Protein Alignment CG43658 and arhgef10lb

DIOPT Version :9

• Sequence 1: NP_001259643.1
• Gene: CG43658 / 32729
• FlyBaseID: FBgn0263706
• Length: 2263
• Species: Drosophila melanogaster
• Sequence 2: XP_009295163.1
• Gene: arhgef10lb / 567649
• ZFINID: ZDB-GENE-090313-222
• Length: 1369
• Species: Danio rerio
• Alignment Length: 1559
• Identity: 399/1559 - (25%)
• Similarity: 656/1559 - (42%)
• Gaps: 382/1559 - (24%)

  Fly   605 HSHLSQRHQQQQQQQQQLQQTSFIGSPPSSASITTAQLHSAFSRRI-----AEQRERDQRDQRDQ 664
            |..|:..|....:.....|...|:|||         ::|.|.|:|.     :|..|.::|.:
Zfish    12 HLLLTHNHPAAMETVCMRQSLKFLGSP---------KIHLAGSKRFSYFCWSEGVEDNKRHE--- 64

  Fly   665 REAVGCTAATIAGGSFSANGGQAAVGVGVGSSSSCGSSSERDTKSPCRERDRNLERDRDRERDKN 729
                                   ::..||             |:.|..|.:.:.:.:...|:.:.
Zfish    65 -----------------------SMVTGV-------------TQKPQEEEEEDEDDEETGEKFEF 93

  Fly   730 DDLGEEEVLTEEEQTSSSVSSLSAGNQRNSQLRSTFNKAKQHLSFDKWRTAATGSATGSASGPGS 794
            ||..:|:...|:::  |....:.|....:|.:.:.:.::.:|:.... :.|..|   |:.:|
Zfish    94 DDSEDEKNAVEDKE--SGTPHVEAELSGSSDVNALYCQSMKHVMHSN-QPAVNG---GTPAG--- 149

  Fly   795 SATDSNNAAS------NMIMRRASACTMPSSGGGGGAGVGSSQREEAT----------TPGESPG 843
              .:..|..:      :|:.|:        |..|....:.....||.|          .|..|
Zfish   150 --VEEQNMPTHPHTHPDMVARQ--------SPDGSSVSIEPRAAEEQTPILKRNIIYEAPVHS-- 202

  Fly   844 GRLSRWFSIRRGSSHQYDVGGRDGRHSTASSFDTP---DSGSGNSP------------------- 886
               ..|||:    ..:..:....|:....|:.|:|   :..:..:|
Zfish   203 ---REWFSV----VSELTLRLHKGKAVPESNGDSPPEQEKVNSTAPVRSEVVYDDVPCENITPPD 260

  Fly   887 -----------KNGSNAVAGTGGAGSQGVALDAASPQKLANLGASKMMPGVPE------------ 928
                       ::|.:.:...|...|:..:.|..|..:......:|:.|.|..
Zfish   261 VVDDVIYEEVQRSGESGLIDNGWGSSEFESYDEQSDNETKQPTRNKISPDVRRLKQRCVQTRREL 325

  Fly   929 -----SEDDEATANRFDVDLMMTPGSRANGT------ARTAHNRLI------------------- 963
                 :.|.......:|:.:.....:..|||      .:.|..|.:
Zfish   326 AMRLGARDVGQLKQNYDIKVQQLMKAARNGTKDGLEKTKIAMMRKVSFLSKKECTDDTEDDTGYL 390

  Fly   964 ----------VPMLPPAPAGLSQQQLKRRHIVAAIVHSENSYVATLQRLVNDYKKPLEECSPPVL 1018
                      .|.|.|.|.|||.||:.||||:.:|:.||.||:.:|:|::.:|||||.|..|.:|
Zfish   391 DVTVSELKHPPPQLSPMPEGLSSQQVVRRHILGSIIQSERSYLDSLKRILLEYKKPLMEAEPRIL 455

  Fly  1019 NPVKIATLFHCLPDILHSHKLFRISLAECVRNWDRDEKIGDCFVSAFGKPQLLEIYSGFINNFSA 1083
            :..||..:|:.|.:||..|.:|:|:||..|..||..|||||.||::|.|..:|::||.::|||:.
Zfish   456 SLKKIQPIFYRLKEILQCHSMFQIALASRVAEWDNTEKIGDLFVASFSKSMVLDVYSDYVNNFTN 520

  Fly  1084 AMELAKMEEKRKSALADFFKVKQISAHDRLSFFGLMVKPVQRFPQFILFLQDLLKYTPQGHHDRM 1148
            ||.|.|.....|.|..:|.|.||.::.||::.:||||||:||||||||.|||:||.|..||.||:
Zfish   521 AMALIKKACMSKPAFLEFLKKKQATSIDRITLYGLMVKPIQRFPQFILLLQDMLKNTSVGHQDRL 585

  Fly  1149 SLQLALSQLELLAELLNESKREAEQYQAFKEMLGHISGTFNARSLSLSSVSV---SDSAGGHRPR 1210
            .|||||::||.|||.|||.||.|||....:::         |||:|..|:|.   ||.      :
Zfish   586 PLQLALTELETLAEKLNEQKRLAEQLAEIQQL---------ARSISDRSLSKQLNSDQ------K 635

  Fly  1211 YLLREDNVTHMEFNQAGFIVKCKQRRLLLLNDKVICVSVAPKQSHDFGAT----EKLTFKWMFPV 1271
            .|:..:.:....:.:.|.::|.|:|::.||||.:||.::..|...|..:.    .|...||..|:
Zfish   636 QLILSETLIETVYGEKGQVLKSKERKVFLLNDMLICANINVKGPPDISSLVPIGPKYAVKWTAPL 700

  Fly  1272 NDVEIVD--NSTSATLSRILTAGLNRGGSLKSNGSSGANGSPYANSTLPGHGGGVSGFSGFGDPH 1334
            ..|::|:  ..|......||....||  .|.|
Zfish   701 PQVQVVEVGQETPQRKESILQQSSNR--RLSS--------------------------------- 730

  Fly  1335 SSPAAQLTNGADNLCSEMSTLMYDYEVISRIQDLVSSLKGSYKELNANTTRNVLNLIQGSIQRKD 1399
            |:|..:|..|...|..|:..|.:|..|:..:..||.:|:|||:.||....::....:|..|:.|:
Zfish   731 SNPQGKLFLGPPRLYQELQELQHDLTVVEEVTLLVGTLQGSYQNLNTTVGQDWCMALQRLIRIKE 795

  Fly  1400 EEMAWVDSCCLQLI--GR-HKSGKEETFT--FQTQTPAVKKEWITELRLAQLALDPNNSPAWERG 1459
            :|:...:.|.|:|:  |: .|||:..:||  |.|.:|..|..|:..|.||::||...|.|.|
Zfish   796 DEIQCANKCRLRLMVPGKPDKSGRPVSFTVVFSTPSPISKISWVNRLHLAKIALREENLPGW--- 857

  Fly  1460 GSHPQPAHHHPHHHPLQHPHAGAGDPRQTQEQLQLQEAVQQKQSRKMPLFVKAMPVYKSQHQ--- 1521
                                            :.:::..:.|.....||....:||:..:.|
Zfish   858 --------------------------------VCVEDDEKTKPPFWCPLLACRVPVFTPKVQDLK 890

  Fly  1522 ------TEVRCGCY-YSIANDTKQSGNARRRHKQLNYLWMCSSDGTSSH--ITVLA-QHPQQAGN 1576
                  ..|.|... :|.|:.:...|          |||: :|.|..||  :.:.: ..|..
Zfish   891 LQAALYNPVHCALLGFSAASTSLPQG----------YLWV-ASRGDDSHGQVEIFSLNRPTP--- 941

  Fly  1577 LREAGAFDLFETQVSALEFV----KGLDQLKSRDEPASLLGDLVWLGTDSRKILIYSA------- 1630
             |...:|.| .:||..||::    ...:|.....|..|.:|:.:.:|.....|::|.:
Zfish   942 -RSVKSFSL-GSQVLCLEYITEPSTEEEQETQASEVPSKIGNTICVGLLDGNIMVYGSVDTAAQC 1004

  Fly  1631 ----RNPEQ-----EEQLGSYSVPGAVQRILYHFDAVYVALSGATVLIF-RRGNDGVWQLRDPQT 1685
                .|||:     .:.||::               ::..||...|.:: |:..:|:|   ||.:
Zfish  1005 LLTFCNPERCHVLCLKHLGNF---------------LFAGLSNGKVAVYNRKSGEGLW---DPDS 1051

  Fly  1686 IR---LGDTDLVVPSLLPINMCIYASCGNRVYVMNALNGEIQRSFEVQHGATQQVNLMAHSGIGL 1747
            .|   :|...::  .||.|:.|::|||.|:|.|:...:...| ||||.......|..|..:|.|:
Zfish  1052 CRHVVIGYAPIL--KLLRIDQCVWASCANQVSVIEGSSLRTQ-SFEVHPDPMVSVTHMVRAGGGV 1113

  Fly  1748 WISLKNSTMLCLYHTETFKHLQDINIASSVLRHDGKKEQPLNNSSVYVTALMACKGLLWVGTNVG 1812
            |::....:.|.|:||||.:|||:||| |:...:....::|    ::.|::|:.|:|||||||..|
Zfish  1114 WMAFSEGSSLRLFHTETLEHLQEINI-STPSAYFSSAQKP----NLCVSSLLICQGLLWVGTAQG 1173

  Fly  1813 IAVTIPLPRLEGVPIISGGINMSCHAHFGPITFLL---PLIPKVYPAYKPPTVGAAPLVPSMGDD 1874
            |.||:|:|||||:|.|:|....|.:||.||:.|||   .::|:.:......|..   :..:.|.|
Zfish  1174 IIVTLPVPRLEGIPKITGKGMTSLNAHNGPVEFLLATSSVLPQDFLKRDSATDN---VDSNSGGD 1235

  Fly  1875 LQLPAIDADPKIQELD---DGAVVLRRDLAKEEMSSSN--PGADSTASSPRSSKLDKQNSLDQSF 1934
            .:.....::..:|:.|   .|....:..|.:..:.|::  ||...|| .|..:....|::::.|.
Zfish  1236 EKEATNSSEESLQQADATSQGEAKSKGVLLQYHLRSTSRLPGKVLTA-QPEETPDSAQHTVEHSL 1299

  Fly  1935 TAKIRASLANSPAFHRKRFRDDPNRMSKTLPR--GLGAAAAGSGAGG----ASAAGSGTASGNT 1992
            .......|::.|....:    .|...||...|  .:.:||..||..|    |:::.|..:|.||
Zfish  1300 EDGSIYELSDDPEVWVR----GPGTTSKEAGRREKVTSAAVISGGKGFRRLANSSHSAESSENT 1359

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43658	NP_001259643.1	RhoGEF	984..1153	CDD:279015	83/168 (49%)
arhgef10lb	XP_009295163.1	RhoGEF	418..602	CDD:238091	94/183 (51%)
		WD40 repeat	911..949	CDD:293791	11/52 (21%)
		WD40 repeat	953..1009	CDD:293791	10/55 (18%)
		WD40 repeat	1015..1047	CDD:293791	7/46 (15%)
		WD40 repeat	1052..1094	CDD:293791	14/44 (32%)
		WD40 repeat	1100..1138	CDD:293791	14/37 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	187	1.000	Domainoid score	I3267
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D43489at33208
OrthoFinder	1	1.000	-	-		FOG0002580
OrthoInspector	1	1.000	-	-		otm24921
orthoMCL	1	0.900	-	-		OOG6_106477
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820