DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment p-cup and wa-cup

DIOPT Version :9

Sequence 1:	NP_573216.1	Gene:	p-cup / 32727	FlyBaseID:	FBgn0030840	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_649721.2	Gene:	wa-cup / 40892	FlyBaseID:	FBgn0037502	Length:	580	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	165/525 - (31%)
Similarity:	264/525 - (50%)	Gaps:	50/525 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KSLLLRSQ--QSLVRPDLALLDIQISKRAIETMFGHRRELSFNHSHTADIIAKKCEELFNANEFE 71
            ::|:.|||  :|:.....||.|   ..||.:.:...:..::     ..::..:.|:.|:.:|..|
  Fly    71 RALMRRSQLKRSMGLASEALKD---CSRAEDLLMSRKPPVT-----NPNVSLEVCDALYESNRLE 127

  Fly    72 NALTTLYTDGRPF-GGQFAHG----RFEMIKQRSLAVFEDTLGESLRPFMHQHRDVLEQINRRQK 131
            ::...|:...:.| .||  .|    |..::.:.    |.|||.:...      ..|...|||...
  Fly   128 DSKINLHCHLKRFSSGQ--RGPVLDRLNVLNEN----FHDTLSDDTT------MSVQRLINRMMA 180

  Fly   132 ELAAHVSRPLWKKLRDQQQCDVQSIIIKERPQLTLLEKARRRASESLYNHNYLGRSAVDIALLRQ 196
            .||   ..|  |.::|  .|||.||:..|...|:.||.|||:....:||..||.:..||:|.|:.
  Fly   181 SLA---KEP--KDIKD--TCDVVSIMENEETHLSPLEMARRKRHFKIYNQTYLNKCWVDVAFLKT 238

  Fly   197 LRSDRNFLDPLRLATTPPMRKLTRRQFTIVRRLMKMLQARNPLYNRRYVQQRHGPIADQERRRWQ 261
            ||.|.|.|......::..:.||....:...|.|.|.|..|:|:|...  ||::...|...:.|
  Fly   239 LRDDPNVLPKHCKKSSEYLGKLMASNYKAERTLTKTLHTRSPMYALH--QQKYPNEAFYNKHR-- 299

  Fly   262 EMHLFHAQYQTRRDCMRMLHEVHKRRREGDVEKLSDYVENIMSGFIEYKTHRTLPWKFEFINEVY 326
            |.:|:..||||||:..::|..:....|.|::.||:.::|.:|..::..||:|.:||||||.||||
  Fly   300 EENLYRIQYQTRRNMFKILRSIRLLIRVGELNKLTTFIEEVMGDYVTIKTNRVMPWKFEFTNEVY 364

  Fly   327 NILALAYCDKCAVPANVDFLQAQNRPI-LYLLRTEKLHDMSVQFGGPNIYVEIEKE---DERHSR 387
            |.|.||..::..:|:|:..||.:.|.: |:.|......||..........:.|.:.   |.:...
  Fly   365 NYLGLARINEYKIPSNMTVLQGKQRLLTLFRLPLSNSLDMKKSKTKRTSALNITRSATTDPKAEH 429

  Fly   388 ISQKLEQLENRLRHSRFAIERSYLLFEIARCHFQESRFDKCLVVARKAFNEARSCNCLIWRFNSI 452
            ..:::.:||||:|.:.:.|||:|||.|:|:.|...:.||....:||.|..||..|..:||.|.|:
  Fly   430 FKKQVVRLENRMRFAEYHIERAYLLHELAQEHLNCNSFDGACSMARMALEEAIKCKSVIWSFLSL 494

  Fly   453 FLGCQVHAVLNRFERLKESLAKASQLASELQAPKLVAYIAICINVNNYDLALQRI--------RQ 509
            .:.|:.||:|.:.||.||.||:|.:||.:::...|..:|.|||.||..::.::|:        ||
  Fly   495 MVICKAHAILGKIEREKEILAEAFELAKKMKNLDLCLFIDICIKVNAEEMEMKRMVTTDLTAKRQ 559

  Fly   510 SDGNK 514
            ..|:|
  Fly   560 KFGSK 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p-cup	NP_573216.1	None
wa-cup	NP_649721.2	TPR_11	39..99	CDD:290150	10/30 (33%)
		TPR repeat	39..64	CDD:276809
		TPR repeat	69..99	CDD:276809	10/30 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450496
Domainoid	1	1.000	152	1.000	Domainoid score	I8865
eggNOG	1	0.900	-	-		E1_2BEUU
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	152	1.000	Inparanoid score	I6773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0009964
OrthoInspector	1	1.000	-	-		otm50006
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR21391
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X7635
	9	8.890