DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8611 and CG10333

DIOPT Version :9

Sequence 1:	NP_788922.1	Gene:	CG8611 / 32725	FlyBaseID:	FBgn0027602	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_609888.2	Gene:	CG10333 / 35112	FlyBaseID:	FBgn0032690	Length:	822	Species:	Drosophila melanogaster

Alignment Length:	913	Identity:	207/913 - (22%)
Similarity:	355/913 - (38%)	Gaps:	295/913 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SARKNQQQSPALSVKKRAQKSQD----FDFQFNVDKPKVKAIVVRRRAPPSKVEPTNSSVPNTTK 74
            |..::::..||:...:..::.:|    .|.||:.:|.:      |:|...|:.:......|...:
  Fly    11 SRERHREDRPAVGNPRDRERERDRVRERDRQFDREKER------RQRRSRSREDRNRRRSPERQR 69

  Fly    75 SPTPSV------------------SSSKSAISTLSASPKANASNDDLMFNVSPTKPPVKSVLGDD 121
             |..:|                  :..|:.:.|..|.||....:|:...:....|  ||
  Fly    70 -PRDNVRERSRERGGGAGGGGGGGAEKKAKMDTGDAPPKPLIVDDEEQQDGKEAK--VK------ 125

  Fly   122 FMLNVTTKPVVAQKAKPKITRAERLGKKQRQGKPLTK---LSEEQITRALKSNKKPKNPNQLPTP 183
                           |..::..|.|.||:|:.:..:|   |::||  |||::.|:
  Fly   126 ---------------KEPLSLEELLDKKKREEEARSKPVFLTKEQ--RALEAIKR---------- 163

  Fly   184 GDLFRAQLEEERRQKRREEGGGDQEASADEEDAKNN----SGGGSPRV-----KPSSAVK-ESKK 238
                  :.||..||:...:...:|.|:|.:......    ||...|.:     ||....: ..:.
  Fly   164 ------RQEEVERQRAAHDAAREQMAAASKVSISMGTAMASGAPPPAIVAPPPKPDRRERGGGRD 222

  Fly   239 SSDIEDSGESGE----ESATSDEEPDESSA--------------------------QSPGQE--- 270
            ..|..|.||.|:    |..|..::..|..|                          ...|::
  Fly   223 RGDRIDRGERGDDKRAEDLTHKDKEKELEAIRERYLGIIKKKRRVRRLNDRKFVFDWDAGEDTSI 287

  Fly   271 -------------------------KEPKQTAKK-------PPKAEETSSTNRFRTKKI------ 297
                                     ||.|:|..|       ..:.|......:.|.||:
  Fly   288 DYNNLYKERHHVQFFGRGNVAGIDIKEQKRTQSKFYGDLLEKRRTEAEKEQEKVRLKKMKRKEDK 352

  Fly   298 ---------------------GLFDQSDVEALKQLGQRAVKPVKETIFTGSKISTLGLHPHAVKN 341
                                 .:|.:.....:|  |.|...|::....:|        .|..:.:
  Fly   353 QKWDDRHWSEKENDEMTERDWRIFREDYNVTIK--GGRIPNPIRSWNESG--------FPKEIID 407

  Fly   342 LEDLLSIRELTSVQQKTIPEVLQGKDVLVRSQTGSGKTLAYALPLVELLQKQQPRIQRKD----G 402
            :.|.:..:|.|.:|::.||..||.:|::..::||||||||:.:||:..:| ..|:|:|.:    |
  Fly   408 IIDKVGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTLAFLIPLLSWIQ-SLPKIERLEDVDQG 471

  Fly   403 VLALVIVPTRELVMQTYELIQKLVKPY---TWIVPGSLLGGESRKSEKARLRKGINILIGTPGRL 464
            ..|:::.|||||..|..|...|..:|.   |.:|    :||.||:.:..|||.|..|:|.|||||
  Fly   472 PYAIIMAPTRELAQQIEEETTKFGQPLGIRTVVV----VGGLSREEQGFRLRLGCEIVIATPGRL 532

  Fly   465 VDHLLHTASFKLTKLQFLILDEADRLLELGYERDVKQLVEAI-------DKQRAECEDKELPQL- 521
            :| :|......|.:..:::||||||::::|:|.||::::|.:       |.:.||.|.|.:...
  Fly   533 ID-VLENRYLVLNQCTYIVLDEADRMIDMGFEPDVQKILEYMPVTNLKPDTEEAEDETKLMENFY 596

  Fly   522 ------QRMLLSATLTSQVQQLAGLTLKNP--LYIDNSDEAASAALKSKDGYQKETIEALLEVDD 578
                  |.::.:||:...|::||...|:.|  :||.:.            |...|..|.::.:
  Fly   597 TKKKYRQTVMFTATMPPAVERLARTYLRRPATVYIGSV------------GKPTERTEQIVYM-- 647

  Fly   579 GLGEYQEDVTGVLSIPENLQLSYVVVPPKLRLVALSSLLAKEVDASPKQFKAIVFMSTTEMVNFH 643
             :||..                        :...|..:|::::|.     ..|:|::
  Fly   648 -MGEND------------------------KRKKLMEILSRKIDP-----PVIIFVN-------- 674

  Fly   644 HDMLNEALTRRVLDEEDEQEKGDSDDDGDIPLLQGLRFF-----KLHGSMTQTERQGVFRGFRDC 703
                              |:||     .|: |.:||...     .|||...|.:|:......:..
  Fly   675 ------------------QKKG-----ADV-LAKGLEKLGYNSCTLHGGKGQEQREYALAALKSG 715

  Fly   704 ASCVLLATDVVGRGIDVPDIKLVVQYTPPQTTADFVHRVGRTARAGRKGRAVLFLTPSEAQFVRH 768
            |..:|:||||.|||||:.|:.||:.|...:|..|:.||:|||.|||:.|.|:.|:|..::.....
  Fly   716 AKDILVATDVAGRGIDIKDVSLVINYDMAKTIEDYTHRIGRTGRAGKTGCAISFVTKDDSALFYD 780

  Fly   769 LEK 771
            |::
  Fly   781 LKQ 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8611	NP_788922.1	DUF2413	203..>285	CDD:287302	23/156 (15%)
		P-loop_NTPase	332..548	CDD:304359	79/238 (33%)
		DEXDc	348..554	CDD:214692	79/228 (35%)
		HELICc	601..757	CDD:238034	44/160 (28%)
		DUF4217	805..866	CDD:290667
CG10333	NP_609888.2	DEADc	396..629	CDD:238167	80/246 (33%)
		DEXDc	409..632	CDD:214692	79/228 (35%)
		Helicase_C	651..761	CDD:278689	40/170 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451631
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930