DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43658 and arhgef10

DIOPT Version :9

Sequence 1:	NP_001259643.1	Gene:	CG43658 / 32729	FlyBaseID:	FBgn0263706	Length:	2263	Species:	Drosophila melanogaster
Sequence 2:	XP_002935203.3	Gene:	arhgef10 / 100490713	XenbaseID:	XB-GENE-877296	Length:	1376	Species:	Xenopus tropicalis

Alignment Length:	1088	Identity:	329/1088 - (30%)
Similarity:	518/1088 - (47%)	Gaps:	203/1088 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   930 EDDEATANRF-DVDLMMTPGSRANGTARTAHNRLIVPMLPPAPAGLSQQQLKRRHIVAAIVHSEN 993
            ||||  .|.| |||.|              |   |..::.|.|.||||||:.||:|:.:||.||.
Frog   392 EDDE--LNLFIDVDCM--------------H---IEAIMSPMPEGLSQQQVVRRYILGSIVESEK 437

  Fly   994 SYVATLQRLVNDYKKPLEECSPPVLNPVKIATLFHCLPDILHSHKLFRISLAECVRNWDRDEKIG 1058
            :||.:|:|::..|:|||.|..|.:|:..|:..:|:.:.:||..|.||:|:||..|..||..|.||
Frog   438 NYVDSLKRILEQYEKPLWETEPRLLSERKLKIVFYRIKEILQCHSLFQIALASRVAEWDTAEMIG 502

  Fly  1059 DCFVSAFGKPQLLEIYSGFINNFSAAMELAKMEEKRKSALADFFKVKQISAHDRLSFFGLMVKPV 1123
            |.||::|.|..:|:.||.::||||.|:.:.:.....|.:..:|.|..|.|:.||::.:|||:||:
Frog   503 DVFVASFSKSMVLDAYSEYVNNFSTAVGVLRKACATKPSFLEFLKQCQESSPDRITLYGLMMKPI 567

  Fly  1124 QRFPQFILFLQDLLKYTPQGHHDRMSLQLALSQLELLAELLNESKREAEQYQAFKEMLGHISGTF 1188
            ||||||||.|||:||.|.:||.||:.||:||::||.||:.|||.||:|:|....|:    |:...
Frog   568 QRFPQFILLLQDMLKNTNKGHPDRLPLQMALTELETLADKLNERKRDADQRCEIKQ----IAKAM 628

  Fly  1189 NARSLS--LSSVSVSDSAGGHRPRYLLREDNVTHMEFNQAGFIVKCKQRRLLLLNDKVICVSVAP 1251
            |.|.|:  ||:.|          |||:|.|::....||:.|.|:|.|||||.:|||.::|.:...
Frog   629 NERYLNKLLSNGS----------RYLVRSDDMVETVFNERGEIIKTKQRRLFMLNDVLMCATANA 683

  Fly  1252 KQSHDFGA----TEKLTFKWMFPVNDVEIVDNSTSATLSRILTAGLNRGGSLKSNGSSGANGSPY 1312
            :.|.:..:    .:|...||..|::..|:::                       .|.|...|...
Frog   684 RSSVEGSSAVTTNQKYLLKWSVPLSHAEVIE-----------------------YGESEDQGDQT 725

  Fly  1313 ANSTLPGHGGGVSGFSGFGDPH-------SSPAAQLTNGADNLCSEMSTLMYDYEVISRIQDLVS 1370
            ..|:|                |       ||...:|..|...|.:::..|::|.:|:::|..||.
Frog   726 LYSSL----------------HVAEKVVVSSKPNKLYMGPGQLYNDLQNLLHDLDVVNQISQLVG 774

  Fly  1371 SLKGSYKELNANTTRNVLNLIQGSIQRKDEEMAWVDSC--CLQLIGRH-KSGKEETFT--FQTQT 1430
            .|||:|:.||....::....:|..|.:|:.|:...|.|  .|||.|:. |||:...||  |.|.:
Frog   775 QLKGNYQNLNHAVAQDWSVGLQKLILKKENEIRAADRCRIQLQLPGKQDKSGRPTYFTAVFNTFS 839

  Fly  1431 PAVKKEWITELRLAQLALDPNNSPAWERGGSHPQPAHHHPHHHPLQHPHAGAGDPRQTQEQLQLQ 1495
            ||.|:.|::.|::|:|||...|:..|                                   ..|:
Frog   840 PAAKQSWLSNLQMAKLALGEENNTGW-----------------------------------FCLE 869

  Fly  1496 EAVQQKQSRKMPLFVKAMPVYKS-QHQTEVRCGC-----YYSIANDTKQSGNARRRHKQLNYLWM 1554
            :...|.:..|.||.||.:||..| |.:.::.|..     |.|..||.    :....|.  .:||:
Frog   870 DEGHQVKKEKHPLLVKHLPVVMSKQQEFKIECAVYNPEPYLSSENDP----DTLSMHH--GFLWI 928

  Fly  1555 CSSDGTSSHITVLAQHPQQAGNLREAGAFDLFETQVSALEFV------KGLDQLKSRDEPASLLG 1613
            .|.......|:||:.|.:....|.   .|:: |:::..:.::      |.|......:..:|.:.
Frog   929 GSCTNQMGQISVLSLHNRSPKVLE---CFNV-ESRILCMVYIPEEAKQKQLSDAPDLENGSSRVP 989

  Fly  1614 DL--VWLGTDSRKILIYSARNPEQEEQLGSYSVP--GAVQRILYHFDAVYVALSGATVLIFRRGN 1674
            |:  :.||.:...|.:|.:....::.:|..:..|  ..|..:......:|..|....:..:.:..
Frog   990 DVPTICLGMEEGSICVYKSSQGSKKVRLQHFFTPEKSTVMSLASISQCLYAGLVNGNLATYTKAE 1054

  Fly  1675 DGVWQLRDPQTIRLGDTDLVVPSLLPINMCIYASCGNRVYVMNALNGEIQRSFEVQHGATQQVNL 1739
            ||.|....|:.|:||  .|.|.|||.:...|:|:.|.:::::...:..|:..||........::.
Frog  1055 DGNWNTDQPKLIKLG--VLPVRSLLIMERTIWAASGEQIFIIGQDSNAIEHQFEAHSEEGMVISH 1117

  Fly  1740 MAHSGIGLWISLKNSTMLCLYHTETFKHLQDINIASSVLRHDGKKEQPLNN-----SSVYVTALM 1799
            ||.:|:|:||:....:.|.|:|||||:||||||||:           |::|     ..|.||:|:
Frog  1118 MAVAGVGIWIAFTTGSTLRLFHTETFEHLQDINIAT-----------PIHNMLPGQHRVSVTSLL 1171

  Fly  1800 ACKGLLWVGTNVGIAVTIPLPRLEGVPIISGGINMSCHAHFGPITFLL--PLIPKVYPAYKPPTV 1862
            .|.|||.||||:|:.|::|:|||:|:|.::|...:|.|||..|:.||:  ..|.|.|..
Frog  1172 VCHGLLMVGTNLGVIVSLPVPRLQGIPKVTGRGMVSYHAHHSPVKFLVKATAINKKYRR------ 1230

  Fly  1863 GAAPLVPSMGDDLQLPAIDADPK----IQELD-----------DGAVVLRRDLA----KEEMSSS 1908
                 .||....:....:..:..    :|:.|           |.||.|...:.    |.::|||
Frog  1231 -----TPSRCSQISHSELKNEDSHCTGVQQNDEAAASATNNNNDSAVWLGGSMGSIAQKSDLSSS 1290

  Fly  1909 NPGADSTASSPRSSKLDKQNSLDQSFTAKIRASLANSPAFHRKRFRDD 1956
            : |:.:.:....|....|::.............|.||.....||.:.|
Frog  1291 S-GSLTLSHGSNSCDAGKEDCTLSDLLGDPSMPLPNSKQQKAKRLKAD 1337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43658	NP_001259643.1	RhoGEF	984..1153	CDD:279015	77/168 (46%)
arhgef10	XP_002935203.3	RhoGEF	425..609	CDD:238091	85/183 (46%)
		PH_19	632..781	CDD:408827	49/197 (25%)
		WD40_2	889..1374	CDD:408826	125/484 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	239	1.000	Domainoid score	I2240
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D43489at33208
OrthoFinder	1	1.000	-	-		FOG0002580
OrthoInspector	1	1.000	-	-		otm48551
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2754
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.010