DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG43658 and ARHGEF10L

DIOPT Version :9

Sequence 1:NP_001259643.1 Gene:CG43658 / 32729 FlyBaseID:FBgn0263706 Length:2263 Species:Drosophila melanogaster
Sequence 2:NP_060595.3 Gene:ARHGEF10L / 55160 HGNCID:25540 Length:1279 Species:Homo sapiens


Alignment Length:1110 Identity:333/1110 - (30%)
Similarity:510/1110 - (45%) Gaps:222/1110 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   965 PMLPPAPAGLSQQQLKRRHIVAAIVHSENSYVATLQRLVNDYKKPLEECSPPVLNPVKIATLFHC 1029
            |.|.|.|.|||.||:.||||:.:||.||.|||.:|:|::.||:.||.|..|..|:..|...:|..
Human   301 PELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFR 365

  Fly  1030 LPDILHSHKLFRISLAECVRNWDRDEKIGDCFVSAFGKPQLLEIYSGFINNFSAAMELAKMEEKR 1094
            :.:|||.|.:|:|:|:..|..||..|||||.||::|.|..:|::||.::|||::||.:.|.....
Human   366 VKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACLT 430

  Fly  1095 KSALADFFKVKQISAHDRLSFFGLMVKPVQRFPQFILFLQDLLKYTPQGHHDRMSLQLALSQLEL 1159
            |.|..:|.|.:|:.:.||::.:||||||:||||||||.|||:||.||:||.||:||||||::||.
Human   431 KPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELET 495

  Fly  1160 LAELLNESKREAEQYQAFKEMLGHISGTFNARSLSLSSVSVSDSAGGHRPRYLLREDNVTHMEFN 1224
            |||.|||.||.|:|....:::...:|...:...|..|.           .|.||..:.:|...:.
Human   496 LAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSG-----------QRQLLLCETLTETVYG 549

  Fly  1225 QAGFIVKCKQRRLLLLNDKVICVSVAPKQSHDFGATE---------KLTFKWMFPVNDVEIVDNS 1280
            ..|.::|.|:||:.||||.::|.::..|.::..|..|         |...||...:..|::|:  
Human   550 DRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSLVPLGPKYVVKWNTALPQVQVVE-- 612

  Fly  1281 TSATLSRILTAGLNRGGSLKSNGSSGANGSPY-ANSTLPGHGGGVSGFSGFGDPHSSPAAQLTN- 1343
                                    .|.:|..| .::.|..|.|.         ..:|.:.|..| 
Human   613 ------------------------VGQDGGTYDKDNVLIQHSGA---------KKASASGQAQNK 644

  Fly  1344 ---GADNLCSEMSTLMYDYEVISRIQDLVSSLKGSYKELNANTTRNVLNLIQGSIQRKDEEMAWV 1405
               |...|..|:..|..|..|:.:|..|:|:|.|:|:.||....::....:|..::.|:||:...
Human   645 VYLGPPRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSA 709

  Fly  1406 DSCCLQLI--GR-HKSGKEETF--TFQTQTPAVKKEWITELRLAQLALDPNNSPAWERGGSHPQP 1465
            :.|.|:|:  |: .|||:..:|  .|.|..|..|..|:..|.||::.|...|.|.|         
Human   710 NKCRLRLLLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGW--------- 765

  Fly  1466 AHHHPHHHPLQHPHAGAGDPRQTQEQLQLQEAVQQKQSRKMPLFVKAMPVYKSQH---------Q 1521
                                      |...|..:.|.....|:....:|.:.|:.         .
Human   766 --------------------------LCPDEDKKSKAPFWCPILACCIPAFSSRALSLQLGALVH 804

  Fly  1522 TEVRCGCY-YSIANDTKQSGNARRRHKQLNYLWM-CSSDGTSSHITVLA-QHPQQAGNLREAGAF 1583
            :.|.|... :|..:.:...|          |||: ...:|....:.:.: ..|..    |...:|
Human   805 SPVNCPLLGFSAVSTSLPQG----------YLWVGGGQEGAGGQVEIFSLNRPSP----RTVKSF 855

  Fly  1584 DLFETQVSALEFVKGL-DQLKSRDE------PASLLGDLVWLGTDSRKILIYSARNPEQEEQLGS 1641
            .| ...|..:|::..| ::.:||||      |::.:...:.||.....||:||:.: ...:.|.|
Human   856 PL-AAPVLCMEYIPELEEEAESRDESPTVADPSATVHPTICLGLQDGSILLYSSVD-TGTQCLVS 918

  Fly  1642 YSVPGAVQRIL------YHFDAVYVALSGATVLIFRRGNDGV-WQLRDPQ---TIRLGDTDLVVP 1696
            ...|| :|.:|      :|   :...|...|:..:.|.:.|| |.|..|.   |:..|.    |.
Human   919 CRSPG-LQPVLCLRHSPFH---LLAGLQDGTLAAYPRTSGGVLWDLESPPVCLTVGPGP----VR 975

  Fly  1697 SLLPINMCIYASCGNRVYVMNALNGEIQRSFEVQHGATQQVNLMAHSGIGLWISLKNSTMLCLYH 1761
            :||.:...::||||.||.|:.|...:.|:|||........|..|..:|.|:|::..:.|.:.|:|
Human   976 TLLSLEDAVWASCGPRVTVLEATTLQPQQSFEAHQDEAVSVTHMVKAGSGVWMAFSSGTSIRLFH 1040

  Fly  1762 TETFKHLQDINIAS-SVLRHDGKKEQPLNNSSVYVTALMACKGLLWVGTNVGIAVTIPLPRLEGV 1825
            |||.:|||:||||: :.....|:|.       :.||:|:.|:|||||||:.|:.|.:|:|||||:
Human  1041 TETLEHLQEINIATRTTFLLPGQKH-------LCVTSLLICQGLLWVGTDQGVIVLLPVPRLEGI 1098

  Fly  1826 PIISGGINMSCHAHFGPITFLLPLIPKVYPAYKPPTVGAAPLVPSMGDDLQLPAIDAD-PKIQE- 1888
            |.|:|...:|.:.|.||:.||              .|..:.|.|   |.|:....:|: |:.:| 
Human  1099 PKITGKGMVSLNGHCGPVAFL--------------AVATSILAP---DILRSDQEEAEGPRAEED 1146

  Fly  1889 LDDGAVVLRRDLAKEEMSSSNPGADSTASSPRSSKLDKQNSLDQSFTAKIRASL--------ANS 1945
            ..||.       |.|.|..|:.|.:.|    |...:..|..|..  ||.:...|        |:.
Human  1147 KPDGQ-------AHEPMPDSHVGRELT----RKKGILLQYRLRS--TAHLPGPLLSMREPAPADG 1198

  Fly  1946 PAFHRK-------RFRDDPNRMSKTLP-------RGLGAAAAGSGAGG----ASAAGSGTASGNT 1992
            .|....       ...|||:...::.|       :.:.:.|..||..|    .||.||   ||..
Human  1199 AALEHSEEDGSIYEMADDPDIWVRSRPCARDAHRKEICSVAIISGGQGYRNFGSALGS---SGRQ 1260

  Fly  1993 SQHGE 1997
            :..||
Human  1261 APCGE 1265

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG43658NP_001259643.1 RhoGEF 984..1153 CDD:279015 82/168 (49%)
ARHGEF10LNP_060595.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..91
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 159..197
RhoGEF 317..501 CDD:238091 93/183 (51%)
WD40 repeat 927..970 CDD:293791 11/45 (24%)
WD40 repeat 978..1007 CDD:293791 11/28 (39%)
WD40 repeat 1016..1046 CDD:293791 11/29 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1135..1163 9/34 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1186..1208 3/21 (14%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165147900
Domainoid 1 1.000 235 1.000 Domainoid score I2375
eggNOG 1 0.900 - - E1_KOG3522
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D43489at33208
OrthoFinder 1 1.000 - - FOG0002580
OrthoInspector 1 1.000 - - otm41349
orthoMCL 1 0.900 - - OOG6_106477
Panther 1 1.100 - - LDO PTHR12877
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5001
SonicParanoid 1 1.000 - - X2754
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1110.780

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