Protein Alignment CG43658 and Arhgef10

DIOPT Version :10

• Sequence 1: NP_001259643.1
• Gene: CG43658 / 32729
• FlyBaseID: FBgn0263706
• Length: 2263
• Species: Drosophila melanogaster
• Sequence 2: XP_017168158.1
• Gene: Arhgef10 / 234094
• MGIID: 2444453
• Length: 1468
• Species: Mus musculus
• Alignment Length: 1514
• Identity: 390/1514 - (25%)
• Similarity: 625/1514 - (41%)
• Gaps: 376/1514 - (24%)

  Fly   681 SANGGQAAVGVGVGSSSSCGSSSER--------DTKSPCRERDRNLERDRDRERDKNDDLGEEEV 737
            |...|:|:..|.....:.|.:|:..        |:.....|.||.:....||.|      |.|..
Mouse    84 SMEQGEASPPVPAEHEAKCDTSNNEEEGELFDFDSGDEVPEADRQVPSADDRTR------GAEAG 142

  Fly   738 LTEEEQTSSSVSSLSAGNQRNSQLRSTFNKAK---------------------QHLSFDKWRTAA 781
            ..:|       ::..|||...::.......||                     |..|.|. .|..
Mouse   143 GADE-------NTCPAGNGTGAEPAPEAEPAKLVVPTKVNPYSVIDITPLQEDQPSSPDA-NTEE 199

  Fly   782 TGSATGSASG-----PGSSATDSN-----NAASNMIMRRASAC----TMPSSGGGGGAGVGSSQR 832
            .|......||     |...|..||     .|.|:.::.||.:.    ...:.|.|....:.|...
Mouse   200 EGVGLRVPSGYSVPVPCGYAVPSNLPLLLPAYSSPVIIRAESVEEEEAAETVGDGQCNSLSSEDL 264

  Fly   833 EEATTPGESPGGRLSRWFS------------------IRRGSSHQ------YD--VGGRDGRHS- 870
            ..::..|...|..|:||.:                  :.|.:|..      ||  ..|.:|.:|
Mouse   265 PHSSEQGSQEGSALARWAADPANTAWMENPEEAIYDDVPRENSDSEPDEMIYDDVENGEEGGNSS 329

  Fly   871 -----TASSFDTPDSGSGNSPKNG-----------------------------SNAVAGTGGAGS 901
                 ::|.|::.:..|.:..|||                             ...||.|.|
Mouse   330 PEYGWSSSEFESYEEPSDSEGKNGIPRSFLRSSHKKQLSHDLTRFKAHCEEKMRGLVASTVG--- 391

  Fly   902 QGVALDAASPQKLANLGASKMMPGVPESEDDEATANRFDVDLMMTPGSRANGTART--------- 957
               |::....::.......|:|....|...|.....:..|       .|.....||
Mouse   392 ---AMEIQQAKQRQERKMQKLMKAAKEGTKDGLEKTKAAV-------KRGGSFIRTRSLVSQDHR 446

  Fly   958 ----AHNRLIV--------PMLPPAPAGLSQQQLKRRHIVAAIVHSENSYVATLQRLVNDYKKPL 1010
                ....|.:        .:|.|.|.||||||:.||:|:.:||.||.:||..|:|::..|:|||
Mouse   447 CYFEEEQNLFIDVDCKHPEAVLTPMPEGLSQQQVVRRYILGSIVESEKNYVDALRRILEQYEKPL 511

  Fly  1011 EECSPPVLNPVKIATLFHCLPDILHSHKLFRISLAECVRNWDRDEKIGDCFVSAFGKPQLLEIYS 1075
            .|..|.:|:..|:..:|:.:.:||..|.:|:|:||..|..||..|.|||.||::|.|..:|:.||
Mouse   512 SEMEPRLLSDRKLRMVFYRVKEILQCHSMFQIALASRVSEWDVVETIGDVFVASFSKSMVLDAYS 576

  Fly  1076 GFINNFSAAMELAKMEEKRKSALADFFKVKQISAHDRLSFFGLMVKPVQRFPQFILFLQDLLKYT 1140
            .::||||.|:.:.|.....|.|..:|.|:.|.|:.||::...||::|:||||||||.|||:||.|
Mouse   577 EYVNNFSTAVAVLKKTCATKPAFLEFLKLSQDSSPDRVTLHSLMMRPIQRFPQFILLLQDMLKNT 641

  Fly  1141 PQGHHDRMSLQLALSQLELLAELLNESKREAEQYQAFKEMLGHISGTFNARSLS--LSSVSVSDS 1203
            .:||.||:.||:||::||.|||.|||.||:|:|....|:    |:...|.|.|:  |||.:
Mouse   642 AKGHPDRLPLQMALTELETLAEKLNERKRDADQRCEIKQ----IAKAINERYLNKLLSSGN---- 698

  Fly  1204 AGGHRPRYLLREDNVTHMEFNQAGFIVKCKQRRLLLLNDKVICVSVAPKQSHDFGA--TEKLTFK 1266
                  |||:|.|:|....:|..|.|||.||||:.:|||.::|.:.:.:.||:..|  :::...|
Mouse   699 ------RYLVRSDDVIETVYNDRGEIVKTKQRRIFMLNDVLMCATASSRNSHESHAVMSQRYLLK 757

  Fly  1267 WMFPVNDVEIVDNSTSATLSRILTAGLNRGGSLKSNGSSGAN--------GSPYANSTLPGHGGG 1323
            |..|:..|:::                      :.||.|||.        .||.:.:.:..
Mouse   758 WSVPLGHVDVI----------------------QYNGGSGAGEHCRHHAAHSPESLAVVAN---- 796

  Fly  1324 VSGFSGFGDPHSSPAAQLTNGADNLCSEMSTLMYDYEVISRIQDLVSSLKGSYKELNANTTRNVL 1388
                   ..||     ::..|...|..::..|::|..|:.:|..|:.:|:|||:.||.:...:..
Mouse   797 -------AKPH-----KVYMGPGQLYQDLQNLLHDLNVVGQISQLIGNLRGSYQNLNQSVAHDWT 849

  Fly  1389 NLIQGSIQRKDEEMAWVDSC--CLQLIGRH-KSGKEETFT--FQTQTPAVKKEWITELRLAQLAL 1448
            :.:|..|.||::.:...|.|  .|||.|:. |||:...||  |.|.|||:|:.|::.|::|:|||
Mouse   850 SGLQRLILRKEDAIRAADRCRIQLQLPGKQDKSGRPTFFTAVFNTLTPAIKESWVSSLQMAKLAL 914

  Fly  1449 DPNNSPAW---ERGGSHPQPAHHHPHHHPLQHPHAGAGDPRQTQEQLQLQEAVQQKQSRKMPLFV 1510
            :..|...|   :..|:..:     ...|||...|                          ||:.|
Mouse   915 EEENHMGWFCVDDDGNLAK-----KETHPLLVGH--------------------------MPVMV 948

  Fly  1511 KAMPVYKSQHQTEVRCGCYYS---IANDTKQSGNARRRHKQLNYLWMCSSDGTSSHITVLAQHPQ 1572
            ...|.:|      :.|..|..   ::|:::.:..:..|    .:||:.|.......:.:::   .
Mouse   949 AKQPEFK------IECAAYNPEPYLSNESQPASPSTAR----GFLWIGSCSNQMGQVAIVS---F 1000

  Fly  1573 QAGNLREAGAFDLFETQVSALEFV-----KGLDQLKSRDEPASLLG----DLVWLGTDSRKILIY 1628
            |..|.:....|:: |:::..:.::     |..:..:::|..|:...    ..:.|||:...|.||
Mouse  1001 QGSNPKVIECFNV-ESRILCMVYIPAEESKPQETTETKDPEATASRAPHVPTICLGTEEGSISIY 1064

  Fly  1629 SARNPEQEEQLGSYSVP--GAVQRILYHFDAVYVALSGATVLIFRRG------------------ 1673
            .:....::.:|..:..|  ..|..:......:|..|...:|..:.:.
Mouse  1065 KSSQGCKKVRLQHFYAPDKSTVMSLACSPQGLYAGLVNGSVASYTKAPAPSSPGSPWAEFCLICV 1129

  Fly  1674 ---------------------NDGVWQLRDPQTIRLGDTDLVVPSLLPINMCIYASCGNRVYVMN 1717
                                 ..|.|.....|.|:||  .|.|.|||.:...::|:.|.:|::.:
Mouse  1130 FLPCLPSGAYAISGTGCGAVKGYGSWNSEPQQVIKLG--VLPVRSLLLVEGALWAASGGQVFMAS 1192

  Fly  1718 ALNGEIQRSFEVQHGATQQVNLMAHSGIGLWISLKNSTMLCLYHTETFKHLQDINIASSVLRHDG 1782
            .....|:...|........::.||.:|:|:||:..:.:.|.|:||||.|||||:||
Mouse  1193 VETHTIENQLEAHQDEGMVISHMAVAGVGIWIAFTSGSTLRLFHTETLKHLQDVNI--------- 1248

  Fly  1783 KKEQPLN-----NSSVYVTALMACKGLLWVGTNVGIAVTIPLPRLEGVPIISGGINMSCHAHFGP 1842
              :.|::     :..:.||:|:.|.|||.|||::|:.|.:|:|||:|:|.::|...:|.|||.||
Mouse  1249 --DAPVHSMLPGHQRLSVTSLLVCHGLLMVGTSLGVVVALPVPRLQGIPKVTGRGMVSYHAHNGP 1311

  Fly  1843 ITFLLPLIPKVYPAYKPPTVGAAPLVPSMGDDLQLPAIDADPKIQELDDGAVVLRRDLAKEEMSS 1907
            :.|::..     .|::  ....|...|..|.:||    |.|||             ||...|...
Mouse  1312 VKFIVSA-----TAFQ--NKDRARDSPRSGSELQ----DEDPK-------------DLLCSEEGP 1352

  Fly  1908 SNPGADSTASS---PRSSKLDKQNSLDQSFTAKIRASLANSPAFHRK------RFRDDPNRMSKT 1963
            |.||...|.:|   ..|..|..|.:...|.:..:..|..:|...||.      ....||:...::
Mouse  1353 SCPGQPDTYTSVWLGDSLGLPTQKNDLSSSSGSLNLSHGSSSLEHRSVDSSLCDLLRDPSASPRS 1417

  Fly  1964 LPRGLGAAAAGSG---AGG 1979
            .|:|...|.|.|.   .||
Mouse  1418 RPQGSRRARASSALVVCGG 1436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43658	NP_001259643.1	RhoGEF	984..1153	CDD:459876	76/168 (45%)
		PH_19	1210..1376	CDD:465965	44/175 (25%)
		WD40_2	1551..>1846	CDD:465964	83/349 (24%)
Arhgef10	XP_017168158.1	RhoGEF	482..666	CDD:238091	85/183 (46%)
		PH_19	689..838	CDD:465965	49/196 (25%)
		WD40_2	946..1466	CDD:465964	126/542 (23%)