Protein Alignment CG8611 and DDX24

DIOPT Version :9

• Sequence 1: NP_788922.1
• Gene: CG8611 / 32725
• FlyBaseID: FBgn0027602
• Length: 975
• Species: Drosophila melanogaster
• Sequence 2: NP_065147.1
• Gene: DDX24 / 57062
• HGNCID: 13266
• Length: 859
• Species: Homo sapiens
• Alignment Length: 994
• Identity: 212/994 - (21%)
• Similarity: 345/994 - (34%)
• Gaps: 378/994 - (38%)

  Fly   135 KAKPKITRAERLGKKQRQG-KPLTKLSEEQITRALKSNKKPKNPNQL------------------ 180
            |::||   ....||.|.:| |.:.|..|.:|           :||..
Human     7 KSRPK---QSSCGKFQTKGIKVVGKWKEVKI-----------DPNMFADGQMDDLVCFEELTDYQ 57

  Fly   181 -----PTPGDLFRAQLEEERRQKRREEGGGDQEASADEEDAKNNSGGGSPRVKPSSAVKESKKSS 240
                 ..|..||..:..:.:.|...||        .:||:.|::|        |...:| .|||.
Human    58 LVSPAKNPSSLFSKEAPKRKAQAVSEE--------EEEEEGKSSS--------PKKKIK-LKKSK 105

  Fly   241 DIEDSGES---------------GEESATSDEEPDESSAQ-----SPGQEK-------EPKQ-TA 277
            ::...|.|               |::....|.|..|.:::     :|.::|       ||.| ||
Human   106 NVATEGTSTQKEFEVKDPELEAQGDDMVCDDPEAGEMTSENLVQTAPKKKKNKGKKGLEPSQSTA 170

  Fly   278 KKPPKAEETSSTNRFRTKKIGLFDQ-SDVEALKQLGQRAVKPVKETIFTGSKISTLGLHPHAVKN 341
            .|.||..:|....        :.|| :||.|.|.|                      ..|..|..
Human   171 AKVPKKAKTWIPE--------VHDQKADVSAWKDL----------------------FVPRPVLR 205

  Fly   342 LEDLLSIRELTSVQQKTIPEVLQGK-DVLVRSQTGSGKTLAYALPLV------------------ 387
            ....|.....|.:|..|:...::.| |:|..::||||||||:|:|::
Human   206 ALSFLGFSAPTPIQALTLAPAIRDKLDILGAAETGSGKTLAFAIPMIHAVLQWQKRNAAPPPSNT 270

  Fly   388 ----------------------------------------------------------------- 387
                                                                             
Human   271 EAPPGETRTEAGAETRSPGKAEAESDALPDDTVIESEALPSDIAAEARAKTGGTVSDQALLFGDD 335

  Fly   388 -----------------------ELLQKQQP--------------RIQRKDGVLALVIVPTRELV 415
                                   |.|.|:|.              :...|..:|.||:.|||||.
Human   336 DAGEGPSSLIREKPVPKQNENEEENLDKEQTGNLKQELDDKSATCKAYPKRPLLGLVLTPTRELA 400

  Fly   416 MQTYELIQKLVKPYTWIVPGSLLGGESRKSEKARLRKGINILIGTPGRLVD-------HLLHTAS 473
            :|..:.|..:.: :|.|....|:||.|.:.::..|.:...|::.|||||.:       ||.:
Human   401 VQVKQHIDAVAR-FTGIKTAILVGGMSTQKQQRMLNRRPEIVVATPGRLWELIKEKHYHLRN--- 461

  Fly   474 FKLTKLQFLILDEADRLLELGYERDVKQLVEAIDKQRAECEDKELPQLQRMLLSATLTSQVQQLA 538
              |.:|:.|::|||||::|.|:..::.||:|.::      :.:..|:.|.::.|||||...|..|
Human   462 --LRQLRCLVVDEADRMVEKGHFAELSQLLEMLN------DSQYNPKRQTLVFSATLTLVHQAPA 518

  Fly   539 GLTLKNPLYIDNSDEAASA-ALKSKDGYQ-----------KETIEALLEVDDGLGEYQEDVTGVL 591
            .:..|.  :....|:.|.. .|..|.|.:           :.|:|.|.|........::|
Human   519 RILHKK--HTKKMDKTAKLDLLMQKIGMRGKPKVIDLTRNEATVETLTETKIHCETDEKD----- 576

  Fly   592 SIPENLQLSYVVVPPKLRLVALSSLLAKEVDASPKQF--KAIVFMSTTEMVNFHHDMLNEALTRR 654
                 ..|.|.::                      |:  :::||.::...:.....:|      :
Human   577 -----FYLYYFLM----------------------QYPGRSLVFANSISCIKRLSGLL------K 608

  Fly   655 VLDEEDEQEKGDSDDDGDIPLLQGLRFFKLHGSMTQTERQGVFRGFRDCASCVLLATDVVGRGID 719
            |||              .:||       .||..|.|.:|......|.....||||||||..||:|
Human   609 VLD--------------IMPL-------TLHACMHQKQRLRNLEQFARLEDCVLLATDVAARGLD 652

  Fly   720 VPDIKLVVQYTPPQTTADFVHRVGRTARAGRKGRAVLFLTPSEA----QFVRHLE---------- 770
            :|.::.|:.|..|:|:..:|||.||||||..:|.:::.:.|.:.    :..:.|:
Human   653 IPKVQHVIHYQVPRTSEIYVHRSGRTARATNEGLSLMLIGPEDVINFKKIYKTLKKDEDIPLFPV 717

  Fly   771 --------KKRIRIQ---QGDMYAYLQTLLPKDDEARTVQEAASNLQHKFQTLLEDDRELHDKSC 824
                    |:|||:.   :...|...|..|...    .:::||:.|:.:    ||:|..   |..
Human   718 QTKYMDVVKERIRLARQIEKSEYRNFQACLHNS----WIEQAAAALEIE----LEEDMY---KGG 771

  Fly   825 KAFVS----WMKFYSTFPKELK-----PIF--NVRIAHMGHFAKSFALKEAPSKFAAKHAAPKAA 878
            ||...    ..|......|||:     |:|  :.:..:.....|...|..||||  ::.|....:
Human   772 KADQQEERRRQKQMKVLKKELRHLLSQPLFTESQKTKYPTQSGKPPLLVSAPSK--SESALSCLS 834

  Fly   879 PPTNRLTYTERDPEKIQAQ 897
            ....:.|...::|:..|.|
Human   835 KQKKKKTKKPKEPQPEQPQ 853

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8611	NP_788922.1	DUF2413	203..>285	CDD:287302	25/109 (23%)
		P-loop_NTPase	332..548	CDD:304359	72/343 (21%)
		DEXDc	348..554	CDD:214692	70/333 (21%)
		HELICc	601..757	CDD:238034	42/157 (27%)
		DUF4217	805..866	CDD:290667	16/71 (23%)
DDX24	NP_065147.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	61..170		26/125 (21%)
		SrmB	191..783	CDD:223587	147/697 (21%)
		Q motif	192..220		7/49 (14%)
		P-loop_NTPase	194..511	CDD:304359	69/350 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	262..300		0/37 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	326..376		4/49 (8%)
		DEAD box	471..474		2/2 (100%)
		Helicase_C	573..681	CDD:278689	41/166 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	799..859		13/57 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010