DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8611 and ddx31

DIOPT Version :9

Sequence 1:	NP_788922.1	Gene:	CG8611 / 32725	FlyBaseID:	FBgn0027602	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	XP_021327284.1	Gene:	ddx31 / 325248	ZFINID:	ZDB-GENE-030131-3973	Length:	739	Species:	Danio rerio

Alignment Length:	873	Identity:	292/873 - (33%)
Similarity:	446/873 - (51%)	Gaps:	167/873 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 DDFMLNVTTKPVVAQKAKPKITRAERLGKKQRQGKPLTKLSEEQITRALKSNKKPKNPNQLPTPG 184
            |..|||:::..|                               |..|  |:|:|..:.::
Zfish     4 DTLMLNISSGSV-------------------------------QFNR--KTNQKHLSSSE----- 30

  Fly   185 DLFRAQLEEERRQKRREEGGGDQEASADEEDAKNNSGGGSPRVKPSSAVKESKKSSDIEDSGESG 249
                 :..:::|..:|:.....||:|..::...|.:|....:.:.....:...:.|:..|:
Zfish    31 -----KWAQKKRVAKRKAAVEPQESSVSKQRKINQTGQQHAQKQTLQTPRSPSQRSNNRDT---- 86

  Fly   250 EESATSDEEPDESSAQSPGQEKEPKQTAKKPPKAEETSSTNRFRTKKIGLFDQSDVEALKQLGQR 314
            |||....|   .|.|:||   .:.|...||.|...|.......:|..:...:....:.|..
Zfish    87 EESPVQRE---NSEAKSP---SKVKTFPKKAPTEHEDHGRPFIKTSSLFRNNPEIPDVLSP---- 141

  Fly   315 AVKPVKETIFTGSKISTLGLHPHAVKNLEDLLSIRELTSVQQKTIPEVLQGKDVLVRSQTGSGKT 379
            ||..|||.:||.:....|.||||.|..|..:|::..:||||::|||.::.|||.:||||||||||
Zfish   142 AVNQVKEKVFTSNTFEELNLHPHLVATLHKVLNVSSMTSVQKQTIPVLMSGKDAVVRSQTGSGKT 206

  Fly   380 LAYALPLVELLQKQQPRIQRKDGVLALVIVPTRELVMQTYELIQKLVKPYTWIVPGSLLGGESRK 444
            |||.:|:|:.||..||:::|.||.||:||||||||.:|::::.|||::|:||||||.|:|||.:|
Zfish   207 LAYGIPMVQFLQAIQPKVKRSDGPLAVVIVPTRELALQSFQMFQKLLRPFTWIVPGVLMGGEKKK 271

  Fly   445 SEKARLRKGINILIGTPGRLVDHLLHTASFKLTKLQFLILDEADRLLELGYERDVKQLVEAIDKQ 509
            :||||||||||:||.||||||||:.:|.|...:.:::||||||||:|:||:|:|:..::.|::..
Zfish   272 AEKARLRKGINVLISTPGRLVDHIKNTLSIAFSAVRWLILDEADRILDLGFEKDLTVILNALNTA 336

  Fly   510 RAECEDKELPQLQRMLLSATLTSQVQQLAGLTLKNPLYIDNSDEAASAALKSKDGYQKETIEALL 574
            .        |..|.:|||||:|..:.:||.:::|:|:.:..|:.:            :||:||..
Zfish   337 G--------PYRQNVLLSATITEGLSRLASISMKDPVSVHVSEGS------------EETVEACP 381

  Fly   575 EVDDGLGEYQEDVTGVLSIPENLQLSYVVVPPKLRLVALSSLLAKEVDASPKQFKAIVFMSTTEM 639
            :.      ..:.::...::||.||...||||.||.||.|::.:..:.....:| |.::|:|:.|.
Zfish   382 QA------APQALSDSYAVPERLQQHVVVVPSKLHLVCLAAFILAKCKFEQRQ-KLVIFISSCEA 439

  Fly   640 VNFHHDMLNEALTRRVLDEEDEQEKGDSDDDGDIPLLQGLRFFKLHGSMTQTERQGVFRGFRDCA 704
            |.|   :||  |...||.|........|        ...|.|::|||:|.|.||..||:.|..|.
Zfish   440 VEF---LLN--LFTAVLCEIPSNTSSKS--------TSCLNFYRLHGNMRQEERTEVFQEFSQCK 491

  Fly   705 SCVLLATDVVGRGIDVPDIKLVVQYTPPQTTADFVHRVGRTARAGRKGRAVLFLTPSEAQFVRHL 769
            :.:||.|||..||:|:|.:..:|||.||.:.|::|||||||||.|.:|.::|||||||..||..|
Zfish   492 TGILLCTDVAARGLDLPQVTWIVQYNPPVSAAEYVHRVGRTARIGAQGSSLLFLTPSETAFVDVL 556

  Fly   770 EKKRIRIQQGDMYAYLQTLLPKD---------DEART-------VQEAASNLQHKFQTLLEDDRE 818
            ....|.:.:..|...|.||: ||         |..|:       |:|.|:.||..|:..:....|
Zfish   557 ANHNISLSEMKMVDILSTLM-KDERFKGRGKWDSKRSADAFEQEVRERATLLQTDFENYVHASNE 620

  Fly   819 LHDKSCKAFVSWMKFYSTFPKELKPIFNVRIAHMGHFAKSFALKEAPSKFAAKHAAPKAAPPTNR 883
            ....:..|...:::.|:|:|..||.||::|:.|:||.||||.|::||...|:..:       ||
Zfish   621 SLQTAKSALQCFLRAYTTYPSSLKHIFHIRMLHLGHAAKSFGLRDAPQGLASSIS-------TN- 677

  Fly   884 LTYTERDPEKIQAQKRAKRRFTTTVSGEVRQLQQRDVGAQKPGAPPPKGGFIGGGVGRSSFMKSL 948
                   |...:..|:||.:                      ...|||              |..
Zfish   678 -------PANSKHSKKAKDK----------------------AKSPPK--------------KLT 699

  Fly   949 GKSRALNM--SEFDSGLPPEGAAKRRKQ 974
            .|.|..|:  ||:|||:..:..||::::
Zfish   700 AKQRVSNLMRSEYDSGMDGQSKAKKKRK 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8611	NP_788922.1	DUF2413	203..>285	CDD:287302	19/81 (23%)
		P-loop_NTPase	332..548	CDD:304359	114/215 (53%)
		DEXDc	348..554	CDD:214692	107/205 (52%)
		HELICc	601..757	CDD:238034	62/155 (40%)
		DUF4217	805..866	CDD:290667	22/60 (37%)
ddx31	XP_021327284.1	SrmB	124..613	CDD:223587	219/533 (41%)
ddx31	XP_021327284.1	DUF4217	607..668	CDD:316476	22/60 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574194
Domainoid	1	1.000	213	1.000	Domainoid score	I2696
eggNOG	1	0.900	-	-		E2759_KOG0348
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6389
Inparanoid	1	1.050	433	1.000	Inparanoid score	I1674
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250484at33208
OrthoFinder	1	1.000	-	-		FOG0003502
OrthoInspector	1	1.000	-	-		otm24467
orthoMCL	1	0.900	-	-		OOG6_102676
Panther	1	1.100	-	-	LDO	PTHR24031
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2393
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.760