Protein Alignment CG43658 and arhgef33

DIOPT Version :10

• Sequence 1: NP_001259643.1
• Gene: CG43658 / 32729
• FlyBaseID: FBgn0263706
• Length: 2263
• Species: Drosophila melanogaster
• Sequence 2: XP_687624.3
• Gene: arhgef33 / 559216
• ZFINID: ZDB-GENE-131121-574
• Length: 706
• Species: Danio rerio
• Alignment Length: 835
• Identity: 155/835 - (18%)
• Similarity: 238/835 - (28%)
• Gaps: 322/835 - (38%)

  Fly   830 SQREEATTPGESPGGRLSRWFSIRRGSSHQYDVGGRDGRHSTASSFDTPDSGSGNSPKNGSNAVA 894
            |.|....|..|.....|::...:|   |:|.|: .||        .|...|........|..:|.
Zfish    71 SLRNTLNTLQEDVSTALTQLSEVR---SNQKDL-QRD--------LDLMQSTQHRKGSRGEGSVD 123

  Fly   895 GTGGAGSQG--------VALDAASPQKLANLGASKMMPGVPESEDDEATANRFDVDLMMTPGSRA 951
            |.....||.        ::..:|:|...            ||.:..:           .:|..|.
Zfish   124 GHASLNSQTEISLIQHYISSLSANPNPF------------PEHDGQK-----------KSPVWRE 165

  Fly   952 NGTARTAHNRLIVPMLPPAPAGLSQQQLKRRHIVAAIVHSENSYVATLQRLVN------------ 1004
            ...:|..:|..|.               :|:.....::.||..||:.|..|:.
Zfish   166 RKNSRELNNSTIT---------------QRQAAALELLESERVYVSYLSLLLKANISFNGSENVN 215

  Fly  1005 -DYKKPLEECSPPVLNPV--KIATLFHCLPD-ILHSHKLFRISLAECVRNWDRDEKIGDCFVSAF 1065
             ..|:|.    ||.|..:  :...|.|.|.: :|.||             |  ...:||.|:...
Zfish   216 LKDKRPF----PPSLRFLIQQHLELLHLLQERVLKSH-------------W--HGIMGDVFLRLT 261

  Fly  1066 GK-PQLLEIYSGFINNFSAAMELAKMEEKRKSALADFFKVKQISAHDRLSFFGLMVKPVQRFPQF 1129
            .| ...|:.|..::.:....:.:..:....||  ....:........|.:.:.|:::||||.|::
Zfish   262 SKESDFLDHYVSYLRDLPECLTVVSLFSSSKS--GSLLESDMTGDETRPTLYSLLLQPVQRIPEY 324

  Fly  1130 ILFLQDLLKYTPQGHHDRMSLQLALSQLELLAELLNESKREAEQYQAFKEMLGHISGTFNARSLS 1194
            ...||.||:.|...|.|...|.:::.||.......|      ...|..:|:|.|
Zfish   325 HTLLQSLLQQTESEHPDYYLLLVSVQQLRSFMTQYN------HLLQHNQELLTH----------- 372

  Fly  1195 LSSVSVSDSAGGHRPRYLLREDNVTHMEFNQAGFIVKCKQRRLLLLNDKVICVSVAPKQSHDFGA 1259
                           .:.|||.  ||.                       :|.....:.||....
Zfish   373 ---------------SHALREH--THN-----------------------LCTHQQERPSHTRKE 397

  Fly  1260 TEKLTFKWMFPVNDVEIVDNSTSATLSRILTAGLNRGGSLKSNGSSGANGSPYANSTLPGHGGGV 1324
            ..:.|.:.::.| |.|                        |:..||..|.:...|...|.:
Zfish   398 LSRSTVRQLYKV-DYE------------------------KNYSSSTQNDASRRNKRYPDY---- 433

  Fly  1325 SGFSGFGDPHSSPAAQLTNGADNLCSEMSTLMYDYEVISRIQDLVSSLKGSYKELNANTTRNVLN 1389
                                      |.:...||.||.|.:..|..|
Zfish   434 --------------------------EAAPYHYDPEVPSPVSFLSDS------------------ 454

  Fly  1390 LIQGSIQRKDEEMAWVDSCCLQLIGRHKSGKEETFTFQTQTPAVKKEWITELRLAQLALDPNNSP 1454
                            ||       |||:                           :::...:.|
Zfish   455 ----------------DS-------RHKA---------------------------ISVPLRSIP 469

  Fly  1455 AWERGGSHPQPAHHHPHHHPLQHPHAGAGDPRQTQEQLQLQEAVQQKQSRKMPLFVKAMPVYKSQ 1519
            ..|..||....|     ..|| :|: ||||.|.:........::.       ..||:..|.:...
Zfish   470 ETEGAGSVLADA-----LGPL-YPY-GAGDSRCSSPSHSSDSSID-------IAFVRCSPSHSPP 520

  Fly  1520 HQTEVR----CGCYYSIANDTKQSGNA------------RRRHKQLNYLWMCSSDGTSSHITVLA 1568
            .|:..|    .|..|. .|.|..|.::            :|:.|.||.|.|.|.|..:|. |...
Zfish   521 RQSHNRGRSAGGVVYR-PNRTCVSPDSADIVRPRPLQAVQRKSKSLNGLQMDSIDSLNSQ-TKNP 583

  Fly  1569 QHP----QQAG--NLREAGAFDLFETQVSALEFVKGLDQLKSRDEPASLLGDLVW 1617
            .||    |.:|  .||.:.....:||.....|..:...|..||        .|||
Zfish   584 AHPRLERQSSGKSRLRASSPKHRYETHTDTEEQPRLTHQKDSR--------SLVW 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43658	NP_001259643.1	RhoGEF	984..1153	CDD:459876	41/185 (22%)
		PH_19	1210..1376	CDD:465965	26/165 (16%)
		WD40_2	1551..>1846	CDD:465964	21/73 (29%)
arhgef33	XP_687624.3	None