Protein Alignment CG43658 and osg-1

DIOPT Version :9

• Sequence 1: NP_001259643.1
• Gene: CG43658 / 32729
• FlyBaseID: FBgn0263706
• Length: 2263
• Species: Drosophila melanogaster
• Sequence 2: NP_498172.3
• Gene: osg-1 / 175756
• WormBaseID: WBGene00019832
• Length: 1182
• Species: Caenorhabditis elegans
• Alignment Length: 1380
• Identity: 283/1380 - (20%)
• Similarity: 497/1380 - (36%)
• Gaps: 355/1380 - (25%)

  Fly   676 AGGSFSANGGQAAVGVGVGSSSSCGSSSERDTKSPCRER-DRNL----ERDRDRERDKNDDLGEE 735
            |..|.|:......|.|.....|:..|.|.|::....|.| |.||    ||:|.|||.::......
 Worm     7 ADDSDSSTDSSPPVAVPRPKRSATVSPSTRNSFYNSRRRSDANLNFFNERERQRERRRSMVRASR 71

  Fly   736 EVLTEEEQTSSSVSSLSAGNQRNSQLRSTFNKAKQH--LSFDKWRTAATGSAT---GSASGPGSS 795
            |  ..|.:.:|..:.....::.|..:.|...:|.|.  ||..|:.:|:.....   .|.|| |..
 Worm    72 E--RSESRRASQQNLRKTNSEPNVDMPSIDVEALQKLLLSIPKFVSASRNRINQRHDSDSG-GEM 133

  Fly   796 ATD----SNNAASNMIMRRASAC-TMPSSGGGGGAGVGS-----------SQREEATTPGESPGG 844
            .|:    .:.|.|...::|..|. :..||..||...:..           |..:|::...::..|
 Worm   134 TTEIEELKDAAKSIQSLQRVLAYPSQTSSDRGGNRRLADPVESCLESSVFSDVDESSLATDTIEG 198

  Fly   845 RLSRWFSIRRG------------SSHQYDVGGRDGRHSTASSFDTPD----SGSGNSP----KNG 889
            |.| ..|.|.|            .:.|:.......|:|.:.....||    |...:.|    :|.
 Worm   199 RRS-GISTRLGHPRGVMQFIPSIRNDQFVPTSEIRRNSISRKSSVPDGFMTSEMESEPVPNVRNR 262

  Fly   890 SNAVAGTGGAGSQGVALDAASPQKLAN-------LGASKMMPGVPESEDDEATANRFDVDLMMTP 947
            ...:.....:.|..:.:|..| :.||.       |...:..|..|| :....:.|.:    :.:.
 Worm   263 RRGIVDEMFSSSTSLLVDRPS-ETLAGVNRFAKLLDTFRSRPTSPE-QHPSISWNPY----VYSD 321

  Fly   948 GSRA---NGTARTAHNRLIVPMLPPAPAGLSQQQLKRRHIVA-AIVHSENSYVATLQRLVNDYKK 1008
            |..|   .|...:.|...|:.....:.|.| ::....||:.| .::.:|.|:|..|:.||..|.:
 Worm   322 GGEALETCGMEDSLHEADILLWKKRSRASL-RRHYSVRHLAARELLDTEKSFVEGLEFLVTKYMR 385

  Fly  1009 PLE---ECSPPVLNPVKIATLFHCLPDILHSHKLFRISLAECVRNWDRDEKIGDCFVSAFGKPQL 1070
            ||.   ||:  ::....:..:|:.:|:||..|::...:|::.:..|.:|..:||..::.|.|..:
 Worm   386 PLRQPLECT--LIEASLVDKIFYRIPEILAHHQVLLTTLSQRIDQWHKDAILGDVLLAHFSKQSM 448

  Fly  1071 LEIYSGFINNFSAAMELAKMEEKRKSALADFFKVKQISAHDRLSFFGLMVKPVQRFPQFILFLQD 1135
            :|.|..|::||..| :.:.::.::|.|...::........::|....|::.|:||.|::.|.::.
 Worm   449 IETYISFVDNFKFA-KASIIQARQKHAFEKYYNRCCRDHPNKLDLDSLLISPIQRVPRYELIVKQ 512

  Fly  1136 LLKYTPQGHHDRMSLQLALSQLELLAELLNESKREAEQY-QAFKEMLGHISGTFNARSLSLSSVS 1199
            :||:||..|.||..|..|...:..||..:|:.|..:||. |..:|:...:.|        |..:.
 Worm   513 MLKHTPVEHEDRERLLRAQRHIHCLAVAINQHKDGSEQMEQRLREIEAIVDG--------LDDLV 569

  Fly  1200 VSDSAGGHRPRYLLREDNVTHMEFNQAGFIVKCKQRRLLLLNDKVICVSVAPK--------QSHD 1256
            ..|       |.|||.|.:|....:        ::|.:.:|:|.::..||..|        .|..
 Worm   570 TKD-------RTLLRHDIITLKGTD--------RERCIFMLSDLLLVTSVKKKPKVLYSKMSSQS 619

  Fly  1257 FGATEKLTFKWMFPV--NDVEIVDNSTSATLSRILTAGLNRGGSLKSNGSSGANGSPYANSTLPG 1319
            .|..|...||.:|.|  .||:|    :..|||::
 Worm   620 MGFLEGNRFKLLFKVALEDVQI----SKDTLSQL------------------------------- 649

  Fly  1320 HGGGVSGFSGFGDPHSSPAAQLTNGADNLCSEMSTLMYDYEVISRIQDLVSSLKGSYK----ELN 1380
                                      :.:..::.:...|..|:.::..|.|.||...|    .|.
 Worm   650 --------------------------EEVERKLESSREDDRVLKKMSQLCSLLKCERKVLMEMLE 688

  Fly  1381 ANTTRNVLNLIQGSIQRKDEEMAWVDSCCLQLIGRHKSGKEETFTFQTQTPAVKKEWITELRLAQ 1445
            ...|.|.:     ||:..:|:|:                                   ::..|:.
 Worm   689 TMETSNSM-----SIRELNEQMS-----------------------------------SDPDLSA 713

  Fly  1446 LALDPNNSPAWERGGSHPQPAHHHPHHHP--LQHPHAGAGDPRQTQEQLQLQEAVQQKQSRKMPL 1508
            :.||...|..:|                |  |:.|:|         |:..:.||:.:.....:..
 Worm   714 VHLDVLTSNGFE----------------PFVLEFPNA---------EKRSVFEAMFKDAKATLAK 753

  Fly  1509 FVKAMPVYKSQHQTEVRCGCYYSIANDTK---QSGNAR----RRHKQLNYLWMCSSDGTSSHITV 1566
            .:.|.|          .|.....||:.|:   |...|.    :|......||:|:||..|..:.|
 Worm   754 NLLAAP----------SCSLKTIIAHQTRPGLQLCTATVVPGKRVDSTPSLWVCASDKFSGQVAV 808

  Fly  1567 LAQHPQQAGNLREAGAFDLFETQVSALEFV------------------------------KGLDQ 1601
            :|   ...|.:.......:....|:|:..|                              .|.|.
 Worm   809 MA---LDTGEITIESCSAIGNAAVTAMCTVPPPMKLRKRKIKSQKSLEHLLNETIMDINSSGSDT 870

  Fly  1602 LKSRDEPASLLGD-LVWLGTDSRKILIYSARNPEQEEQLGSYS------VPGAVQRILYHFDAVY 1659
            ..|.||..|..|. .||:|.|..::.:.::     .|::.|.:      :..::..|......|.
 Worm   871 ESSSDEGTSTAGQTTVWIGNDDGEVFVVNS-----TERVRSRARDRLARLRNSITSICAANGNVL 930

  Fly  1660 VALSGAT---VLIFRRGNDGVWQLRDPQTIRLGDT-DLVVPSLLPINMCIYASCGNRVYVMNALN 1720
            ||.|.:.   :|:||..:||.|.|.:|||:  |.. ...:.|:..|...:..:.||.::......
 Worm   931 VATSYSNQVQLLLFRPASDGSWDLENPQTV--GHVCQAPITSMQLIGRRVIIASGNWLHAYFVDT 993

  Fly  1721 GEIQRSFEVQHGATQQVNLMAHSGIGLWISLKNSTMLCLYHTETFKHLQDINIASSVLRHDGKKE 1785
            |:.|...|:. .::..:.||..:|..:::..:.||.:.:........:...|:.|.|......:|
 Worm   994 GKFQPPVEIL-PSSDVITLMYVTGQNVFLCGRKSTEVFVVDVFNLSIINHFNVVSFVRSQLSGRE 1057

  Fly  1786 QPLNN---SSVYVTALMACKGLLWVGTNVGIAVTI--------PLPRLEGVPIISGGINMSCHAH 1839
            ..|..   ..:.::.|...:..||:||:.|..::.        |.|.|....|          .|
 Worm  1058 HILREHKMGCLRISCLTVARSHLWIGTSAGCVLSTSVQSARSQPTPDLRVCEI----------GH 1112

  Fly  1840 FGPITFLLPLIPKVYPAYKPPTVGAAPLVPSMGDDLQLPAIDADPKI-----QELDDGAVVLRRD 1899
            .||...|||:        ..|:....|........|.:||..:...:     :.||||.
 Worm  1113 SGPCRILLPV--------HTPSHSNHPSRKQKRSSLNVPAQQSSQLMLVSCGEGLDDGT------ 1163

  Fly  1900 LAKEEMSSSNPGADS 1914
                  ::.:|..|:
 Worm  1164 ------ATQDPSTDA 1172

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43658	NP_001259643.1	RhoGEF	984..1153	CDD:279015	47/172 (27%)
osg-1	NP_498172.3	RhoGEF	361..543	CDD:214619	50/184 (27%)
		PH-like	524..>612	CDD:302622	26/110 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3522
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D43489at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5001
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850