Protein Alignment CG43658 and arhgef10l

DIOPT Version :10

• Sequence 1: NP_001259643.1
• Gene: CG43658 / 32729
• FlyBaseID: FBgn0263706
• Length: 2263
• Species: Drosophila melanogaster
• Sequence 2: XP_031760704.1
• Gene: arhgef10l / 100158460
• XenbaseID: XB-GENE-996306
• Length: 1354
• Species: Xenopus tropicalis
• Alignment Length: 1439
• Identity: 395/1439 - (27%)
• Similarity: 609/1439 - (42%)
• Gaps: 346/1439 - (24%)

  Fly   724 RERDKNDDLGEE-EVLTE-EEQTSSSVSSLSAGNQRNSQLRSTFNKAKQHLSFDKWRTAATGSAT 786
            ::.|.:||.||. :..:| ||:.|.::.....      |||::      .:|.::...|.||..|
 Frog    78 QQEDDDDDQGEAFDFDSEGEEEDSGTIPKAEV------QLRTS------SISIERPPLAHTGEGT 130

  Fly   787 GSASGPGSSATDSNNAASNMIMRRASACTMPSSGGGGGAGVGSSQREEATTPGESPGGRLSRWFS 851
                   .:..:...||:.:.:.|:      ||....|..||..:.|..|.       .|.| .|
 Frog   131 -------ENLQNKTEAAAPVSLSRS------SSSVSNGDPVGRKKLEIYTC-------SLKR-SS 174

  Fly   852 IRRGSSHQYDVGGRDGRHSTASSFDTP---DSGSGNSPKN----GSNAVAGTGGAGSQGVAL--- 906
            ::|.||.:...|.| |....|...|.|   ::..|..|..    |::.|......| .|..|
 Frog   175 VKRDSSSEKVCGPR-GTQDGAIYEDVPCEQENQDGKEPARTPTLGASTVTPCASVG-LGYHLIYE 237

  Fly   907 ---DAASPQKLANLG-ASKMMPGVPESEDDEATANRFDV-------------------------- 941
               ...|.:.|.:.| :|.......|..::|....|..:
 Frog   238 NVHHEGSERDLEDTGWSSSEFESYSEDSEEEEEEERRKIKPAKPFVAFQPKLSPDLSRLKERYSR 302

  Fly   942 ---DLMMTPGSRANGTARTAH-----------------------NRLIV---------------- 964
               ||:...| |.:|.....|                       .|:.|
 Frog   303 TKRDLLALRG-RGSGAQELKHTYNWKMTQLMKAARSGTKDGLEKTRIAVMRKVTFLQRKETTGDS 366

  Fly   965 ---------------------PMLPPAPAGLSQQQLKRRHIVAAIVHSENSYVATLQRLVNDYKK 1008
                                 ..|.|.|.|||.||:.||||:|:||.||.|||.:|||::.||:.
 Frog   367 EEEESGFFEVIGLDLDLKPPPSELGPMPEGLSAQQVLRRHILASIVQSERSYVESLQRVLQDYRN 431

  Fly  1009 PLEECSPPVLNPVKIATLFHCLPDILHSHKLFRISLAECVRNWDRDEKIGDCFVSAFGKPQLLEI 1073
            ||.:..|.:|:..|...:|..:.:|||.|.:|:|:|:..|..||..||:||.||::|.|..:|::
 Frog   432 PLMDMEPKLLSTRKCQMVFSRVKEILHCHSVFQIALSSRVAEWDVSEKVGDLFVASFSKSIVLDV 496

  Fly  1074 YSGFINNFSAAMELAKMEEKRKSALADFFKVKQISAHDRLSFFGLMVKPVQRFPQFILFLQDLLK 1138
            ||.::|||:.||.:.|.....|.|..||.:.||.::.||::.:||||||:||||||||.|||:||
 Frog   497 YSEYVNNFTNAMTVIKKACLTKPAFLDFLRKKQAASPDRVTLYGLMVKPIQRFPQFILLLQDMLK 561

  Fly  1139 YTPQGHHDRMSLQLALSQLELLAELLNESKREAEQYQAFKEMLGHISGTFNARSLSLSSVSVSDS 1203
            .||.||.||:||||||::||.|||.|||.||.|:|....:::...||        ..||:..|.|
 Frog   562 NTPCGHPDRLSLQLALTELETLAEKLNEQKRVADQMAEIQQLCKSIS--------DRSSLYKSLS 618

  Fly  1204 AGGHRPRYLLREDNVTHMEFNQAGFIVKCKQRRLLLLNDKVICVSVAPKQSHDFGATEKL----T 1264
            :|.|:   ||..:.:|.|.:...|.::|.|:|||.|:||.::|.::..|...|.|....|    .
 Frog   619 SGQHQ---LLLCETLTEMVYGDKGQLLKSKERRLFLMNDVLVCANINFKGQPDIGNLVPLGPRYV 680

  Fly  1265 FKWMFPVNDVEIVDNSTSATLSRILTAGLNRGGSLKSNGSSGANGSPYANSTLPGHGGGVSGFSG 1329
            .||..|              |::|..|.|            |..|:.:....       .:|..|
 Frog   681 LKWNTP--------------LAQIYVAEL------------GQEGNAFEKDL-------AAGQQG 712

  Fly  1330 FGDPHSSPAAQLTN----GADNLCSEMSTLMYDYEVISRIQDLVSSLKGSYKELNANTTRNVLNL 1390
            .|..||. ::||.|    |:..|..|:..:..|.||:.:|..|:|:|.|:|:.||....::....
 Frog   713 VGRKHSF-SSQLQNKVSLGSPRLFQELQDVKRDLEVVEQITQLISTLHGTYQNLNMTVAQDWCLG 776

  Fly  1391 IQGSIQRKDEEMAWVDSCCLQL-IGR--HKSGKEETF--TFQTQTPAVKKEWITELRLAQLALDP 1450
            :|..::.|:||:...:.|.||| :.|  .|||:..:|  .|.|..|..|..|:..|.||::||..
 Frog   777 LQRLVRLKEEEIQSANKCHLQLQLPRKADKSGRPMSFMVVFITPNPLSKISWVNRLHLAKIALRE 841

  Fly  1451 NNSPAWERGGSHPQPAHHHPHHHPLQHPHAGAGDPRQTQEQLQLQEAVQQKQSRKMPLFVKAMPV 1515
            .|.|.|                                   |..:|..:.|.....|..|..:|.
 Frog   842 ENQPGW-----------------------------------LCPEEEKKVKAPFWSPTLVCRLPA 871

  Fly  1516 YKSQHQTEVRCGCYYSIANDTKQSGNARRRHKQLNYLWMCSSD-GTSSHITVLAQHPQQAGNLRE 1579
            :.::.......|..::...::....::........|||:.... |.:.||.:.:.:......|:
 Frog   872 FSTKAADLQLGGAVHTPVQNSLLGFSSVSTSLPQGYLWVGGGQVGGAGHIQIFSLNHTSPRMLK- 935

  Fly  1580 AGAFDLFETQVSALEFV-----KGLDQLKSRDEPASLLGD---LVWLGTDSRKILIYSARNPEQE 1636
              ||.| .:.|..:|.|     :|.|:   |||..|..|.   .|.:|.....|::|.  |.:..
 Frog   936 --AFPL-PSCVLCVENVCPRAPEGNDE---RDEEESAAGSARPAVCVGLQDGSIMVYG--NVDTG 992

  Fly  1637 EQ-LGSYSVPGAVQ--RILYHFDAVYVA-LSGATVLIFRRGNDGVWQLRDPQTIRLGDTDLVVPS 1697
            .. |.:...|| ||  :.|.|..:...| |...:|.::.....|:|....|..:::||..  |.:
 Frog   993 TPCLMAVGSPG-VQPVKCLRHSPSFLCAGLQDGSVALYPATQGGLWDPGSPLVVKVGDGP--VQA 1054

  Fly  1698 LLPINMCIYASCGNRVYVMNALNGEIQ-RSFEVQHGATQQVNLMAHSGIGLWISLKNSTMLCLYH 1761
            ||.|:.|::|||.|||.|:..  |.:: ::||........:..|..||.|:|::....:.:.|:|
 Frog  1055 LLVIDGCVWASCRNRVTVLEP--GTLKTQTFEAVQDEGISITHMVRSGGGVWMAFSGGSSIRLFH 1117

  Fly  1762 TETFKHLQDINIASSVLRHDGKKEQPLNNSSVYVTALMACKGLLWVGTNVGIAVTIPLPRLEGVP 1826
            |||.:.||:||||:..:...|:|       :..:|||:.|:|||||||::||.||:|:|:|||:|
 Frog  1118 TETLELLQEINIATRTMLLPGQK-------NPRITALLICQGLLWVGTDLGILVTLPVPKLEGIP 1175

  Fly  1827 IISGGINMSCHAHFGPITFLLPLIPKVYPAYKPPTVGAAPLVP-------SMGDDLQLPAIDADP 1884
            .|:|...:|.:.|.||:.||              |:..:.:.|       ..|:|:......|:|
 Frog  1176 KITGKGMVSLNGHCGPVQFL--------------TLACSSIAPDELRTDQGSGEDISQSDGPAEP 1226

  Fly  1885 KIQELDDGAVVLRRDLAKEEMS------------------------SSNPGADSTASSPRSSKLD 1925
            | ::..||.     ||..:...                        |:..|:.:.:.:|.:|:.|
 Frog  1227 K-EDTPDGP-----DLPSDNAPPSRLKGILLQYRLRGTSHLPGLHLSAREGSRTDSCTPATSEED 1285

  Fly  1926 KQNSLDQSFTAKIRASLANSP-AFHRKR-FRDDPNRMSKTLPRGLGAAAAGSGAGG--------A 1980
              .|:.:         :|:.| .:.|.| ...|.||...|     .......|||.        |
 Frog  1286 --GSIYE---------MADEPDVWCRSRPCSKDANRKEIT-----SVVIVSGGAGHRTFHPSPCA 1334

  Fly  1981 SAAGSGTAS 1989
            |..|..|.|
 Frog  1335 SQPGGDTDS 1343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43658	NP_001259643.1	RhoGEF	984..1153	CDD:459876	83/168 (49%)
		PH_19	1210..1376	CDD:465965	46/173 (27%)
		WD40_2	1551..>1846	CDD:465964	100/308 (32%)
arhgef10l	XP_031760704.1	RhoGEF	404..588	CDD:238091	94/183 (51%)
		PH_19	615..763	CDD:465965	50/184 (27%)
		WD40_2	871..1354	CDD:465964	136/530 (26%)