DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8611 and DDX55

DIOPT Version :9

Sequence 1:	NP_788922.1	Gene:	CG8611 / 32725	FlyBaseID:	FBgn0027602	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	XP_016875199.1	Gene:	DDX55 / 57696	HGNCID:	20085	Length:	618	Species:	Homo sapiens

Alignment Length:	689	Identity:	192/689 - (27%)
Similarity:	298/689 - (43%)	Gaps:	159/689 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   334 LHPHAVKNLEDLLSIRELTSVQQKTIPEVLQGKDVLVRSQTGSGKTLAYALPLVELLQKQQPRIQ 398
            |||..:..|.: |....:|.||..|||..::.|||...:.||||||||:.:|::|:|.:::.::
Human    16 LHPQVLGALRE-LGFPYMTPVQSATIPLFMRNKDVAAEAVTGSGKTLAFVIPILEILLRREEKL- 78

  Fly   399 RKDGVLALVIVPTRELVMQTYELIQKLVKPY------TWIVPGSLLGGESRKSEKARLR-KGINI 456
            :|..|.|::|.|||||.:|..|::....|.:      .||      ||.:...:..|.: :|.||
Human    79 KKSQVGAIIITPTRELAIQIDEVLSHFTKHFPEFSQILWI------GGRNPGEDVERFKQQGGNI 137

  Fly   457 LIGTPGRLVDHL------LHTASFKLTKLQFLILDEADRLLELGYERDVKQLVEAIDKQRAECED 515
            ::.|||||.|..      |..||. :..|..|:||||||||::|:|..:..::|.:.|||
Human   138 IVATPGRLEDMFRRKAEGLDLASC-VRSLDVLVLDEADRLLDMGFEASINTILEFLPKQR----- 196

  Fly   516 KELPQLQRMLLSATLTSQVQQLAGLTLKNPLYIDNSDE--AASAALKSKDGYQKETIEALLEVDD 578
                  :..|.|||.|.:|:.|....|:||:.:...::  |||:|.|:
Human   197 ------RTGLFSATQTQEVENLVRAGLRNPVRVSVKEKGVAASSAQKT----------------- 238

  Fly   579 GLGEYQEDVTGVLSIPENLQLSYVVVPPKLRLVALSSLLAKEVDASPKQFKAIVFM--------- 634
                           |..|:..|:|.....:...|...|...     ||.|.:||.
Human   239 ---------------PSRLENYYMVCKADEKFNQLVHFLRNH-----KQEKHLVFFRYSSGLCGR 283

  Fly   635 ---------STTEMVNFHHDMLNEALTRRVLDEEDEQEKGDSDDDGDIPLLQGLRFFKLHGSMTQ 690
                     ||...|.::...|.                         .|::|::...:||.| :
Human   284 GIRDSARMCSTCACVEYYGKALE-------------------------VLVKGVKIMCIHGKM-K 322

  Fly   691 TERQGVFRGFRDCASCVLLATDVVGRGIDVPDIKLVVQYTPPQTTADFVHRVGRTARAGRKGRAV 755
            .:|..:|..||...|.:|:.|||:.||||:|::..|:||.||...:.||||.|||||.|..|.|:
Human   323 YKRNKIFMEFRKLQSGILVCTDVMARGIDIPEVNWVLQYDPPSNASAFVHRCGRTARIGHGGSAL 387

  Fly   756 LFLTPSEAQFVRHLEKKRIRIQQGDMYAYLQTLLPKDDEARTVQEAASNLQHKFQTLLEDDRELH 820
            :||.|.|..::..|     .|.|   ...||.:.|        |...::|..|.:::...||.:.
Human   388 VFLLPMEESYINFL-----AINQ---KCPLQEMKP--------QRNTADLLPKLKSMALADRAVF 436

  Fly   821 DKSCKAFVSWMKFYSTFPKELKPIFNVRIAHMGHFAKSFALKEAPS--KFAAKHAAPKAAP---P 880
            :|..|||||:::.|:  ..|...||.::.......|:.|||...|.  :...|. .|...|   .
Human   437 EKGMKAFVSYVQAYA--KHECNLIFRLKDLDFASLARGFALLRMPKMPELRGKQ-FPDFVPVDVN 498

  Fly   881 TNRLTYTERDPEKIQAQK--RAKRRFTTTVSGEVRQLQQRDVGAQKPGAPPPK----------GG 933
            |:.:.:.::..|| |.||  ..:||..|...|..:.::.:....||......|          |.
Human   499 TDTIPFKDKIREK-QRQKLLEQQRREKTENEGRRKFIKNKAWSKQKAKKEKKKKMNEKRKREEGS 562

  Fly   934 FIGGG-----VGRSSFMKSLGKSRALNMSEFDSGLPPEG 967
            .|...     :..:..:|.|.|.: :...||:.||...|
Human   563 DIEDEDMEELLNDTRLLKKLKKGK-ITEEEFEKGLLTTG 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8611	NP_788922.1	DUF2413	203..>285	CDD:287302
		P-loop_NTPase	332..548	CDD:304359	80/226 (35%)
		DEXDc	348..554	CDD:214692	75/220 (34%)
		HELICc	601..757	CDD:238034	49/173 (28%)
		DUF4217	805..866	CDD:290667	18/60 (30%)
DDX55	XP_016875199.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920