQYRLRSTAHLPGPLLSVREPAPADGSALEHSEEDGS 1204

  Fly  2024 QGNLMDMMYEGMRRSDPELAAIPGKVCTLDRRLRMKASRPRSLDLSNWSVDSKSSSLYTSSGSEE 2088
                   :||  ...||::               ...|||.:.|.....:    .|:...||.:
  Rat  1205 -------IYE--MADDPDV---------------WVRSRPCARDAHRKEI----CSVAIISGGQ- 1240

  Fly  2089 SMGIRHFG 2096
              |.||||
  Rat  1241 --GYRHFG 1246

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43658	NP_001259643.1	RhoGEF	984..1153	CDD:459876	83/168 (49%)
		PH_19	1210..1376	CDD:465965	40/174 (23%)
		WD40_2	1551..>1846	CDD:465964	89/310 (29%)
Arhgef10l	XP_038967250.1	RhoGEF	315..499	CDD:238091	94/183 (51%)
		PH_19	524..674	CDD:465965	42/195 (22%)
		WD40_2	782..1273	CDD:465964	139/611 (23%)