DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8611 and Dbp73D

DIOPT Version :9

Sequence 1:	NP_788922.1	Gene:	CG8611 / 32725	FlyBaseID:	FBgn0027602	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_476833.1	Gene:	Dbp73D / 39871	FlyBaseID:	FBgn0004556	Length:	687	Species:	Drosophila melanogaster

Alignment Length:	754	Identity:	182/754 - (24%)
Similarity:	304/754 - (40%)	Gaps:	204/754 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 REEGGGDQEASADEEDAKNNSGGGSPRVKPSSAVKE------SKKSSDIEDSGESGEESATSDEE 258
            :|:..|.|..:.::|..:......:.|.:...|::.      .|::||:::| ||.||..   ||
  Fly    14 KEQKDGAQGTNNEDEILQKLLKKAAKRKRKHEAIEVVETPILEKETSDVKES-ESKEEQV---EE 74

  Fly   259 PDESSAQSPGQEKEPKQTAKKPPKAEETSSTNRFRTKKIGLFDQSDVEALK---QLGQRAVKPVK 320
            |:           :|.:..:     ||...:|.|:.  :| .|.|..:..|   ||......|
  Fly    75 PE-----------KPLEVVQ-----EEDVPSNEFQV--LG-GDDSAAKKKKVQMQLPNWLAHP-- 118

  Fly   321 ETIFTGSKISTLGLHP--HAVKNLEDL----------LSIRELTSVQQKTIPEVLQG-------- 365
             ||..|..:......|  .|:..|:.|          :.|:.|..||::.||.:|:.
  Fly   119 -TIIEGGSLQPEEEVPASEAIDQLDYLEKYTCQALKQMKIKRLFPVQKQVIPWILEAHAKPPPFR 182

  Fly   366 -KDVLVRSQTGSGKTLAYALPLVELLQKQQPRIQRKD-GVLALVIVPTRELVMQTYELIQKLVKP 428
             :|:.|.:.||||||||:|:|:|:||.      ||.| .|.|||::|..||.:|.|.:|.:|...
  Fly   183 PRDICVSAPTGSGKTLAFAIPIVQLLS------QRVDCKVRALVVLPVAELALQVYRVISELCSK 241

  Fly   429 YTWIVPGSLLGGESRKSE---------KARLRKGINILIGTPGRLVDHLLHTASFKLTKLQFLIL 484
            ....|  .||..:.:..:         |.:.....:|::.|||||||||..|..|.|..|:||::
  Fly   242 TELEV--CLLSKQHKLEDEQEKLVEQYKGKYYSKADIVVTTPGRLVDHLHATKGFCLKSLKFLVI 304

  Fly   485 DEADRLLELGYERDVKQLVEAIDKQRAECEDKEL-----------------PQLQRMLLSATLTS 532
            |||||:::..::..:..|    |....|..|:.|                 .|..::|.||||:.
  Fly   305 DEADRIMDAVFQNWLYHL----DSHVKETTDQLLAGTQAPLCYAELQASFGKQPHKLLFSATLSQ 365

  Fly   533 QVQQLAGL----------TLKNPLYIDNSDEAASAALKSKDGYQKETIEALLEVDDGLGEYQEDV 587
            ..::|..|          .|..|:..|.::|.|..             |||.:....:|.|
  Fly   366 DPEKLQDLRLFQPRLFATVLTMPVLKDATEEGADT-------------EALTDPGQFVGRY---- 413

  Fly   588 TGVLSIPENLQLSYVVVPPKLRLVALSSLLAKEVDASPKQFKAIVFMSTTEM---VNFHHDMLNE 649
                :.|..|...|.|...:|:.:.:.:|:.|.     |..:.:.|.::::.   :.|...:|.:
  Fly   414 ----TTPAELTEQYCVTELRLKPLTVFALVEKY-----KWKRFLCFTNSSDQATRLTFVLKVLFQ 469

  Fly   650 ALTRRVLDEEDEQEKGDSDDDGDIPLLQGLRFFKLHGSMTQTERQGVFRGFRDCASCVLLATDVV 714
            ..:.:|.:                          |.|:::...|....|.|.......|:.:|.:
  Fly   470 KYSTKVSE--------------------------LSGNLSAKVRNERLRDFAAGKINGLICSDAL 508

  Fly   715 GRGIDVPDIKLVVQYTPPQTTADFVHRVGRTARAGRKGRAVLFLTPSEAQF-------------- 765
            .|||||.|:.:|:.|..|:....::|||||||||||||.||..||..:...
  Fly   509 ARGIDVADVDVVLSYETPRHITTYIHRVGRTARAGRKGTAVTVLTEQDMTLFKKILSDANKGLGE 573

  Fly   766 ---------VRH---------------LEKKRIRIQQGDMYAYLQTLLPKDDEARTVQEAA--SN 804
                     ::|               ::.|..::.:.:..|....:..|.:|..||:...  ..
  Fly   574 EIHVSPDIEIQHAVEYKEALAGLRSEKVKNKNQKMAEKNRVATKALIHKKQEETATVRPLTLMEK 638

  Fly   805 LQHKFQTLLEDDRELHD-KSCKAFVSWMKFYSTFPKELK 842
            ||.|...:::..::..: |:.|......|:.   |||.|
  Fly   639 LQIKANEIVQSSKKSSETKNSKTKADKTKYQ---PKETK 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8611	NP_788922.1	DUF2413	203..>285	CDD:287302	17/87 (20%)
		P-loop_NTPase	332..548	CDD:304359	80/273 (29%)
		DEXDc	348..554	CDD:214692	77/251 (31%)
		HELICc	601..757	CDD:238034	41/158 (26%)
		DUF4217	805..866	CDD:290667	10/39 (26%)
Dbp73D	NP_476833.1	PRK11192	149..629	CDD:236877	134/543 (25%)
		DEAD	162..370	CDD:278688	70/219 (32%)
		HELICc	418..551	CDD:238034	42/163 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451628
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24031
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950