DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8611 and Ddx55

DIOPT Version :9

Sequence 1:	NP_788922.1	Gene:	CG8611 / 32725	FlyBaseID:	FBgn0027602	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_080685.2	Gene:	Ddx55 / 67848	MGIID:	1915098	Length:	600	Species:	Mus musculus

Alignment Length:	678	Identity:	191/678 - (28%)
Similarity:	298/678 - (43%)	Gaps:	143/678 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   334 LHPHAVKNLEDLLSIRELTSVQQKTIPEVLQGKDVLVRSQTGSGKTLAYALPLVELLQKQQPRIQ 398
            |||..:..|.: |....:|.||..|||..::.|||...:.||||||||:.:|::|:|.:::.::
Mouse    16 LHPRVLGALRE-LGFPHMTPVQSATIPLFMKNKDVAAEAVTGSGKTLAFVIPILEILLRREEKL- 78

  Fly   399 RKDGVLALVIVPTRELVMQTYELIQKLVKPY------TWIVPGSLLGGESRKSEKARLRK-GINI 456
            :|:.|.|:||.|||||.:|..|::....|.:      .||      ||.:...:..|.:: |.||
Mouse    79 KKNQVGAIVITPTRELAIQIDEVLSHFTKHFPQFSQILWI------GGRNPGEDVERFKQHGGNI 137

  Fly   457 LIGTPGRLVDHL------LHTASFKLTKLQFLILDEADRLLELGYERDVKQLVEAIDKQRAECED 515
            ::.|||||.|..      |..||. :..|..|:||||||||::|:|..:..::|.:.|||
Mouse   138 IVATPGRLEDMFRRKAEGLDLASC-VKSLDVLVLDEADRLLDMGFEASINTILEFLPKQR----- 196

  Fly   516 KELPQLQRMLLSATLTSQVQQLAGLTLKNPLYIDNSDEAASAALKSKDGYQKETIEALLEVDDGL 580
                  :..|.|||.|.:|:.|....|:||:.|...::..:|:...|
Mouse   197 ------RTGLFSATQTQEVENLVRAGLRNPVRISVKEKGVAASSTQK------------------ 237

  Fly   581 GEYQEDVTGVLSIPENLQLSYVVVPPKLRLVALSSLLAKEVDASPKQFKAIVFMSTTEMVNFHHD 645
                        .|..|:..|::.....:...|...|     .|.:|.|.:||.||...|.::..
Mouse   238 ------------TPSRLENHYMICKADEKFNQLVHFL-----RSRQQEKHLVFFSTCACVEYYGK 285

  Fly   646 MLNEALTRRVLDEEDEQEKGDSDDDGDIPLLQGLRFFKLHGSMTQTERQGVFRGFRDCASCVLLA 710
            .| |||.::|                        :...:||.| :.:|..:|..||...|.:|:.
Mouse   286 AL-EALLKKV------------------------KILCIHGKM-KYKRNKIFMEFRKLQSGILVC 324

  Fly   711 TDVVGRGIDVPDIKLVVQYTPPQTTADFVHRVGRTARAGRKGRAVLFLTPSEAQFVRHLE-KKRI 774
            |||:.||||:|::..|:||.||...:.||||.|||||.|..|.|::||.|.|..::..|. .::.
Mouse   325 TDVMARGIDIPEVNWVLQYDPPSNASAFVHRCGRTARIGHGGSALVFLLPMEEAYINFLAINQKC 389

  Fly   775 RIQQGDMYAYLQTLLPKDDEARTVQEAASNLQHKFQTLLEDDRELHDKSCKAFVSWMKFYSTFPK 839
            .:|:..:......|||                 |.:.:...||.:.:|..|||||:::.|:  ..
Mouse   390 PLQEMSLQRNTIDLLP-----------------KLRAMALADRAVFEKGMKAFVSFVQAYA--KH 435

  Fly   840 ELKPIFNVRIAHMGHFAKSFALKEAP--SKFAAKHAAPKAAP---PTNRLTYTERDPEKIQAQK- 898
            |...||.::.......|:.|||...|  .:...|. .|...|   .|:.:.:.::..|| |.||
Mouse   436 ECSLIFRLKDLDFAGLARGFALLRMPRMPELRGKQ-FPDFVPVDIDTDTIPFKDKIREK-QRQKL 498

  Fly   899 -RAKRRFTTTVSGEVRQLQQRDVGAQKP--------GAPPPKGGFIGGGVGRSSFMKSLGKSRAL 954
             ..||:..:...|..:.::.:....||.        .|...|..  |..:......:.|..:|.|
Mouse   499 LEQKRKERSENEGRKKFIKNKAWSKQKAKKERKKKMNAKRKKDE--GSDIDDEDMEELLNDTRLL 561

  Fly   955 NM--------SEFDSGLPPEGAAKRRKQ 974
            ..        .||:.||..  :|||..|
Mouse   562 KKFKKGKITEEEFEKGLLT--SAKRTVQ 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8611	NP_788922.1	DUF2413	203..>285	CDD:287302
		P-loop_NTPase	332..548	CDD:304359	81/226 (36%)
		DEXDc	348..554	CDD:214692	77/218 (35%)
		HELICc	601..757	CDD:238034	50/155 (32%)
		DUF4217	805..866	CDD:290667	18/62 (29%)
Ddx55	NP_080685.2	DEADc	9..224	CDD:238167	81/227 (36%)
		Q motif	9..37		7/21 (33%)
		DEXDc	24..228	CDD:214692	79/223 (35%)
		DEAD box	171..174		2/2 (100%)
		Helicase_C	252..363	CDD:278689	46/141 (33%)
		DUF4217	403..462	CDD:290667	20/77 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	499..551		8/53 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920