DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8611 and DBP7

DIOPT Version :9

Sequence 1:	NP_788922.1	Gene:	CG8611 / 32725	FlyBaseID:	FBgn0027602	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_012949.1	Gene:	DBP7 / 853894	SGDID:	S000001732	Length:	742	Species:	Saccharomyces cerevisiae

Alignment Length:	782	Identity:	230/782 - (29%)
Similarity:	362/782 - (46%)	Gaps:	157/782 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 DQEASADEEDAKNNSGGGSPRVK-----PSSAVKESKKSSDIEDSG---ESGEESATSDEEPDES 262
            |...|:.::.||...|....|.:     ....|...:|::...|.|   ..||.|.....:  ||
Yeast    16 DTAGSSYKQAAKVTGGRWKDRRRMKMKLEGKTVSRKRKANTTGDEGIIPGRGENSIKKLHK--ES 78

  Fly   263 SAQSPGQEKEPKQTAKK------PPKAEETSS---TNRFRTKKI--GLFDQSDVEALKQLGQRAV 316
            |..|..|||...:.|..      |..::..||   :||..|..:  .:.|::          .|:
Yeast    79 SYSSEEQEKYKGRNAHNTQGRTLPADSQFVSSLFTSNREITTAVNTNIHDEN----------VAI 133

  Fly   317 KPVKETIFTGSKISTLGLHPHAVKNLEDLLSIRELTSVQQKTIPEVL--QGK-DVLVRSQTGSGK 378
            .|....: .|.:.::||:....|.:||..:.|::.||:|::.||:::  .|| |..:.:||||||
Yeast   134 NPSNAPL-KGDQFASLGVSSLLVSHLEQKMRIKKPTSIQKQAIPQIIGNAGKNDFFIHAQTGSGK 197

  Fly   379 TLAYALPLVELLQKQQPRIQRKDGVLALVIVPTRELVMQTYELIQKLVKPYTWIVPGSLLGGESR 443
            ||:|.||::..:......:.|..|..||||.|||||..|.|.:...||....::||..|:|||.:
Yeast   198 TLSYLLPIISTILNMDTHVDRTSGAFALVIAPTRELASQIYHVCSTLVSCCHYLVPCLLIGGERK 262

  Fly   444 KSEKARLRKGINILIGTPGRLVDHLLHTASFK---LTKLQFLILDEADRLLELGYERDVKQLVEA 505
            ||||||||||.|.:||||||::|||.:|...|   ...|::::|||.|:|:|||::..:.::::.
Yeast   263 KSEKARLRKGCNFIIGTPGRVLDHLQNTKVIKEQLSQSLRYIVLDEGDKLMELGFDETISEIIKI 327

  Fly   506 IDKQRAECED-KELP-QLQRMLLSATLTSQVQQLAGLTLKNPLYIDNSDEAASAALKSKDGYQKE 568
            :.......|. .:|| :|..||.|||||..|.:|..:.||:...|.|             |.:|:
Yeast   328 VHDIPINSEKFPKLPHKLVHMLCSATLTDGVNRLRNVALKDYKLISN-------------GTKKD 379

  Fly   569 TIEALLEVDDGLGEYQEDVTGVLSIPENLQLSYVVVPPKLRLVALSSLL---AKEVDASPKQFK- 629
            :                |:..|  .|:.|.....:||||||||.|::.|   .|:..||.:|.|
Yeast   380 S----------------DIVTV--APDQLLQRITIVPPKLRLVTLAATLNNITKDFIASGQQSKT 426

  Fly   630 --AIVFMSTTEMVNFHHDMLNEALTRRVLDEEDEQEKGDS----------------DDDGDIPLL 676
              .|||:|.::.|.||:|..:.:      |...:...|||                ..|.|:.:
Yeast   427 LRTIVFVSCSDSVEFHYDAFSGS------DGHHKNLTGDSVRLLTKGNTMFPCFSDSRDPDVVI- 484

  Fly   677 QGLRFFKLHGSMTQTERQGVFRGF-RDCAS-----CVLLATDVVGRGIDVPDIKLVVQYTPPQTT 735
                 :|||||::|..|....:.| ||..:     .::..|||..||:|:|.:..|::..||...
Yeast   485 -----YKLHGSLSQQMRTSTLQHFARDNEATKGKHLIMFCTDVASRGLDLPHVGSVIELDPPFAV 544

  Fly   736 ADFVHRVGRTARAGRKGRAVLFLTPSEAQ-FVRHLEK--------------------KRIRIQQG 779
            .|.:||||||||||.||.::|||.|.|.: ::.:::.                    |.:.:.:.
Yeast   545 EDHLHRVGRTARAGEKGESLLFLLPGEEEKYMDYIQPYHPMGWELLKFDKEILMPAFKDVNVNRN 609

  Fly   780 DMYAYLQTLLPKDDEARTVQEAASNLQHKFQT-----------LLEDDRELHDKSCKAFVSWMKF 833
            |.:.       :.||..:..:...:.::::.|           .:..|....:.:.|.|:|.::.
Yeast   610 DKFI-------RKDEKSSKNKDVGDKEYEWDTNATTWHLNIERRVVGDSAFKNLAVKGFISHVRA 667

  Fly   834 YSTFPKELKPIFNVRIAHMGHFAKSFALKEAP-------SKFAAKHAAPKAAPPTNRLTYTERDP 891
            |:|...:.|..|||:..|:||.||||.|:|.|       ||.......|......|::....|..
Yeast   668 YATHISQEKKFFNVKFLHLGHLAKSFGLRERPKAMGLQSSKDGNSEKKPTKENSKNKMFRMARMA 732

  Fly   892 EK 893
            ||
Yeast   733 EK 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8611	NP_788922.1	DUF2413	203..>285	CDD:287302	22/92 (24%)
		P-loop_NTPase	332..548	CDD:304359	92/223 (41%)
		DEXDc	348..554	CDD:214692	89/213 (42%)
		HELICc	601..757	CDD:238034	62/183 (34%)
		DUF4217	805..866	CDD:290667	21/78 (27%)
DBP7	NP_012949.1	SrmB	114..738	CDD:223587	206/682 (30%)
DBP7	NP_012949.1	DEADc_DDX31	154..373	CDD:350707	90/218 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341443
Domainoid	1	1.000	151	1.000	Domainoid score	I934
eggNOG	1	0.900	-	-		E2759_KOG0348
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6389
Inparanoid	1	1.050	273	1.000	Inparanoid score	I589
Isobase	1	0.950	-	0	Normalized mean entropy	S1901
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003502
OrthoInspector	1	1.000	-	-		oto99684
orthoMCL	1	0.900	-	-		OOG6_102676
Panther	1	1.100	-	-	LDO	PTHR24031
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4831
SonicParanoid	1	1.000	-	-		X2393
TreeFam	1	0.960	-	-
	15	14.730