DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8611 and Dbp21E2

DIOPT Version :9

Sequence 1:	NP_788922.1	Gene:	CG8611 / 32725	FlyBaseID:	FBgn0027602	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_608544.1	Gene:	Dbp21E2 / 33254	FlyBaseID:	FBgn0086130	Length:	536	Species:	Drosophila melanogaster

Alignment Length:	549	Identity:	135/549 - (24%)
Similarity:	227/549 - (41%)	Gaps:	124/549 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   262 SSAQSPGQEKEPKQTAK-KPPKAEETSSTNRFRTKKIGLFDQSDVE----ALKQLG--------- 312
            ::|.:..:.|.||..:| |..|.|...|..|.:. .:..::|:|.:    :|...|
  Fly    21 TAAAAAVKTKPPKAKSKGKKQKGEPLISCRRSQF-DLTQYEQTDAKFGSLSLASKGWLHNKSKGD 84

  Fly   313 -------------QRAVKPVKETI-FTGSKISTLGLHPHAVKNLEDLLSIRELTSVQQKTIPEVL 363
                         |:.::.|.|.: .||.:|     ||..::||...|.|:.||.:|::.:|.|.
  Fly    85 FFILNASVRGEELQQEMQTVDEFLESTGMQI-----HPQLLENLRVELGIKLLTGIQKQGMPVVH 144

  Fly   364 QGKDVLVRSQTGSGKTLAYALPLVE-LLQKQQPRIQRKDGVLALVIVPTRELVMQTYELIQKLVK 427
            ..:..|:.::||.|||:.|.||:|: ||||:....::.:....|::.|.|||..|...:.:||.:
  Fly   145 GNEHCLIAAETGCGKTITYLLPIVDKLLQKEVVTERKLNTPRVLILTPGRELATQIAGVTEKLTQ 209

  Fly   428 PYTWIVPGSLLGGESRKSEKARLRKGINILIGTPGRLVDHLLHTASFKLTKLQFLILDEADRLLE 492
            . |.:...|||||.:::.......:.::||:.|.|.| ..|:.|..:::.:::.|:|||||.||:
  Fly   210 G-TNLKVQSLLGGNTKQLMMNPQFEEVDILVATLGAL-SKLVTTGIYRMEQVRHLVLDEADTLLD 272

  Fly   493 ------LGY--ERDVKQLVEAIDKQRAECEDKELPQLQRMLLSATLTSQVQQLAGLTLKNPLYID 549
                  |.|  .|....||:           ||....|.:|.|||:.:..:::    |...:.:|
  Fly   273 DTFTDKLSYFLRRFPFHLVQ-----------KEDAGTQMILASATMPTNTREI----LHKVIDVD 322

  Fly   550 NSDEAASAALKSKDGYQKETIEALLEVDDGLGEYQEDVTGVLSIPENLQLSYVVVPPKLRLVALS 614
            ...|..|..|.....:..:....|.:.|                               |...|.
  Fly   323 TIREVVSPHLHRLMSHVTQKFLRLSKAD-------------------------------RPATLL 356

  Fly   615 SLLAKEVDASPKQFKAIVFMSTTEMVNFHHDMLNEALTRRVLDEEDEQEKGDSDDDGDIPLLQGL 679
            ||:..::   .|:...|||.:.:...:|....||.:                           |:
  Fly   357 SLVKHDL---AKRRPLIVFSNKSTTSDFVSIFLNNS---------------------------GV 391

  Fly   680 RFFKLHGSMTQTERQGVFRGFRDCASCVLLATDVVGRGIDVPDIKLVVQYTPPQTTADFVHRVGR 744
            ....|:|.|....|.|.|..|::....||..|||..||:|....:.||.:..|...:|::||.||
  Fly   392 NCLNLNGDMLMKIRLGRFEQFQNGHCDVLSTTDVGSRGLDTTRARHVVNFDFPLHVSDYIHRCGR 456

  Fly   745 TARAGRKGRAV---LFLTPSEAQFVRHLE 770
            ..|.|...:|:   |..:..|...|:.:|
  Fly   457 IGRVGNMDKALVTNLISSRREIDVVQRIE 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8611	NP_788922.1	DUF2413	203..>285	CDD:287302	7/23 (30%)
		P-loop_NTPase	332..548	CDD:304359	67/224 (30%)
		DEXDc	348..554	CDD:214692	63/214 (29%)
		HELICc	601..757	CDD:238034	38/158 (24%)
		DUF4217	805..866	CDD:290667
Dbp21E2	NP_608544.1	P-loop_NTPase	113..314	CDD:304359	67/218 (31%)
		DEXDc	126..330	CDD:214692	65/220 (30%)
		HELICc	343..462	CDD:238034	38/179 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451615
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24031
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030