DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5613 and engase

DIOPT Version :9

Sequence 1:	NP_573215.1	Gene:	CG5613 / 32726	FlyBaseID:	FBgn0030839	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_002932564.3	Gene:	engase / 100496567	XenbaseID:	XB-GENE-981873	Length:	720	Species:	Xenopus tropicalis

Alignment Length:	731	Identity:	197/731 - (26%)
Similarity:	303/731 - (41%)	Gaps:	185/731 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LESKELASISKVMEN--NDKASENDKITGITTEEEEEVVPVKKKRTEEGGGELKEVACEKETVQR 66
            ::.|.|....|.:..  |.|....:|:      :|:|.      |..|...:|..:...||.::.
Frog     1 MKRKRLVDEEKALSGSYNKKQRPPEKL------DEDEC------RDAESSAQLANMKVYKEVIRD 53

  Fly    67 E------KCQDKNTCRCSQLEAEPIKDNRQLLE--FRVRSRNID-WREYVLPLDTSVRTTPVYLD 122
            :      :..||||       :|||......||  |..:..|.| :...|:|:  :.|..|:
Frog    54 DIVPLSARHHDKNT-------SEPISFFLSNLEELFSWKPTNQDAFNVAVVPI--AKRHPPI--- 106

  Fly   123 RQADFVGSTRRQVTEDNRRELLVCHDMMGNYLEDRHFHSSQKYDDYRFVHWSAVDYFCYFSHDYV 187
                          |..|.:.||||||||.|.:||....|.....|.|.||..:|.|.||||...
Frog   107 --------------ESQRPKTLVCHDMMGGYQDDRFIQGSGAQQPYIFYHWQHIDIFVYFSHRMF 157

  Fly   188 TIPPCGWLNAAHRHGVPVVGTFIVE---ATARLDEFLASEESV-ESTVEALTRLCEHFGFEGWLV 248
            ::||..|.||||::||.|:||||.|   .....:.|||.|||. .:..:.:.||.|::.|:||.:
Frog   158 SLPPVCWTNAAHKNGVCVLGTFITEWEDGAKTCESFLAGEESTYHAVADQMVRLAEYYKFDGWFI 222

  Fly   249 NVEVTVPLAKMPRLYRFVRQLTAATESRVPHGRVFWYDSVTDDGQLRWQNELNSRNAKFFRHSHG 313
            |:|..:....:..|..|:..|......|:|.|.|.|||||..:|:|:||||||.:|..||....|
Frog   223 NIENVLSPVAVSNLPLFLSYLKEQLHERIPGGMVLWYDSVIHEGELKWQNELNDKNRNFFDSCDG 287

  Fly   314 TLINYAWDEGHLERSAQQVRREQSPRHRVFMGLDVFGRSR--KGGFHSWETMELIAKNGFSAGIF 376
            ...||.|.|.||:|..:..||..     :::|:|:|.|..  .|.|.:.:::::|.:.|.||.:|
Frog   288 IFTNYNWMEDHLQRMEEDPRRTD-----IYVGVDIFARGEVVGGKFDTVKSLQMIRQYGLSAALF 347

  Fly   377 APGWTFETLNRFGYNIKNPRGDDQVNASFLARNEAWWSRIWPTLATHPYTSLPFFTDFCVGSGRA 441
            ||||.:|.|.:               ..||...:.:||.:...|..|...:||..:.||:|.|:.
Frog   348 APGWVYECLEK---------------EQFLQNQDKFWSLLDSQLLIHSLCTLPICSSFCLGYGKK 397

  Fly   442 KFERGWRILGEDS-PFFNLSRQSLQP--------SVPLGR-NAMHHFDEAYSGGCSLLVTNYERA 496
            ::..|   .|||| |:||||.|.:||        :...|| .::...::|:.||.||::
Frog   398 RYSFG---EGEDSGPWFNLSAQEVQPIFSEIQPKAGEGGRVKSLICQEDAWHGGGSLVI------ 453

  Fly   497 FRLFVTDFELDRGV-----------------LLLRYVFKIDGDA-VGTMFDLLVRVTPLRRNDQD 543
                  :..|..|:                 |||..|:|::..: |....:|         :.||
Frog   454 ------EASLPSGIEGVTIRLFSLHVPAPPKLLLALVYKMENSSNVAVSLEL---------STQD 503

  Fly   544 LHLFCGDYEGSIVAPQRCYLSPHESDLPSGLFRLHHDSSSLAA--------------GWQMRDYL 594
                          .:.|.::..:|..|..:....|....||.              ||:.|.|:
Frog   504 --------------AKSCNVNKVDSITPLSVESTVHPLQPLAKPPLPVTDTQLNPKHGWEQRYYV 554

  Fly   595 VKFD---------------------------GPVRVQDIGVKYQRPSESSTDAKLGFVYVDGLTL 632
            |...                           |.:|:.|.......|:: .||..|.  :|..|..
Frog   555 VHLSDCYLNSLSMRFSQLTPKEQEETFTCRIGEIRILDFSHPPLLPAQ-PTDLSLS--HVRWLHN 616

  Fly   633 EDLKDTWTDIPVYSKH 648
            |:....:..:.::..|
Frog   617 EEANQLFVSLTLHWSH 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5613	NP_573215.1	GH85_ENGase	144..476	CDD:119364	128/347 (37%)
engase	XP_002932564.3	GH85_ENGase	114..427	CDD:119364	126/335 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	188	1.000	Domainoid score	I3245
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D479155at33208
OrthoFinder	1	1.000	-	-		FOG0005197
OrthoInspector	1	1.000	-	-		oto102561
Panther	1	1.100	-	-	LDO	PTHR13246
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3708
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.020