Protein Alignment ENGase and ENGASE

DIOPT Version :10

• Sequence 1: NP_573215.1
• Gene: ENGase / 32726
• FlyBaseID: FBgn0030839
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_001382981.1
• Gene: ENGASE / 64772
• HGNCID: 24622
• Length: 809
• Species: Homo sapiens
• Alignment Length: 669
• Identity: 214/669 - (31%)
• Similarity: 297/669 - (44%)
• Gaps: 165/669 - (24%)

  Fly    32 TTEEEEEVVPVKKKRTEEGGGELKEVACEKETVQRE-----------KCQDKNTCR-----CSQL 80
            |.||:|:..|  :.|....|..:|:.  |:|||.||           :..||:|.:     .|.|
Human    30 TQEEQEDQEP--RPRRRRPGRSIKDE--EEETVFREVVSFSPDPLPVRYYDKDTTKPISFYLSSL 90

  Fly    81 EAEPIKDNRQLLEFRVRSRNIDWREYVLPLDTSVRTTPVYLDRQADFVGSTRRQVTEDNRRELLV 145
            |        :||.::.|          |....:|...|:          :.|:......|...|:
Human    91 E--------ELLAWKPR----------LEDGFNVALEPL----------ACRQPPLSSQRPRTLL 127

  Fly   146 CHDMMGNYLEDRHFHSSQKYDDYRFVHWSAVDYFCYFSHDYVTIPPCGWLNAAHRHGVPVVGTFI 210
            ||||||.||:||....|.....|.|.||..:|.|.||||..|||||.||.|.||||||.|:||||
Human   128 CHDMMGGYLDDRFIQGSVVQTPYAFYHWQCIDVFVYFSHHTVTIPPVGWTNTAHRHGVCVLGTFI 192

  Fly   211 VE--ATARLDE-FLASEE-SVESTVEALTRLCEHFGFEGWLVNVEVTVPLAKMPRLYRFVRQLTA 271
            .|  ...||.| |||.:| |.::..:.|.::.:.|.|:|||:|:|.::.||.:..:..|:|.||.
Human   193 TEWNEGGRLCEAFLAGDERSYQAVADRLVQITQFFRFDGWLINIENSLSLAAVGNMPPFLRYLTT 257

  Fly   272 ATESRVPHGRVFWYDSVTDDGQLRWQNELNSRNAKFFRHSHGTLINYAWDEGHLERSAQQVRREQ 336
            ....:||.|.|.|||||...|||:||:|||..|..||....|...||.|.|.||||...|....
Human   258 QLHRQVPGGLVLWYDSVVQSGQLKWQDELNQHNRVFFDSCDGFFTNYNWREEHLERMLGQAGER- 321

  Fly   337 SPRHRVFMGLDVFGRSR--KGGFHSWETMELIAKNGFSAGIFAPGWTFETLNRFGYNIKNPRGDD 399
              |..|::|:|||.|..  .|.|.:.:::|||.|:|||..:|||||.:|.|.:
Human   322 --RADVYVGVDVFARGNVVGGRFDTDKSLELIRKHGFSVALFAPGWVYECLEK------------ 372

  Fly   400 QVNASFLARNEAWWSRIWPTLATHPYTSLPFFTDFCVGSGRAKFERGWRILGED---SPFFNLSR 461
               ..|....:.:|.|:...|.||...||||.|.||:|.|..:.     ..|::   .|:::||.
Human   373 ---KDFFQNQDKFWGRLERYLPTHSICSLPFVTSFCLGMGARRV-----CYGQEEAVGPWYHLSA 429

  Fly   462 QSLQPSVPLGRNAM---------HH--FDEAYSGGCSLLVTNY------ERAFRLFVTDFELDRG 509
            |.:||.  .|.:.:         .|  .::|:.||.||||...      ..|.||    |.|...
Human   430 QEIQPL--FGEHRLGGDGRGWVRTHCCLEDAWHGGSSLLVRGVIPPEVGNVAVRL----FSLQAP 488

  Fly   510 V---LLLRYVFKIDGDAVGTMFDLLVRVTPLRRNDQDLHLFCGDYEGSIVAPQRCYLSPHESDLP 571
            |   :.|..|:|::|..     |:.|.          |.|..|| .||      |::
Human   489 VPPKIYLSMVYKLEGPT-----DVTVA----------LELTTGD-AGS------CHI-------- 523

  Fly   572 SGLFRLHHDSSS------------------------LAAGWQMRDYLVKFDGPVRVQDIGVKYQR 612
            .|:..|:.::||                        |:.||....|.|...|.: :.|:.|.:.|
Human   524 GGISVLNAETSSRHSLRPLRVPPTKLARWVGRCGRQLSGGWVQHCYEVSLRGCL-LLDLLVCFSR 587

  Fly   613 P----SESSTDAKLGFVYV 627
            |    .|.|...:||.:.|
Human   588 PPGSREEESFTCRLGEIQV 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ENGase	NP_573215.1	GH85_ENGase	144..476	CDD:119364	140/349 (40%)
ENGASE	NP_001382981.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..55		8/28 (29%)
		GH85_ENGase	126..444	CDD:119364	140/342 (41%)