DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8611 and DDX18

DIOPT Version :9

Sequence 1:	NP_788922.1	Gene:	CG8611 / 32725	FlyBaseID:	FBgn0027602	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_006764.3	Gene:	DDX18 / 8886	HGNCID:	2741	Length:	670	Species:	Homo sapiens

Alignment Length:	747	Identity:	215/747 - (28%)
Similarity:	351/747 - (46%)	Gaps:	155/747 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 KPKITRAERLGKKQR----QGKPLTKLSEEQ---ITRALKSNKKPKNPNQLPTPGDLFRAQLEEE 194
            :.||.: ..|..:||    ||.....|||.|   ::.....::|.|...|.|....|...|
Human    10 RKKIEK-RNLKLRQRNLKFQGASNLTLSETQNGDVSEETMGSRKVKKSKQKPMNVGLSETQ---- 69

  Fly   195 RRQKRREEGGGDQEASADEEDAKN-------NSGGGSPRVKPSSAVKESKKSSDIEDSGESGEES 252
                   .||..|||..:.:..|:       .:|..:.:...|.:.|:.||...:.:..|...:.
Human    70 -------NGGMSQEAVGNIKVTKSPQKSTVLTNGEAAMQSSNSESKKKKKKKRKMVNDAEPDTKK 127

  Fly   253 ATSDEEPDESSAQSPGQEKEPKQTAKKPPKAEETSSTNRFRTKKIGLFDQSDVEALKQL-GQRAV 316
            |.: |...:|..:|....||.:...:||...|:.|..........|.|:.:...:|..| .:..:
Human   128 AKT-ENKGKSEEESAETTKETENNVEKPDNDEDESEVPSLPLGLTGAFEDTSFASLCNLVNENTL 191

  Fly   317 KPVKETIFTGSKISTLGLHPHAVKNLEDLLSIRELTSVQQKTIPEVLQGKDVLVRSQTGSGKTLA 381
            |.:||..||                        .:|.:|.|:|..:|:|:|:|..::||||||||
Human   192 KAIKEMGFT------------------------NMTEIQHKSIRPLLEGRDLLAAAKTGSGKTLA 232

  Fly   382 YALPLVELLQKQQPRIQRKDGVLALVIVPTRELVMQTYELIQKLVKPYTWIVPGSLLGGESRKSE 446
            :.:|.|||:.|.  |...::|...|::.|||||.|||:.::::|:..:.... |.::||.:|.:|
Human   233 FLIPAVELIVKL--RFMPRNGTGVLILSPTRELAMQTFGVLKELMTHHVHTY-GLIMGGSNRSAE 294

  Fly   447 KARLRKGINILIGTPGRLVDHLLHTASFKLTKLQFLILDEADRLLELGYERDVKQLVEAIDKQRA 511
            ..:|..||||::.|||||:||:.:|..|....||.|::|||||:|::|:|.::||:::.:..:|
Human   295 AQKLGNGINIIVATPGRLLDHMQNTPGFMYKNLQCLVIDEADRILDVGFEEELKQIIKLLPTRR- 358

  Fly   512 ECEDKELPQLQRMLLSATLTSQVQQLAGLTL-KNPLYIDNSDEAASAALKSKDGYQKETIEALLE 575
                      |.||.|||.|.:|:.||.::| |.|||:...|:.|:|.:
Human   359 ----------QTMLFSATQTRKVEDLARISLKKEPLYVGVDDDKANATV---------------- 397

  Fly   576 VDDGLGEYQEDVTGVLSIPENLQLSYVVVPPKLRLVALSSLLAKEVDASPKQFKAIVFMSTTEMV 640
              ||                 |:..|||.|.:.|.:.|.:.|.|.     ::.|.:||.|:...|
Human   398 --DG-----------------LEQGYVVCPSEKRFLLLFTFLKKN-----RKKKLMVFFSSCMSV 438

  Fly   641 NFHHDMLNEALTRRVLDEEDEQEKGDSDDDGDIPLLQGLRFFKLHGSMTQTERQGVFRGFRDCAS 705
            .:|:::||..                     |:|:|      .:||...|.:|...|..|.:..|
Human   439 KYHYELLNYI---------------------DLPVL------AIHGKQKQNKRTTTFFQFCNADS 476

  Fly   706 CVLLATDVVGRGIDVPDIKLVVQYTPPQTTADFVHRVGRTARA--GRKGRAVLFLTPSEAQFVRH 768
            ..||.|||..||:|:|::..:|||.||....:::||||||||.  || |.|:|.|.|.|..|:|:
Human   477 GTLLCTDVAARGLDIPEVDWIVQYDPPDDPKEYIHRVGRTARGLNGR-GHALLILRPEELGFLRY 540

  Fly   769 LEKKRIRIQQGDMYAYLQTLLPKDDEARTVQEAASNLQHKFQTLLEDDRELHDKSCKAFVSWMKF 833
            |::.::.:.:.| :::               ...|::|.:.:.|:|.:..||..:.:|:.|:::.
Human   541 LKQSKVPLSEFD-FSW---------------SKISDIQSQLEKLIEKNYFLHKSAQEAYKSYIRA 589

  Fly   834 YSTFPKELKPIFNVRIAHMGHFAKSFALKEAP 865
            |.:  ..||.||||...::...|.||..|..|
Human   590 YDS--HSLKQIFNVNNLNLPQVALSFGFKVPP 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8611	NP_788922.1	DUF2413	203..>285	CDD:287302	20/88 (23%)
		P-loop_NTPase	332..548	CDD:304359	80/216 (37%)
		DEXDc	348..554	CDD:214692	82/206 (40%)
		HELICc	601..757	CDD:238034	52/157 (33%)
		DUF4217	805..866	CDD:290667	19/61 (31%)
DDX18	NP_006764.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..169		32/149 (21%)
		DEADc	179..386	CDD:238167	87/244 (36%)
		Q motif	179..207		8/51 (16%)
		DEXDc	194..382	CDD:214692	81/225 (36%)
		DEAD box	333..336		2/2 (100%)
		HELICc	400..529	CDD:238034	53/161 (33%)
		DUF4217	561..619	CDD:290667	18/59 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920