Protein Alignment CG43658 and PsGEF

DIOPT Version :9

• Sequence 1: NP_001259643.1
• Gene: CG43658 / 32729
• FlyBaseID: FBgn0263706
• Length: 2263
• Species: Drosophila melanogaster
• Sequence 2: NP_996333.4
• Gene: PsGEF / 31224
• FlyBaseID: FBgn0264598
• Length: 2777
• Species: Drosophila melanogaster
• Alignment Length: 2592
• Identity: 484/2592 - (18%)
• Similarity: 793/2592 - (30%)
• Gaps: 914/2592 - (35%)

  Fly   180 VHLHHDYSYAYYEPGAAMRHSNVPGA------------VSSGGGGGGGGAGRVSSVVDTSSSSSP 232
            :|.|...|....|.....|...|||.            :||..|.        :|::.....|:.
  Fly     7 MHRHSSSSAVVEESRGRRRGVGVPGVGDANKENFGVHFMSSPFGN--------ASLIALQDLSNV 63

  Fly   233 TAEPPPNSIRALLSKGKKNKQLVSPATLQSYQTRYHKLTT------------KSGMGQS------ 279
            ..:.|.   |...|:|...:|    ||.|....|....||            .|.||.:
  Fly    64 HGKSPQ---RRSFSEGSGPRQ----ATPQLAALRCLPRTTGGAVALEDSQLSSSRMGDTTLDRML 121

  Fly   280 ----ENFYEEINAAALQTSSGHHLRSTVGSHSAGSLNQTLVEEELRRVQNRHHKILGELNLSVEA 340
                |:..:|:........:|....:|:.:.:|.....::.|.|:|.          ..:|..:.
  Fly   122 DAIIESARKEVRCTKTLPGAGATTSTTILADNAEWSETSVHEMEVRT----------PTHLKRQR 176

  Fly   341 MLMPESPPK--SIDQQPLGSGSGGSGGAEATPPQPSVSVTAASGQPPTILARLTSASADNICDSG 403
            ::..::|.|  :|:|..       |..|:...|...|..|      ...|:..:|:::.::.:..
  Fly   177 VVRRKNPHKTTTINQTQ-------SHQAKKLEPLQLVPST------KRCLSFSSSSASSDLDEDE 228

  Fly   404 GEAGKR------TKTAPG-CPGGGVEQLLTTTCGDLDSGFSGSSG----ASYIGSLRLSKTQHIK 457
            .:..||      |.|.|. |         |||...:.|..|.:.|    ||..||:.:|.....|
  Fly   229 QQVAKRSSLASPTTTPPSHC---------TTTTSSISSSSSSNGGADMEASQRGSIDVSIAFDAK 284

  Fly   458 CARQTPTVGTQSCRSFQRAATVYDEAGMSGGGGQSGSSFLTRASCGRRILSCARIRAAEDPGPNH 522
              .|...|....||..||:         .|.|..|.::::..|..|          .|:.||...
  Fly   285 --EQQLNVHVIRCRDLQRS---------HGSGNGSINAYVKVALSG----------GAQPPGYGG 328

  Fly   523 RIAGGNGIQTVQTTAT-ESKARSFWSRKGWRKLPGFSTSTSSINDTGLSDEHKLNSGSWEDTLDE 586
            ..:||:.....|.||. ....|.::.::       |:...||..:|.   ...|....|
  Fly   329 HSSGGSMSSGYQRTAVHRHSGRPYFDQR-------FNFQISSGEETA---GQYLQLAVW------ 377

  Fly   587 PHHHHAHHSHHQQHLHQ---------------HHSHLSQRHQQQQQQQQQLQQTSFIG------- 629
                     |..:||:.               .....::|..:.:....:.:::.|:|
  Fly   378 ---------HRDRHLNSVPVTQSEWQARVKSGTERRTAERLAKLENAGNEAKRSEFLGCSTFPLN 433

  Fly   630 ---SPPSSASITTAQLH--------SAFSRRIA----EQRE-----RDQRDQRDQREAVGCTAAT 674
               .|.|..|..:.:||        |..|:..|    :|::     :||..|:|...|....|.|
  Fly   434 ELVHPDSGVSAGSYKLHAQACPPPTSRHSQPKANAGQDQKQETEAAKDQDKQQDDSPAEMAAAVT 498

  Fly   675 IAGGSFSANGGQAAVGVGVGSSSSCGSSSERDTKSPCRERDRNLERDRDRERDKNDDLGEEEVLT 739
            :.        .|..|..|.||.|:..:.:..|.....                ..|.:|:|:.|.
  Fly   499 VT--------PQKPVATGSGSGSNSAAMALNDEVISI----------------SIDSMGKEDPLL 539

  Fly   740 EEEQTSSSVSSLSAGNQRNSQ----LR-------------STFNKAKQHLSFDKWRTAATGSATG 787
            .::.......|..|.:||::.    ||             ||..:|:           ||||.:.
  Fly   540 PQQPQQPMKLSKKALHQRDADENLFLRFLELDPPADGNANSTTTQAQ-----------ATGSQSS 593

  Fly   788 SASGPGSSATDSNNAASNMIMRRASACTMPSSGGGGGAGVGSSQREEATTPGESP---GGRLSR- 848
            ::....|:|...||..|.  .||.|  |||:|   ||:.||.:.|::   .|.:|   ..||:|
  Fly   594 ASKANESNANHLNNGTSG--GRRQS--TMPNS---GGSSVGGAVRQQ---QGRTPFTMTKRLTRT 648

  Fly   849 -----WFSI-------------------------------------------------RRGSSHQ 859
                 .|||                                                 .:|||..
  Fly   649 EERGFGFSIVWTHPPRVEKIEAGLSADRCGILPGDYVIFVDKHNVVTMPEADVLNLIRSQGSSLT 713

  Fly   860 YDVGGRDGRHSTASSFDTPDSGSGNSPKNGSNAVAGTGGAGSQ-----GVALDAASPQKLANLGA 919
            .::..|.|  :.|::..:.|.|..|  .:.|..:....|.||:     ..|....:...|....:
  Fly   714 LEIFRRSG--AGATTITSTDLGQNN--VHISTRLGAAVGLGSEEHTLATTATGTTTVMSLQRTTS 774

  Fly   920 SKMMPGVPESEDDEATANRFDVDLMMTPGSRANGTA---RTAHNRLIVPMLPPAPAGLSQQQLKR 981
            :::.|          .||.     |..|.:..:||.   ..|..||.:|.:..:...:......|
  Fly   775 TRIQP----------LANS-----MSRPATACSGTTSSIEAAKRRLHLPQVTFSKESIVPVTDNR 824

  Fly   982 RHIVAAIVHSENSYVATLQRLVNDYKKPLEECSPPVLNPVKIATLFHCLPDILHSHKLFRIS--L 1044
            |..:..::..|.::.|.|...|:.:.:||.| ...:::|....|||..:.::|      ||:  :
  Fly   825 RRFLLQLISREQNFTAALHFGVDRFVQPLGE-RKDLISPNDHRTLFQNIDELL------RIAEDI 882

  Fly  1045 AECVRNWDRDEKIGDCFVSAFGKPQLLEIYSGFINNFSAAMELAKMEEKRKSALADFFK-----V 1104
            .|.:.:.|:.::          :||:         ||::.:.|:|     .:|:...:|     :
  Fly   883 LEQLCSSDQQDQ----------EPQM---------NFASRVYLSK-----TTAICAAYKKYCNGI 923

  Fly  1105 KQI-------SAHDRLSFFGLMVKPV--QRFPQFILFLQDLLKYTPQGHHDRMSLQLALSQLELL 1160
            |:.       |......|...:.:|.  ::.|...:|:...|:      |.|..|:|    ::||
  Fly   924 KRADCVLVNKSRQTGSEFIAFITEPAVPRKRPDLTMFIHRPLQ------HFREILKL----MQLL 978

  Fly  1161 AELLNESKREAEQYQAFKEMLGHISGTFNARSLSLSSVSVSDSAGGHRPRYLLREDNVTHMEFNQ 1225
            |   .....:.|:::.|..::..:...:  |.:::|| .:.:..|..|| .|..:|..:.|.|
  Fly   979 A---GNCHVDTEEHKNFSTVINELQAAY--REITVSS-GLMEPLGEGRP-LLTLQDLESRMVF-- 1034

  Fly  1226 AGFIVKCKQRRL--------------------------LLLNDKVICVSVAPKQSHDFGATEKLT 1264
                .|||...|                          ||.:|.::...|         :.:::.
  Fly  1035 ----TKCKPFTLAVQGRQWIFGGDLSRVEGRSVKPYWTLLFSDIIVFAKV---------SRDRVL 1086

  Fly  1265 FKWMFPVNDVEIVDN-----------------------STSATLSRILTAGLNRGGSLKS----- 1301
            |....|:....:||:                       |.:...:..||....||...||
  Fly  1087 FITEEPIPIANVVDSCFHMRKKTTEFRLTVDPNGRLAESPTGYCAPDLTRTPKRGARRKSLILRA 1151

  Fly  1302 --------------------NGSSGAN--GSP-----YANSTLPGHGGGVSGFS----------- 1328
                                |.:.|:.  .||     ..|:.:|....|::..|
  Fly  1152 PSLELKAVWQNLLQRQIFLVNAALGSTPLSSPLDSPDVLNTLVPLSDIGLTTASMGSMKLPSLDS 1216

  Fly  1329 --------------GFGDPHSSPAAQLTNGADNLCS----------EMSTLMYDYEVISRIQDLV 1369
                          ..|..||:........||....          |...|:.|.:  .||.:..
  Fly  1217 IHLKQQQKQQRTNNSHGHVHSATGVATDRTADRSHGHNHGIHGGHVEQIELLIDEK--CRILNKT 1279

  Fly  1370 SSLKGSYKELNANTTRNVLNLIQ-----GSIQRKDEEMAWVDSCCLQLIGRHKSGKEETFTFQTQ 1429
            .:.|.|...| ||..:..|:..|     .:|.|..|.::..|.   |||....|.::|..|:.|:
  Fly  1280 GTPKSSALHL-ANWMKGQLDKQQQQARLAAIARSQENVSAEDE---QLIFNSDSEQDERITYWTR 1340

  Fly  1430 TPAVKKEWITELRLAQLALDPNNSPAWERGGSHPQPAHHHPHHHPLQHPHAGA-GDPRQTQEQLQ 1493
            ....|:  ..||.||:           |.||...:|.........::.....| .|...|.|...
  Fly  1341 QQLEKR--TKELNLAK-----------ENGGLSARPNFGGKRLSGVEELSMSATSDIYSTSEAEG 1392

  Fly  1494 LQEAVQQKQS---------RKMPLFVKAMPVYKSQHQTEVRCGCYYSIANDTKQSGNARRRHKQL 1549
            :...:.|..|         |..|:.:..:.|.:..|:     .|..|.....:..|.....:...
  Fly  1393 VTSVISQSHSTTSDSQITVRSSPIVLDKLAVCRHCHK-----NCQQSGPGGARPGGGGGVNNSSS 1452

  Fly  1550 NYLWMCSSDGTSSHITVLAQHPQQAGN----LRE--AGAFDLFE--------------TQVSALE 1594
            ..:.:|:|        :..||.|.:.|    |..  |||.::..              |.:|:..
  Fly  1453 TPVLLCNS--------LKVQHSQSSPNRCCKLSNGIAGATEMANPKNSNRTGTGTGSVTSMSSST 1509

  Fly  1595 FVKGLDQ----LKSRDEPASLLGDLVWLGTDSRKILIYSARNPEQEEQLGSYSVPGAVQRILYHF 1655
            ....|..    ..||.|......|:..|.||.    |..:::...::.:|  ::|.:.:.
  Fly  1510 ITGELSSKVVASSSRRETGDTESDVAQLITDE----ISQSQSEATDDSVG--AMPNSSRS----- 1563

  Fly  1656 DAVYVALSGATVLIFRRGNDGVWQLR--DPQTIRLGDTDLVVPSLLPINMCIYASCG-------- 1710
                 |..|..|:...|       ||  ||.         |..|.||...|   |.|
  Fly  1564 -----AGEGNPVITGSR-------LRHLDPP---------VSVSSLPNGHC---SAGVGGGSPKP 1604

  Fly  1711 ----NRVYVMNALNGEIQRSFEVQHGATQQVNLMA---------------HSGIGLWIS------ 1750
                .|..|:..:..|..|.     .|.|||..:.               .||.|....
  Fly  1605 LPPPRRTRVVAQMCQEPPRP-----KANQQVKAIVTITETARIMRSSPTKGSGSGSATGTGSVGG 1664

  Fly  1751 --LKNSTMLCLYHTETFKHLQDINIASSVLRHDGKKEQPLNNSSVYVTALMACK------GLLWV 1807
              .|.:...|....|.|.|.|   ::...:.|...|   |..|....|..:..|      .|:.:
  Fly  1665 SPAKYAACHCRCTPEDFTHAQ---LSPDKMEHQTCK---LLESPKQTTTTLEQKQEDEQLSLMLI 1723

  Fly  1808 G-TNVGIAVT------IP-----LPRLEGVPIISGGI----------NMSCHAHFG--------- 1841
            | ..:..|.|      ||     .|.:..||.....:          |..|.::.|
  Fly  1724 GLAQLAPAATLCGQERIPKEENSTPTIAVVPPTPDSVLTKTSTHVWDNSGCSSNGGGTSTTSTAT 1788

  Fly  1842 -----PITFLLPLIPK---------VYPAYKPPTVGAAPLVPSMGDDLQLPAIDADPKIQELDDG 1892
                 |...::..||:         ..|.|:|.: .|.....:|....:||:.|...:..||||
  Fly  1789 TTTKQPRQAIIENIPEDSCDESPLDEEPPYRPMS-SALRRFGTMSSLEKLPSDDRMDEADELDD- 1851

  Fly  1893 AVVLRRDLAKEEMSSSNP-GADSTASSPRSSKLDKQNSLDQSFTAKIRASLANSPAFHRKRFRDD 1956
                       ::.|..| |.|  .:||       ||..|.......||.:.|.
  Fly  1852 -----------DLDSFKPNGHD--GNSP-------QNEEDDEDADSERALVQND----------- 1885

  Fly  1957 PNRMSKTLPRGLGAAAAGSGAGGASAAGSGTASGNTSQHGEHGICDVYGLYGKLIFVKE-----D 2016
                       |||    |.:.|....|.|.|||..:......:.|      |:.|.:|     |
  Fly  1886 -----------LGA----SSSSGVIVNGEGLASGAWTNRAGAYVSD------KMSFFEESRAFID 1929

  Fly  2017 YDAEEGNQGNLMDMMYEGMRRSDPELAAIPGKVCTLDRRLRMKASRPRSLDLSNWSVDSKSSSLY 2081
            ......|.|:......:|......|                              .:|..:|.
  Fly  1930 KYLGRWNAGDAQQQHQQGTASETDE------------------------------QMDECTSG-- 1962

  Fly  2082 TSSGSEESMGIRHFGG----------RSVSRNSSSASHKTSGTGSDLGNISENGL-----MTTAD 2131
             ::..||..|....||          .|.:.:||.....||....|...:..:.|     ||.:.
  Fly  1963 -ATSGEEVWGTPTSGGDNDDQDLQLINSENTHSSPTKSSTSLNDDDDTELMMDELLMAPPMTAST 2026

  Fly  2132 I--------------------HHHQQQQQQLNSSAKPDEMSRLG------AGNSGLDK------P 2164
            |                    ...:::.||.:...|..|.:..|      ||:|...:      |
  Fly  2027 IRGLLPRFYRRRLEPLFEEETESDEEKTQQDSDDIKKGEATTNGHYLEDSAGSSSDSESVPPAPP 2091

  Fly  2165 AAAVATLKRKQKQNSKQQQQQN-----------------------ADGPRTVITLMGGRGYWRQM 2206
            ......:..:::..|.:.||:|                       |.|||.::|.       |.:
  Fly  2092 LVPRPVVPDREEDPSAEGQQENLAMEDQEDLHSSVERLLPNLATSAMGPRPLLTT-------RLL 2149

  Fly  2207 WYNGAGGSP-------------SHKNSSSGGGGGSGSGFSGQTMQSGNPS-CSPLTA 2249
            ........|             ..:.||..|...:|......||.|..|: .||..|
  Fly  2150 PTTAIDPQPPAVLVASSCEYLLDQRPSSVPGRDLAGGSIGTTTMTSSRPTPLSPAKA 2206

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43658	NP_001259643.1	RhoGEF	984..1153	CDD:279015	34/184 (18%)
PsGEF	NP_996333.4	DUF4799	<102..209	CDD:292674	20/123 (16%)
		C2	286..>381	CDD:278593	27/138 (20%)
		PDZ_signaling	644..716	CDD:238492	9/71 (13%)
		RhoGEF	831..1000	CDD:295373	40/212 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3522
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900