DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8611 and Ddx56

DIOPT Version :9

Sequence 1:	NP_788922.1	Gene:	CG8611 / 32725	FlyBaseID:	FBgn0027602	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_080814.1	Gene:	Ddx56 / 52513	MGIID:	1277172	Length:	546	Species:	Mus musculus

Alignment Length:	654	Identity:	160/654 - (24%)
Similarity:	269/654 - (41%)	Gaps:	176/654 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   332 LGLHPHAVKNLEDLLSIRELTSVQQKTIPEVLQGKDVLVRSQTGSGKTLAYALPLVE-LLQKQQP 395
            :||.|..::.:.||...|. |.:|:|.||..|:|||:|.|::||||||.|||:|::: ||.|:..
Mouse    12 MGLDPRLLQAVTDLGWSRP-TLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQSLLHKKAT 75

  Fly   396 RIQRKDGVLALVIVPTRELVMQTYELIQKLVKPYTWIV-PGSLLGGESRKSEKARLRKGINILIG 459
            ....:..|..||:|||:||..|...:||:|.......| ..::...|...|::|.|.:..::::|
Mouse    76 GPVMEQAVRGLVLVPTKELARQAQAMIQQLAAYCARDVRVANVSAAEDSASQRAVLMEKPDVVVG 140

  Fly   460 TPGRLVDHLLHTASFKLTKLQFLILDEADRLLELGYERDVKQLVEAIDKQRAECEDKELPQL-QR 523
            ||.|::.||..........|:.|::||||.|...|:|.::|.|:         |   .||:: |.
Mouse   141 TPSRVLSHLQQNTLKLRDSLELLVVDEADLLFSFGFEDELKSLL---------C---HLPRIYQA 193

  Fly   524 MLLSATLTSQVQQLAGLTLKNPLYIDNSDEAASAALKSKDGYQKETIEALLEVDDGLGEYQEDVT 588
            .|:|||....||.|..|.|.||:.:    :...:.|...|  |.:..:.:.|.::
Mouse   194 FLMSATFNEDVQTLKELVLHNPVTL----KLQESQLPGPD--QLQQFQVVCETEE---------- 242

  Fly   589 GVLSIPENLQLSYVVVPPKLRLVALSSLLAKEVDASPKQFKAIVFMSTTEMVNFHHDMLNEALTR 653
                  :...|.|.::  ||.|:...:||.  |:...:.::..:|:   |..:....:||
Mouse   243 ------DKFLLLYALL--KLSLIRGKALLF--VNTLERGYRLRLFL---EQFSIPSCVLN----- 289

  Fly   654 RVLDEEDEQEKGDSDDDGDIPLLQGLRFFKLHGSMTQTERQGVFRGFRDCASCVLLATDV----- 713
                             |::||..     :.|  :.....||::    ||    ::|||.
Mouse   290 -----------------GELPLRS-----RCH--IISQFNQGLY----DC----VIATDAEILGP 322

  Fly   714 ----------------------VGRGIDVPDIKLVVQYTPPQTTADFVHRVGRTARAGRKGRAVL 756
                                  |.||||...:..|:.:..|.|...:|||.||||||...|..:.
Mouse   323 QVKGKRRGRGSKGNKASDPESGVARGIDFHHVSAVLNFDLPPTAEAYVHRAGRTARANNPGIVLT 387

  Fly   757 FLTPSEAQFVRHLE-------------KKRIRIQQGDMYAY-----LQTLLPKDDEARTVQEAAS 803
            |:.|:|..|:..:|             ..:.::::.:.:.|     ::::..:......::|...
Mouse   388 FVLPAEQPFLGKIEDLLSGEGEAPILLPYQFQMEEIESFRYRCRDAMRSVTKQAIREARLKEIKE 452

  Fly   804 NLQH--KFQTLLEDD-REL----HDKSCKAFVSWMKFYSTFPKELKPIFNVRIAHMGHFAKSFAL 861
            .|.|  |.:|..||: |:|    ||            ....|..:||       |:||
Mouse   453 ELLHSEKLKTYFEDNPRDLQLLRHD------------LPLHPAVVKP-------HLGH------- 491

  Fly   862 KEAPSKFAAKHAAPKAAPPTNRLTYTERDPEKIQAQKRAKRRFTTTVSGEVRQLQQRDVGAQ-KP 925
                   ...:..|.|   ...|.:..:...|:...::||:   ......:|..:.|  |.: ||
Mouse   492 -------VPDYLVPAA---LRGLVHPRKKRRKVPFSRKAKK---VKAQNPLRDFKHR--GKKPKP 541

  Fly   926 GAPP 929
            .|.|
Mouse   542 AAKP 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8611	NP_788922.1	DUF2413	203..>285	CDD:287302
		P-loop_NTPase	332..548	CDD:304359	79/218 (36%)
		DEXDc	348..554	CDD:214692	74/208 (36%)
		HELICc	601..757	CDD:238034	40/182 (22%)
		DUF4217	805..866	CDD:290667	16/67 (24%)
Ddx56	NP_080814.1	Q motif	7..35		7/23 (30%)
		SrmB	9..544	CDD:223587	158/651 (24%)
		P-loop_NTPase	9..219	CDD:304359	79/223 (35%)
		DEAD box	166..169		2/2 (100%)
		HELICc	234..388	CDD:238034	42/213 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	324..344		0/19 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..546		10/43 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010