DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG43658 and PsGEF

DIOPT Version :10

Sequence 1:NP_001259643.1 Gene:CG43658 / 32729 FlyBaseID:FBgn0263706 Length:2263 Species:Drosophila melanogaster
Sequence 2:XP_061507031.1 Gene:PsGEF / 3289835 VectorBaseID:AGAMI1_000312 Length:2142 Species:Anopheles gambiae


Alignment Length:2570 Identity:431/2570 - (16%)
Similarity:757/2570 - (29%) Gaps:905/2570 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 QQKLQQQQQQQQQQQLEAV-------------------------HGGV----------AKQCLQF 100
            |.||..||:...::.|.|:                         .|||          ..||:..
Mosquito    23 QNKLLLQQRHNARRSLGALSECVTAVTTNSNTIGGSRNKKARRSFGGVIHVACTNYDKENQCITS 87

  Fly   101 PPPPDYPPPITGGGGSPV--------------------NTTP-GRRQQLPRYPDP----DPDAIE 140
            .|.|:..   ....|||.                    |||| ||::.||..|..    ..:.||
Mosquito    88 TPHPNIG---RAASGSPYSMALRDVSNITPSTTPCRQSNTTPLGRKRALPVSPVSASFNQKEQIE 149

  Fly   141 ICNE-------SATLETSPYHLKQ--------LAARHSKTLGR---------------------- 168
            ...|       |..:|.||..:|.        ||:......||                      
Mosquito   150 NIRETYATTLPSFDIEYSPCGVKNIPFLALRGLASTEFDKPGRYFSADEKAPTPKKIKAFVKPML 214

  Fly   169 -----------NLG---------------HQPHHHHTVHLHHDYSYAYYEPGAAM---------R 198
                       ||.               .:.:::.|....:..:..:..|.|.:         .
Mosquito   215 VDNFSTEFVEDNLNPCVTPLSSKMSEIRCSKTNYNRTFSTVNKTANVFLLPSAPLIAPSSSDIDN 279

  Fly   199 HSNVPGAVSSGGGGGGGGAGRVSSVVDTSSSSSPTAEPPPNSIRALLSKGKKNKQLVSPA----- 258
            ..|...:::|...|.......:.::::::...:......||  |:|..|.|.:| |.||.     
Mosquito   280 IENTELSLNSSEMGDLTLDKMIDAILESAKKENHWTTQRPN--RSLSVKSKLSK-LSSPTYTPAD 341

  Fly   259 ----------TLQSYQTRYHKLTT-----KSGMGQSE-----NFYEEINAAALQTSSGHHLRSTV 303
                      :|.....|:.:.||     .|.:.:.|     ..:|::.:..:..|...:.|.::
Mosquito   342 DPAADLYLEQSLPLQMLRHDRETTMINEETSKLNEREVKTPDIKHEKLCSTVINISKADYTRQSI 406

  Fly   304 GSHSAGSLNQTLVEEELRRVQNRHHKI------------LGELNLSVEAMLMPESP--PKS---- 350
            ..|...|..:|......::...|.||:            ..|..|....:..||:|  |.|    
Mosquito   407 TKHIRASPLETACHLRRQKAVRRKHKLEAANNDAILYANTDEYRLDNNQITSPETPYIPCSQSKF 471

  Fly   351 --IDQQPLGSGSGGSGGAEATPP-QPSVSVTAASGQPPTILARLTSASADNICDSGGEAGKRTKT 412
              |::....:.:...|..:..|| |..:|..|.....|..|                 .|..|.|
Mosquito   472 IQINEMQTPNRNDYQGQEQENPPTQFKLSDNATPDIRPIDL-----------------QGTSTPT 519

  Fly   413 APGCPGGGVEQLLTTTCGDLDSGFSGSSGASYIGSLRLSKTQHIKCARQTPTVGTQSCRSFQRAA 477
                 ||.:|  ::..|.|    ||.:.|.:.|...|              :|.:.:...:.||:
Mosquito   520 -----GGSIE--ISRKCLD----FSPTLGDNSIDKRR--------------SVASTTSSRYSRAS 559

  Fly   478 TVYDEAGMSGGGGQSGSSFLT-RASCGRR----ILSCARIRAAEDPGPNHRIAGGNGIQTVQTTA 537
            |      ::|.....|:..|: .....||    ::.|..::....||               :||
Mosquito   560 T------LTGACSVRGTLELSIYLEPDRRLHVHVIRCKDLQRNCFPG---------------STA 603

  Fly   538 TESKARSFWSRKGWRKLPGFSTSTSSINDTGLSDEHKLNSGSWEDTLDEPHHHHAHHSHHQQHL- 601
            |.:...::           ...:...|.||..:.|.:|  |....|:    |.::::.::.|.. 
Mosquito   604 TNNVINAY-----------VKVALIHIGDTNQTTEKEL--GFQRTTV----HRNSNNPYYDQRFI 651

  Fly   602 ------HQHHSHLSQRHQQQQQQQQQLQQTSFIGS---PPSSASI------------------TT 639
                  .:....|:..|     :.::::::.|:|.   |..:.::                  ||
Mosquito   652 FEIYPNDERRIQLAVWH-----RDREIKRSEFLGCTSFPIKNVTVQDINGAYRLQPQSCLTNPTT 711

  Fly   640 AQLHSAFSRRIAEQRERDQRDQRDQREAVG---CTAATIAGGSFSANGGQAAVGVGVGSSSSCGS 701
            ..|.:......:...|....:.....:|..   .|..::..|:...|.|.....:.:        
Mosquito   712 PILETMCENSESSMEELINNEDNSSAKATSINTSTTVSLPTGAILGNNGHNGEEISL-------- 768

  Fly   702 SSERDTKSPCRERD-------RNLERDRDRERDKNDDLGEEEVLTEEEQTSSSV---SSLSAGNQ 756
                 :|....:||       |.||.|...:...|:.:..::|.|...::|.|.   |..:||. 
Mosquito   769 -----SKKAIHQRDADENLFLRFLELDPSPDATSNNAIVGQQVPTTPRRSSISTCGPSKPTAGT- 827

  Fly   757 RNSQLRSTFNKAKQHLSF-----------------DKWRTAATGSATGSASGPGSSATDSNNAAS 804
            .|...|:.|...|:....                 :|..|..:....|...|......|.:|.. 
Mosquito   828 TNPSGRTPFTITKRLTRMGDRGFGFSIVWTHPPRVEKIETGLSADRAGILPGDYVVFVDKHNVV- 891

  Fly   805 NMIMRRASACTMPSSGGGGGAGVGSSQREEATT--------PGESPGGRLS-RWFSIRRGSSHQY 860
                      |||..      .|.:..|.:..|        |..:.|.:|| |...:|..||.|.
Mosquito   892 ----------TMPEQ------DVLNLIRTQGNTLLLEIFRRPQSASGPQLSNRTNGVRNISSGQT 940

  Fly   861 DVGGRDGRHSTASSFDTPDSGSGNSPKNGSNAVAGTGGAGSQGVALDAASPQKLANLGASKMMPG 925
            .:....|                        .:..||...|..|:..:|..|             
Mosquito   941 SISNHGG------------------------MINSTGNITSFNVSSSSAHVQ------------- 968

  Fly   926 VPESEDDEATANRFDVDLMMTPGSRANGTARTAHNRLIVPMLPPAPAGLSQQ--QLKRRHIVAAI 988
               ::|.|..|:.....:..:..:.:|.:...|..:|.:|.:..:...:.||  ...||..:..:
Mosquito   969 ---ADDGEPFASPSPFGVARSSTACSNTSIEIAKRKLHLPQVTFSKESIVQQYPDDHRRKFLYQL 1030

  Fly   989 VHSENSYVAT----LQRLVNDYKKPLEECSPPVLNPVKIATLFHCLPDILHSHKLFRISLAECVR 1049
            :..|..::..    ::|.||..::..:..||   |..||  ||..:.:      |.|||      
Mosquito  1031 ISREQHFINAINFGIERFVNPLRERKDLISP---NDHKI--LFQNIDE------LSRIS------ 1078

  Fly  1050 NWDRDEKIGDCFVSAFGKPQLLEIYSGFINNFSAAMELAK---------------------MEEK 1093
                 |.|.:..:....:||:         :|::.:.|:|                     :..|
Mosquito  1079 -----EDILEQIIQDDTEPQI---------HFASRVYLSKNTALCAAYRKYCNGLKKADCVLVNK 1129

  Fly  1094 RKSALADFFK--VKQISAHDRLSFFGLMVKPVQRFPQFILFLQDLLKYTPQGHHDRMSLQLALSQ 1156
            .::::.||.|  .:......|......:.:|:|.|.:.:..:|.:..:......:..:....:|:
Mosquito  1130 SRNSICDFMKFITEPPVPRKRPDLTTFIHRPLQHFREILKLVQMIASHCRVDSEEHANFNNIISE 1194

  Fly  1157 LEL----------LAELLNESK-----REAEQYQAFKEMLGHISGTFNARSLSLSSVSVSDSAGG 1206
            |::          |.|.:.|.:     ::.|....|.:          .:...|:|         
Mosquito  1195 LQIAYREITVGGGLMEPIGEGRPLLTLQDLEARMVFTK----------CKPFQLAS--------- 1240

  Fly  1207 HRPRYLLREDNVTHME-----------FNQAGFIVKCKQRRLLLLNDKVI--------CVSVAPK 1252
            |..:::...| ::.:|           |:......|..:.|:|.:.::.|        |.::..|
Mosquito  1241 HGRQWIFGGD-LSRIEGRSVKPYWTLLFSDILLFAKVSRDRVLFITEEPITLSTITDSCFNIRKK 1304

  Fly  1253 QSH---------------------DFGATEKLTFKWMFPVNDVEIVDNST--SATLSRILTAGLN 1294
            .:.                     |...|.|..||..:    :.:...||  .|....:||..:.
Mosquito  1305 NTEFRITIDPNARQIESPTVHCAPDLTRTPKKNFKKRY----ISLRAPSTELKAVWQNLLTRQIF 1365

  Fly  1295 RGGSLKSNGSSGANGSPYANSTLPGHGGGVSGFSGFGDPHSSPAAQLTNGADNLCSEMSTLMYDY 1359
                             ..|:||        |.:....|..||            ..:.:.:...
Mosquito  1366 -----------------LVNATL--------GSTPMSSPLDSP------------DILQSFLPFT 1393

  Fly  1360 EVISRIQDLVSSLKGSYKELNANTTRNVLNLIQGSIQRKDEEMAWVDSCCLQLIGRHKSGKEETF 1424
            ::.:.:....|...||   ||:...:|..:.:....:|.||   .:|..|.:|   :|:|..:. 
Mosquito  1394 DIGTTVTSAASVKVGS---LNSMQIKNQQSGVSKVPKRVDE---LIDEKCRKL---NKTGVPQG- 1448

  Fly  1425 TFQTQTPAVKKEWITELRLAQLALDPNNSPAWERGGSHPQPAHHHPHHHPLQHPHAGAGDPRQTQ 1489
                          :.|.|||          |.:|..:.|.....|..          .||    
Mosquito  1449 --------------SALHLAQ----------WMKGQLNKQIIESDPID----------SDP---- 1475

  Fly  1490 EQLQLQEAVQQKQSRKMPLFVKAMPVYKSQHQTEVRCGCYYSIANDTKQSGNARRRHKQLNYLWM 1554
            |||....:|:|..:|...|                         |.....|:..|...:.|    
Mosquito  1476 EQLVEDWSVEQVTNRSKEL-------------------------NLVNSDGSPFRSAPRYN---- 1511

  Fly  1555 CSSDGTSSHITVLAQHPQQAGNLREAGAFDLFETQVSALEFVKGLDQLKSRDEPASLLGDLVWLG 1619
            .||:||......:...|....|   :...|..|...|..:......|:..|..|.|...|.:.:.
Mosquito  1512 GSSNGTLVKNNTINDQPFIDDN---SACDDDDEDNKSVSKSTTSDSQITVRSSPLSNKLDTISMC 1573

  Fly  1620 TDSRKILIYSARNPEQEEQLGSYSVPGAVQRILYHFDAVYVALSGATVLIFRRGNDGVWQLRDPQ 1684
            ....|         ..:.:..|.|....:.:..:...:.:..:|.:|.     |:.....:....
Mosquito  1574 RQCLK---------NCKSRFNSPSTNSLIVQQSHCTSSNHCCVSNSTT-----GSSLDKSINSTS 1624

  Fly  1685 TIRLGDTDLVVPSLLPINMCIYASCGNRVYVMNALNGEIQRSFEVQHGATQQVNLMAHSGIGLWI 1749
            :|....| |.:|.........:..|..:::|                  ||......|..|.:..
Mosquito  1625 SISSSST-LTMPGRQNAGCSNHVECAKKIFV------------------TQTAENYEHKQISIND 1670

  Fly  1750 SLKNSTMLCLYHTETFKHLQDINIASSVLRHDGKK--EQPLNNSSVYVTALMACKGLLWVGTNVG 1812
            |.|....:..:...|.|..:...::.....|:..|  |...|.||                .||.
Mosquito  1671 SYKTMCQISCHCKCTAKDFEKSTLSPDNCLHERVKILENACNVSS----------------RNVS 1719

  Fly  1813 IAVTIPLP-RLEGVPI------------------------ISGGINMSCH-----------AHFG 1841
            |......| ::.|.|.                        |...:|.:..           |...
Mosquito  1720 IQQVKQNPTKMNGFPFNGFPFNPSLKERNAQESCIRDVYKIEDNVNKNDDTAWSLMSLIGLAQIN 1784

  Fly  1842 PITFLLPLIP-KVYP--AYKPPTVGA--------APLVP---SMGDDLQLPAIDADPKIQELDDG 1892
            |.:.|:.|.| :|.|  |..|||..|        .|::|   ...:.|||    |...:...::.
Mosquito  1785 PTSSLVQLDPFEVLPTIAVVPPTPDAFGNAGCIRKPMLPWTTIESNHLQL----APSTLSVTENS 1845

  Fly  1893 AVVLRRDLAKEEMSSSNPGADSTASSPRSSKLDKQNSLDQSFTAKIRASLANSPAFHRKRFRDDP 1957
            .|.|     .:|.|..|...|.....|       ..:|:.|.                ||:    
Mosquito  1846 EVAL-----NDEYSPDNSPEDEIVEPP-------YRALNPSL----------------KRY---- 1878

  Fly  1958 NRMSKTLPRGLGAAAAGSGAGGASAAGSGTASGNTSQHGEHGICDVYGLYGKLIFVKEDYDAE-- 2020
                            |:.:.........|....|....|...||:      .|..||.||..  
Mosquito  1879 ----------------GTISSLERVPSEDTDDNKTFSSDEDSECDI------KIVTKEVYDNNTQ 1921

  Fly  2021 -----EGNQGNLMDMMYEGMRRSDPELAAIPGKVCTLDRRLRMKASRPRSLDLSN--W-SVDSKS 2077
                 ....||.::           |..|.      :||.|..:.:....::.:|  | ....|.
Mosquito  1922 TFLNWTARAGNFIE-----------ESRAF------IDRYLGRRDNSTEEVEANNNDWEKCREKR 1969

  Fly  2078 SSLYTSS-GSEESMGIRHFGGRSVSRNSSSASHKTSGTGSD----LGNISENGLMTTADIHHHQQ 2137
            .|.:||| |.:|.....  |..|.:.........|||..:|    .|:|.:.          |..
Mosquito  1970 VSEHTSSIGCDEEEAFE--GETSATSGEEVWGTPTSGGENDDMQIFGSIEQT----------HSS 2022

  Fly  2138 QQQQLNSSAKPDE----MSRLGAGNSGLDKPAAAVATL-----KRKQ----KQNSKQQQQQNADG 2189
            ..:..:|:...|:    |..|      |..|....:|:     :||.    :::|:..:..:...
Mosquito  2023 PTKSSSSNTGDDDTELMMDEL------LMAPPMTASTVRGLLPRRKLEPLFEEDSESSESDDDSK 2081

  Fly  2190 PRTVITLMGGRGYWRQMWYNGAGGSPSHKNSSSGG 2224
            |      :.||.       |.||.|.:.::||..|
Mosquito  2082 P------LSGRD-------NQAGASYAKQSSSLCG 2103

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG43658NP_001259643.1 RhoGEF 984..1153 CDD:459876 31/195 (16%)
PH_19 1210..1376 CDD:465965 28/207 (14%)
WD40_2 1551..>1846 CDD:465964 50/332 (15%)
PsGEFXP_061507031.1 None

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